ID A0A3Q2HH79_HORSE Unreviewed; 697 AA.
AC A0A3Q2HH79;
DT 10-APR-2019, integrated into UniProtKB/TrEMBL.
DT 13-SEP-2023, sequence version 2.
DT 27-MAR-2024, entry version 18.
DE SubName: Full=Mitogen-activated protein kinase 8 interacting protein 1 {ECO:0000313|Ensembl:ENSECAP00000033973.2};
GN Name=MAPK8IP1 {ECO:0000313|Ensembl:ENSECAP00000033973.2,
GN ECO:0000313|VGNC:VGNC:59269};
OS Equus caballus (Horse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Perissodactyla; Equidae; Equus.
OX NCBI_TaxID=9796 {ECO:0000313|Ensembl:ENSECAP00000033973.2, ECO:0000313|Proteomes:UP000002281};
RN [1] {ECO:0000313|Ensembl:ENSECAP00000033973.2, ECO:0000313|Proteomes:UP000002281}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Thoroughbred {ECO:0000313|Ensembl:ENSECAP00000033973.2,
RC ECO:0000313|Proteomes:UP000002281};
RX PubMed=19892987; DOI=10.1126/science.1178158;
RG Broad Institute Genome Sequencing Platform;
RG Broad Institute Whole Genome Assembly Team;
RA Wade C.M., Giulotto E., Sigurdsson S., Zoli M., Gnerre S., Imsland F.,
RA Lear T.L., Adelson D.L., Bailey E., Bellone R.R., Bloecker H., Distl O.,
RA Edgar R.C., Garber M., Leeb T., Mauceli E., MacLeod J.N., Penedo M.C.T.,
RA Raison J.M., Sharpe T., Vogel J., Andersson L., Antczak D.F., Biagi T.,
RA Binns M.M., Chowdhary B.P., Coleman S.J., Della Valle G., Fryc S.,
RA Guerin G., Hasegawa T., Hill E.W., Jurka J., Kiialainen A., Lindgren G.,
RA Liu J., Magnani E., Mickelson J.R., Murray J., Nergadze S.G., Onofrio R.,
RA Pedroni S., Piras M.F., Raudsepp T., Rocchi M., Roeed K.H., Ryder O.A.,
RA Searle S., Skow L., Swinburne J.E., Syvaenen A.C., Tozaki T., Valberg S.J.,
RA Vaudin M., White J.R., Zody M.C., Lander E.S., Lindblad-Toh K.;
RT "Genome sequence, comparative analysis, and population genetics of the
RT domestic horse.";
RL Science 326:865-867(2009).
RN [2] {ECO:0000313|Ensembl:ENSECAP00000033973.2}
RP IDENTIFICATION.
RC STRAIN=Thoroughbred {ECO:0000313|Ensembl:ENSECAP00000033973.2};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
CC -!- SIMILARITY: Belongs to the JIP scaffold family.
CC {ECO:0000256|ARBA:ARBA00009866}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR AlphaFoldDB; A0A3Q2HH79; -.
DR Ensembl; ENSECAT00000055245.2; ENSECAP00000033973.2; ENSECAG00000007619.4.
DR VGNC; VGNC:59269; MAPK8IP1.
DR GeneTree; ENSGT00940000157089; -.
DR Proteomes; UP000002281; Chromosome 12.
DR Bgee; ENSECAG00000007619; Expressed in prefrontal cortex and 21 other cell types or tissues.
DR ExpressionAtlas; A0A3Q2HH79; baseline.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0046328; P:regulation of JNK cascade; IEA:InterPro.
DR CDD; cd01212; PTB_JIP; 1.
DR CDD; cd11943; SH3_JIP1; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR Gene3D; 2.30.30.40; SH3 Domains; 1.
DR InterPro; IPR047178; JIP1_scaffold.
DR InterPro; IPR035638; JIP1_SH3.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR006020; PTB/PI_dom.
DR InterPro; IPR036028; SH3-like_dom_sf.
DR InterPro; IPR001452; SH3_domain.
DR PANTHER; PTHR47437:SF3; C-JUN-AMINO-TERMINAL KINASE-INTERACTING PROTEIN 1; 1.
DR PANTHER; PTHR47437; JNK-INTERACTING PROTEIN 1-LIKE PROTEIN; 1.
DR Pfam; PF00640; PID; 1.
DR Pfam; PF14604; SH3_9; 1.
DR SMART; SM00462; PTB; 1.
DR SMART; SM00326; SH3; 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR SUPFAM; SSF50044; SH3-domain; 1.
DR PROSITE; PS01179; PID; 1.
DR PROSITE; PS50002; SH3; 1.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000002281};
KW SH3 domain {ECO:0000256|ARBA:ARBA00022443, ECO:0000256|PROSITE-
KW ProRule:PRU00192}.
FT DOMAIN 474..535
FT /note="SH3"
FT /evidence="ECO:0000259|PROSITE:PS50002"
FT DOMAIN 552..686
FT /note="PID"
FT /evidence="ECO:0000259|PROSITE:PS01179"
FT REGION 90..357
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 415..436
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 152..189
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 211..228
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 245..261
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 697 AA; 76744 MW; B2F149D5A5705508 CRC64;
MQLVLKMDSS PDNDSWLEDQ WERWLTHDIS LEEFEDEDLS EITDECGISL QCKDTLSLRP
PRAGLLSGGA VGAGSRLQAE MLQMDLIDAA GDTPGAEDDE EEDEEERAAR RPGAGPPEAE
PCQEPAPRGP GQGQGPGGGD TYRPKRPTTL NLFPQVPRSQ DTLNNNSLGK KHSWQDRVSR
SSSPLKTGEQ TPPHEHICLS DELPPQGSPA PTKDRGTSTD SPCRRSAATQ MAPPSGPPAA
PAGGRGHSHR DRIHYQADVR LEATEEIYLT PVQRPSDPAE PTSAFLPPAE SRMSVSSDPD
PAAYPSAAGR PHPSISEEDE GFDCLSSPDR AEPPGSGWRG SLGEPPPPPR ASLSSDTSAL
SYDSVKYTLV VDEHAQLELV SLRPCFGDYS DESDSATVYD NCASASSPYE SAIGEEYEEA
PRPRPPACLS EDSTPDEPDV HFSKKFLNVF MSGRSRSSSA ESFGLFSCVI NGEEQEQTHR
AIFRFVPRHE DELELEVDDP LLVELQAEDY WYDAYNMRTG ARGIFPAYYA IEVAKEPEHM
AALTKNSDWV DQFRAKFLGS VQVPYHKGND VLCAAMQKIA TTRRLTVHFN PPSSCVLEIS
VRGVKIGVKA DDAQEAKGNK CSHFFQLKNI SFCGYHPKNN KYFGFITKHP ADHRFACHVF
VSEESTKALA ESVGRAFQQF YKQFVEYTCP TEDIYLE
//
