ID A0A3Q2HF75_HORSE Unreviewed; 467 AA.
AC A0A3Q2HF75;
DT 10-APR-2019, integrated into UniProtKB/TrEMBL.
DT 13-SEP-2023, sequence version 2.
DT 27-MAR-2024, entry version 21.
DE RecName: Full=CUGBP Elav-like family member 2 {ECO:0000256|ARBA:ARBA00040736};
DE AltName: Full=Bruno-like protein 3 {ECO:0000256|ARBA:ARBA00042183};
DE AltName: Full=CUG triplet repeat RNA-binding protein 2 {ECO:0000256|ARBA:ARBA00041683};
DE AltName: Full=CUG-BP- and ETR-3-like factor 2 {ECO:0000256|ARBA:ARBA00042930};
DE AltName: Full=RNA-binding protein BRUNOL-3 {ECO:0000256|ARBA:ARBA00042509};
GN Name=CELF2 {ECO:0000313|VGNC:VGNC:16387};
OS Equus caballus (Horse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Perissodactyla; Equidae; Equus.
OX NCBI_TaxID=9796 {ECO:0000313|Ensembl:ENSECAP00000033040.2, ECO:0000313|Proteomes:UP000002281};
RN [1] {ECO:0000313|Ensembl:ENSECAP00000033040.2, ECO:0000313|Proteomes:UP000002281}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Thoroughbred {ECO:0000313|Ensembl:ENSECAP00000033040.2,
RC ECO:0000313|Proteomes:UP000002281};
RX PubMed=19892987; DOI=10.1126/science.1178158;
RG Broad Institute Genome Sequencing Platform;
RG Broad Institute Whole Genome Assembly Team;
RA Wade C.M., Giulotto E., Sigurdsson S., Zoli M., Gnerre S., Imsland F.,
RA Lear T.L., Adelson D.L., Bailey E., Bellone R.R., Bloecker H., Distl O.,
RA Edgar R.C., Garber M., Leeb T., Mauceli E., MacLeod J.N., Penedo M.C.T.,
RA Raison J.M., Sharpe T., Vogel J., Andersson L., Antczak D.F., Biagi T.,
RA Binns M.M., Chowdhary B.P., Coleman S.J., Della Valle G., Fryc S.,
RA Guerin G., Hasegawa T., Hill E.W., Jurka J., Kiialainen A., Lindgren G.,
RA Liu J., Magnani E., Mickelson J.R., Murray J., Nergadze S.G., Onofrio R.,
RA Pedroni S., Piras M.F., Raudsepp T., Rocchi M., Roeed K.H., Ryder O.A.,
RA Searle S., Skow L., Swinburne J.E., Syvaenen A.C., Tozaki T., Valberg S.J.,
RA Vaudin M., White J.R., Zody M.C., Lander E.S., Lindblad-Toh K.;
RT "Genome sequence, comparative analysis, and population genetics of the
RT domestic horse.";
RL Science 326:865-867(2009).
RN [2] {ECO:0000313|Ensembl:ENSECAP00000033040.2}
RP IDENTIFICATION.
RC STRAIN=Thoroughbred {ECO:0000313|Ensembl:ENSECAP00000033040.2};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC -!- SIMILARITY: Belongs to the CELF/BRUNOL family.
CC {ECO:0000256|ARBA:ARBA00009621}.
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DR AlphaFoldDB; A0A3Q2HF75; -.
DR Ensembl; ENSECAT00000032896.2; ENSECAP00000033040.2; ENSECAG00000006649.4.
DR VGNC; VGNC:16387; CELF2.
DR GeneTree; ENSGT00940000155461; -.
DR Proteomes; UP000002281; Chromosome 29.
DR Bgee; ENSECAG00000006649; Expressed in blood and 23 other cell types or tissues.
DR ExpressionAtlas; A0A3Q2HF75; baseline.
DR GO; GO:1990904; C:ribonucleoprotein complex; IEA:InterPro.
DR GO; GO:0003723; F:RNA binding; IEA:UniProtKB-UniRule.
DR CDD; cd12631; RRM1_CELF1_2_Bruno; 1.
DR CDD; cd12634; RRM2_CELF1_2; 1.
DR Gene3D; 3.30.70.330; -; 3.
DR InterPro; IPR034196; CELF1/2_RRM1.
DR InterPro; IPR034198; CELF1/2_RRM2.
DR InterPro; IPR002343; Hud_Sxl_RNA.
DR InterPro; IPR012677; Nucleotide-bd_a/b_plait_sf.
DR InterPro; IPR035979; RBD_domain_sf.
DR InterPro; IPR000504; RRM_dom.
DR PANTHER; PTHR24012:SF699; CUGBP ELAV-LIKE FAMILY MEMBER 2; 1.
DR PANTHER; PTHR24012; RNA BINDING PROTEIN; 1.
DR Pfam; PF00076; RRM_1; 3.
DR PRINTS; PR00961; HUDSXLRNA.
DR SMART; SM00360; RRM; 3.
DR SUPFAM; SSF54928; RNA-binding domain, RBD; 2.
DR PROSITE; PS50102; RRM; 2.
PE 3: Inferred from homology;
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000002281};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW RNA-binding {ECO:0000256|ARBA:ARBA00022884, ECO:0000256|PROSITE-
KW ProRule:PRU00176}.
FT DOMAIN 47..130
FT /note="RRM"
FT /evidence="ECO:0000259|PROSITE:PS50102"
FT DOMAIN 139..219
FT /note="RRM"
FT /evidence="ECO:0000259|PROSITE:PS50102"
SQ SEQUENCE 467 AA; 49684 MW; 50FABBCB2928DAD5 CRC64;
MTSAFKLDFL PDMMVEGRLL VPDRINGTAN KMNGALDHSD QPDPDAIKMF VGQIPRSWSE
KELKELFEPY GAVYQINVLR DRSQNPPQSK GCCFVTFYTR KAALEAQNAL HNIKTLPGMH
HPIQMKPADS EKSNAVEDRK LFIGMVSKKC NENDIRVMFS PFGQIEECRI LRGPDGLSRG
CAFVTFSTRA MAQNAIKAMH QSQTMEGCSS PIVVKFADTQ KDKEQRRLQQ QLAQQMQQLN
TATWGNLTGL GGLTPQYLAL LQQATSSSNL GAFSGIQQMA GMNALQLQNL ATLAAAAAAA
QTSATTTNAN PLSTTSSALG ALTSPVAAST PNSTAGAAMN SLTSLGTLQG LAGATVGLNN
INALAGMAAL NGGLGATGLT NGTAGTMDAL TQAYSGIQQY AAAALPTLYS QSLLQQQSAA
GSQKEGFVSY DNPVSAQAAI QAMNGFQIGM KRLKVQLKRS KNDSKPY
//
