ID A0A3Q2HI09_HORSE Unreviewed; 523 AA.
AC A0A3Q2HI09;
DT 10-APR-2019, integrated into UniProtKB/TrEMBL.
DT 13-SEP-2023, sequence version 3.
DT 27-MAR-2024, entry version 20.
DE SubName: Full=Ankyrin repeat domain 42 {ECO:0000313|Ensembl:ENSECAP00000034143.3};
GN Name=ANKRD42 {ECO:0000313|VGNC:VGNC:55780};
OS Equus caballus (Horse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Perissodactyla; Equidae; Equus.
OX NCBI_TaxID=9796 {ECO:0000313|Ensembl:ENSECAP00000034143.3, ECO:0000313|Proteomes:UP000002281};
RN [1] {ECO:0000313|Ensembl:ENSECAP00000034143.3, ECO:0000313|Proteomes:UP000002281}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Thoroughbred {ECO:0000313|Ensembl:ENSECAP00000034143.3,
RC ECO:0000313|Proteomes:UP000002281};
RX PubMed=19892987; DOI=10.1126/science.1178158;
RG Broad Institute Genome Sequencing Platform;
RG Broad Institute Whole Genome Assembly Team;
RA Wade C.M., Giulotto E., Sigurdsson S., Zoli M., Gnerre S., Imsland F.,
RA Lear T.L., Adelson D.L., Bailey E., Bellone R.R., Bloecker H., Distl O.,
RA Edgar R.C., Garber M., Leeb T., Mauceli E., MacLeod J.N., Penedo M.C.T.,
RA Raison J.M., Sharpe T., Vogel J., Andersson L., Antczak D.F., Biagi T.,
RA Binns M.M., Chowdhary B.P., Coleman S.J., Della Valle G., Fryc S.,
RA Guerin G., Hasegawa T., Hill E.W., Jurka J., Kiialainen A., Lindgren G.,
RA Liu J., Magnani E., Mickelson J.R., Murray J., Nergadze S.G., Onofrio R.,
RA Pedroni S., Piras M.F., Raudsepp T., Rocchi M., Roeed K.H., Ryder O.A.,
RA Searle S., Skow L., Swinburne J.E., Syvaenen A.C., Tozaki T., Valberg S.J.,
RA Vaudin M., White J.R., Zody M.C., Lander E.S., Lindblad-Toh K.;
RT "Genome sequence, comparative analysis, and population genetics of the
RT domestic horse.";
RL Science 326:865-867(2009).
RN [2] {ECO:0000313|Ensembl:ENSECAP00000034143.3}
RP IDENTIFICATION.
RC STRAIN=Thoroughbred {ECO:0000313|Ensembl:ENSECAP00000034143.3};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR AlphaFoldDB; A0A3Q2HI09; -.
DR STRING; 9796.ENSECAP00000034143; -.
DR PaxDb; 9796-ENSECAP00000034143; -.
DR Ensembl; ENSECAT00000047003.3; ENSECAP00000034143.3; ENSECAG00000018421.4.
DR VGNC; VGNC:55780; ANKRD42.
DR GeneTree; ENSGT00940000154216; -.
DR InParanoid; A0A3Q2HI09; -.
DR Proteomes; UP000002281; Chromosome 7.
DR Bgee; ENSECAG00000018421; Expressed in oviduct epithelium and 23 other cell types or tissues.
DR ExpressionAtlas; A0A3Q2HI09; baseline.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0051059; F:NF-kappaB binding; IBA:GO_Central.
DR Gene3D; 1.25.40.20; Ankyrin repeat-containing domain; 3.
DR InterPro; IPR002110; Ankyrin_rpt.
DR InterPro; IPR036770; Ankyrin_rpt-contain_sf.
DR InterPro; IPR018247; EF_Hand_1_Ca_BS.
DR PANTHER; PTHR24201; ANK_REP_REGION DOMAIN-CONTAINING PROTEIN; 1.
DR PANTHER; PTHR24201:SF2; ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 42; 1.
DR Pfam; PF00023; Ank; 1.
DR Pfam; PF12796; Ank_2; 1.
DR Pfam; PF13637; Ank_4; 1.
DR SMART; SM00248; ANK; 8.
DR SUPFAM; SSF48403; Ankyrin repeat; 1.
DR PROSITE; PS50297; ANK_REP_REGION; 5.
DR PROSITE; PS50088; ANK_REPEAT; 5.
DR PROSITE; PS00018; EF_HAND_1; 1.
PE 4: Predicted;
KW ANK repeat {ECO:0000256|ARBA:ARBA00023043, ECO:0000256|PROSITE-
KW ProRule:PRU00023}; Coiled coil {ECO:0000256|SAM:Coils};
KW Reference proteome {ECO:0000313|Proteomes:UP000002281};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT REPEAT 59..91
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 92..124
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 125..157
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 191..223
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 297..329
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REGION 1..21
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 427..477
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 1..18
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 523 AA; 58371 MW; A0A8C2AF2F16C4D6 CRC64;
MPGVPGSGPS TSSAETATPG VRKKVHFGSI HDAIRAGDVK RLSEIVERGA SINEVDILHK
FTPLHWAAHS GSLECLHWLL WHGADIAQAT TRGWTAAHIA AIRGQDACMQ ALIINGANLA
AQDDRGCTPL HLAATHGHSF TLQIMLQSGV DPSVTDKREW KPVHYAAFHG RLGCLQLLVK
WGCGIEDVDY NGNLPVHLAA MEGHLHCFKF LLSRMSSATQ ALKAFNDNGE NVSDLAQRFF
KQNILQFIQG AEYEGNDPKD QETLAFPGHV AAFKGDLEML KKLIEDGVIN INERDNNGST
LLHKAAGQGH IECLQWIIKM GADSNITNKA GEKPSDVAKR FAHLAAVKLL EGLQKYDIDD
ENEIDENDLK FFIRHGVEGS TDAKDDLCLT ESDKTDARMR AYKKIVELRH LLEIAESNYK
HLGGITEEDL KQKKERLKSE RTVKELQDQL EYERLRREKL ECQLDGYRAE VDQLRETLEK
IQVPNFVAVE DDSSCESSKE KRRMKKKMSS GGVFVRRMHP TCT
//
