ID A0A3Q2HJG7_HORSE Unreviewed; 248 AA.
AC A0A3Q2HJG7;
DT 10-APR-2019, integrated into UniProtKB/TrEMBL.
DT 10-APR-2019, sequence version 1.
DT 27-MAR-2024, entry version 21.
DE RecName: Full=Interleukin family protein {ECO:0000256|RuleBase:RU368043};
GN Name=IL20 {ECO:0000313|VGNC:VGNC:19013};
OS Equus caballus (Horse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Perissodactyla; Equidae; Equus.
OX NCBI_TaxID=9796 {ECO:0000313|Ensembl:ENSECAP00000034814.1, ECO:0000313|Proteomes:UP000002281};
RN [1] {ECO:0000313|Ensembl:ENSECAP00000034814.1, ECO:0000313|Proteomes:UP000002281}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Thoroughbred {ECO:0000313|Ensembl:ENSECAP00000034814.1,
RC ECO:0000313|Proteomes:UP000002281};
RX PubMed=19892987; DOI=10.1126/science.1178158;
RG Broad Institute Genome Sequencing Platform;
RG Broad Institute Whole Genome Assembly Team;
RA Wade C.M., Giulotto E., Sigurdsson S., Zoli M., Gnerre S., Imsland F.,
RA Lear T.L., Adelson D.L., Bailey E., Bellone R.R., Bloecker H., Distl O.,
RA Edgar R.C., Garber M., Leeb T., Mauceli E., MacLeod J.N., Penedo M.C.T.,
RA Raison J.M., Sharpe T., Vogel J., Andersson L., Antczak D.F., Biagi T.,
RA Binns M.M., Chowdhary B.P., Coleman S.J., Della Valle G., Fryc S.,
RA Guerin G., Hasegawa T., Hill E.W., Jurka J., Kiialainen A., Lindgren G.,
RA Liu J., Magnani E., Mickelson J.R., Murray J., Nergadze S.G., Onofrio R.,
RA Pedroni S., Piras M.F., Raudsepp T., Rocchi M., Roeed K.H., Ryder O.A.,
RA Searle S., Skow L., Swinburne J.E., Syvaenen A.C., Tozaki T., Valberg S.J.,
RA Vaudin M., White J.R., Zody M.C., Lander E.S., Lindblad-Toh K.;
RT "Genome sequence, comparative analysis, and population genetics of the
RT domestic horse.";
RL Science 326:865-867(2009).
RN [2] {ECO:0000313|Ensembl:ENSECAP00000034814.1}
RP IDENTIFICATION.
RC STRAIN=Thoroughbred {ECO:0000313|Ensembl:ENSECAP00000034814.1};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- FUNCTION: Immune regulatory cytokine. {ECO:0000256|RuleBase:RU368043}.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|ARBA:ARBA00004613,
CC ECO:0000256|RuleBase:RU368043}.
CC -!- SIMILARITY: Belongs to the IL-10 family.
CC {ECO:0000256|ARBA:ARBA00008813, ECO:0000256|RuleBase:RU368043}.
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DR AlphaFoldDB; A0A3Q2HJG7; -.
DR SMR; A0A3Q2HJG7; -.
DR STRING; 9796.ENSECAP00000034814; -.
DR PaxDb; 9796-ENSECAP00000034814; -.
DR Ensembl; ENSECAT00000035502.2; ENSECAP00000034814.1; ENSECAG00000009603.4.
DR VGNC; VGNC:19013; IL20.
DR GeneTree; ENSGT00950000183124; -.
DR InParanoid; A0A3Q2HJG7; -.
DR Proteomes; UP000002281; Chromosome 5.
DR Bgee; ENSECAG00000009603; Expressed in triceps brachii and 2 other cell types or tissues.
DR ExpressionAtlas; A0A3Q2HJG7; baseline.
DR GO; GO:0005615; C:extracellular space; IEA:UniProtKB-UniRule.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0005125; F:cytokine activity; IEA:UniProtKB-UniRule.
DR Gene3D; 1.20.1250.10; -; 1.
DR InterPro; IPR009079; 4_helix_cytokine-like_core.
DR InterPro; IPR020443; IL-10/19/20/22/24/26_fam.
DR InterPro; IPR020444; IL-24.
DR PANTHER; PTHR48394; INTERLEUKIN-19-RELATED; 1.
DR PANTHER; PTHR48394:SF4; INTERLEUKIN-20; 1.
DR Pfam; PF00726; IL10; 1.
DR PRINTS; PR01937; INTRLEUKIN24.
DR SMART; SM00188; IL10; 1.
DR SUPFAM; SSF47266; 4-helical cytokines; 1.
PE 3: Inferred from homology;
KW Cytokine {ECO:0000256|ARBA:ARBA00022514, ECO:0000256|RuleBase:RU368043};
KW Disulfide bond {ECO:0000256|PIRSR:PIRSR620443-50};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000002281};
KW Secreted {ECO:0000256|ARBA:ARBA00022525, ECO:0000256|RuleBase:RU368043};
KW Signal {ECO:0000256|ARBA:ARBA00022729};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 77..97
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DISULFID 105..198
FT /evidence="ECO:0000256|PIRSR:PIRSR620443-50"
FT DISULFID 152..206
FT /evidence="ECO:0000256|PIRSR:PIRSR620443-50"
FT DISULFID 152..204
FT /evidence="ECO:0000256|PIRSR:PIRSR620443-51"
FT DISULFID 153..206
FT /evidence="ECO:0000256|PIRSR:PIRSR620443-51"
SQ SEQUENCE 248 AA; 27640 MW; 3AB4F6624D3F6D36 CRC64;
MSSSVYSLQV PAAPGFVCRA MTTGLGWGQD KGAGICSTNS HPDPEQAQEG KASLPGGSAV
LLTPVVSRLQ HKMDGSGLAL CLLAAVFCLF WTPSAGLKTL HLGSCVITTN LQEMRNGFSE
IRDRVLAEDE IIDVRILRKM VSLQDTEPAG QCCLLRHVLR LYLDKVFKNY QTPDHHILRK
LSSLANSFLT IKKDLRLCHD RMTCPCWEEA MEKYSRILSH FEELKPREAV VKALGELDIL
LRWMEEAE
//
