ID A0A3Q2HIL7_HORSE Unreviewed; 634 AA.
AC A0A3Q2HIL7;
DT 10-APR-2019, integrated into UniProtKB/TrEMBL.
DT 13-SEP-2023, sequence version 3.
DT 27-MAR-2024, entry version 20.
DE SubName: Full=X-prolyl aminopeptidase 1 {ECO:0000313|Ensembl:ENSECAP00000033052.3};
GN Name=XPNPEP1 {ECO:0000313|VGNC:VGNC:25072};
OS Equus caballus (Horse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Perissodactyla; Equidae; Equus.
OX NCBI_TaxID=9796 {ECO:0000313|Ensembl:ENSECAP00000033052.3, ECO:0000313|Proteomes:UP000002281};
RN [1] {ECO:0000313|Ensembl:ENSECAP00000033052.3, ECO:0000313|Proteomes:UP000002281}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Thoroughbred {ECO:0000313|Ensembl:ENSECAP00000033052.3,
RC ECO:0000313|Proteomes:UP000002281};
RX PubMed=19892987; DOI=10.1126/science.1178158;
RG Broad Institute Genome Sequencing Platform;
RG Broad Institute Whole Genome Assembly Team;
RA Wade C.M., Giulotto E., Sigurdsson S., Zoli M., Gnerre S., Imsland F.,
RA Lear T.L., Adelson D.L., Bailey E., Bellone R.R., Bloecker H., Distl O.,
RA Edgar R.C., Garber M., Leeb T., Mauceli E., MacLeod J.N., Penedo M.C.T.,
RA Raison J.M., Sharpe T., Vogel J., Andersson L., Antczak D.F., Biagi T.,
RA Binns M.M., Chowdhary B.P., Coleman S.J., Della Valle G., Fryc S.,
RA Guerin G., Hasegawa T., Hill E.W., Jurka J., Kiialainen A., Lindgren G.,
RA Liu J., Magnani E., Mickelson J.R., Murray J., Nergadze S.G., Onofrio R.,
RA Pedroni S., Piras M.F., Raudsepp T., Rocchi M., Roeed K.H., Ryder O.A.,
RA Searle S., Skow L., Swinburne J.E., Syvaenen A.C., Tozaki T., Valberg S.J.,
RA Vaudin M., White J.R., Zody M.C., Lander E.S., Lindblad-Toh K.;
RT "Genome sequence, comparative analysis, and population genetics of the
RT domestic horse.";
RL Science 326:865-867(2009).
RN [2] {ECO:0000313|Ensembl:ENSECAP00000033052.3}
RP IDENTIFICATION.
RC STRAIN=Thoroughbred {ECO:0000313|Ensembl:ENSECAP00000033052.3};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the peptidase M24B family.
CC {ECO:0000256|ARBA:ARBA00008766, ECO:0000256|RuleBase:RU000590}.
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DR AlphaFoldDB; A0A3Q2HIL7; -.
DR Ensembl; ENSECAT00000047876.3; ENSECAP00000033052.3; ENSECAG00000022579.4.
DR VGNC; VGNC:25072; XPNPEP1.
DR GeneTree; ENSGT00940000157716; -.
DR Proteomes; UP000002281; Chromosome 1.
DR Bgee; ENSECAG00000022579; Expressed in synovial membrane of synovial joint and 23 other cell types or tissues.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0070006; F:metalloaminopeptidase activity; IEA:InterPro.
DR CDD; cd01085; APP; 1.
DR Gene3D; 3.90.230.10; Creatinase/methionine aminopeptidase superfamily; 1.
DR Gene3D; 3.40.350.10; Creatinase/prolidase N-terminal domain; 2.
DR InterPro; IPR029149; Creatin/AminoP/Spt16_NTD.
DR InterPro; IPR036005; Creatinase/aminopeptidase-like.
DR InterPro; IPR000587; Creatinase_N.
DR InterPro; IPR000994; Pept_M24.
DR InterPro; IPR033740; Pept_M24B.
DR InterPro; IPR032416; Peptidase_M24_C.
DR InterPro; IPR001131; Peptidase_M24B_aminopep-P_CS.
DR PANTHER; PTHR43763; XAA-PRO AMINOPEPTIDASE 1; 1.
DR PANTHER; PTHR43763:SF6; XAA-PRO AMINOPEPTIDASE 1; 1.
DR Pfam; PF01321; Creatinase_N; 1.
DR Pfam; PF16189; Creatinase_N_2; 1.
DR Pfam; PF00557; Peptidase_M24; 1.
DR Pfam; PF16188; Peptidase_M24_C; 1.
DR SUPFAM; SSF55920; Creatinase/aminopeptidase; 1.
DR SUPFAM; SSF53092; Creatinase/prolidase N-terminal domain; 1.
DR PROSITE; PS00491; PROLINE_PEPTIDASE; 1.
PE 1: Evidence at protein level;
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723,
KW ECO:0000256|RuleBase:RU000590};
KW Proteomics identification {ECO:0007829|PeptideAtlas:A0A3Q2HIL7};
KW Reference proteome {ECO:0000313|Proteomes:UP000002281}.
FT DOMAIN 55..191
FT /note="Creatinase N-terminal"
FT /evidence="ECO:0000259|Pfam:PF01321"
FT DOMAIN 339..553
FT /note="Peptidase M24"
FT /evidence="ECO:0000259|Pfam:PF00557"
FT DOMAIN 568..630
FT /note="Peptidase M24 C-terminal"
FT /evidence="ECO:0000259|Pfam:PF16188"
SQ SEQUENCE 634 AA; 70926 MW; 8F78F3FD367E00A8 CRC64;
MAASRKAPRV RANHQDFLLK NLRIIEPNEV THTGDPGVET DSRMAPKVTS ELLRQLRQAM
RNLEYVTEPI QAYIIPSGDA HQSEYIAPCD CRRAFVSGFD GSAGTAIITE EHAAMWTDGR
YFLQAAKQMD SNWTLMKMGL KDTPTQEDWL VSVLPEGSRV GVDPLIIPTD YWKKMAKVLR
SAGHHLIPVK ENLVDKIWTD RPERPCKPLL TLGLDYTGLF NLRGSDVEHN PVFFSYAVIG
LETIMLFIDG DRIDTPSVKE HLLLDLGLEA EYRIQVLPYK SILSKLKALC ADLSPREKVW
VSDKASYAVS EAIPKDHRCC MPYTPICIAK AVKNSAESEG MRRAHIKDAV ALCELFNWLE
KEVPKGGVTE ISAADKAEEF RRQQADFVDL SFPTISSTGP NGAIIHYAPV PETNRTLSLD
EVYLIDSGAQ YKDGTTDVTR TMHFGTPKAY EKECFTYVLK GHIAVSAAVF PTGTKGHLLD
SFARSALWDS GLDYLHGTGH GVGSFLNVHE GPCGISYKTF SDEPLEAGMI VTDEPGYYED
GAFGIRIENV VLVVPVKTKY NFNNRGSLTF EPLTLVPIQT KMIDVDSLTD KECDWLNNYH
LTCRDVVGKE LQKQGRQEAL EWLIRETQPI SRQH
//
