ID A0A3Q2HJN8_HORSE Unreviewed; 260 AA.
AC A0A3Q2HJN8;
DT 10-APR-2019, integrated into UniProtKB/TrEMBL.
DT 13-SEP-2023, sequence version 3.
DT 27-MAR-2024, entry version 21.
DE RecName: Full=Interleukin-1 {ECO:0000256|RuleBase:RU003753};
GN Name=IL1RN {ECO:0000313|Ensembl:ENSECAP00000034905.3,
GN ECO:0000313|VGNC:VGNC:51326};
OS Equus caballus (Horse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Perissodactyla; Equidae; Equus.
OX NCBI_TaxID=9796 {ECO:0000313|Ensembl:ENSECAP00000034905.3, ECO:0000313|Proteomes:UP000002281};
RN [1] {ECO:0000313|Ensembl:ENSECAP00000034905.3, ECO:0000313|Proteomes:UP000002281}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Thoroughbred {ECO:0000313|Ensembl:ENSECAP00000034905.3,
RC ECO:0000313|Proteomes:UP000002281};
RX PubMed=19892987; DOI=10.1126/science.1178158;
RG Broad Institute Genome Sequencing Platform;
RG Broad Institute Whole Genome Assembly Team;
RA Wade C.M., Giulotto E., Sigurdsson S., Zoli M., Gnerre S., Imsland F.,
RA Lear T.L., Adelson D.L., Bailey E., Bellone R.R., Bloecker H., Distl O.,
RA Edgar R.C., Garber M., Leeb T., Mauceli E., MacLeod J.N., Penedo M.C.T.,
RA Raison J.M., Sharpe T., Vogel J., Andersson L., Antczak D.F., Biagi T.,
RA Binns M.M., Chowdhary B.P., Coleman S.J., Della Valle G., Fryc S.,
RA Guerin G., Hasegawa T., Hill E.W., Jurka J., Kiialainen A., Lindgren G.,
RA Liu J., Magnani E., Mickelson J.R., Murray J., Nergadze S.G., Onofrio R.,
RA Pedroni S., Piras M.F., Raudsepp T., Rocchi M., Roeed K.H., Ryder O.A.,
RA Searle S., Skow L., Swinburne J.E., Syvaenen A.C., Tozaki T., Valberg S.J.,
RA Vaudin M., White J.R., Zody M.C., Lander E.S., Lindblad-Toh K.;
RT "Genome sequence, comparative analysis, and population genetics of the
RT domestic horse.";
RL Science 326:865-867(2009).
RN [2] {ECO:0000313|Ensembl:ENSECAP00000034905.3}
RP IDENTIFICATION.
RC STRAIN=Thoroughbred {ECO:0000313|Ensembl:ENSECAP00000034905.3};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- FUNCTION: Anti-inflammatory antagonist of interleukin-1 family of
CC proinflammatory cytokines such as interleukin-1beta/IL1B and
CC interleukin-1alpha/IL1A. Protects from immune dysregulation and
CC uncontrolled systemic inflammation triggered by IL1 for a range of
CC innate stimulatory agents such as pathogens.
CC {ECO:0000256|ARBA:ARBA00034096}.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|ARBA:ARBA00004613,
CC ECO:0000256|RuleBase:RU003753}.
CC -!- SIMILARITY: Belongs to the IL-1 family. {ECO:0000256|ARBA:ARBA00010448,
CC ECO:0000256|RuleBase:RU003753}.
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DR AlphaFoldDB; A0A3Q2HJN8; -.
DR Ensembl; ENSECAT00000052120.3; ENSECAP00000034905.3; ENSECAG00000027864.3.
DR CTD; 3557; -.
DR VGNC; VGNC:51326; IL1RN.
DR GeneTree; ENSGT00950000182943; -.
DR OrthoDB; 4292752at2759; -.
DR Proteomes; UP000002281; Chromosome 15.
DR Bgee; ENSECAG00000027864; Expressed in blood and 18 other cell types or tissues.
DR GO; GO:0005615; C:extracellular space; IEA:InterPro.
DR GO; GO:0005125; F:cytokine activity; IEA:UniProtKB-UniRule.
DR GO; GO:0005149; F:interleukin-1 receptor binding; IEA:UniProtKB-UniRule.
DR GO; GO:0006955; P:immune response; IEA:InterPro.
DR GO; GO:0006954; P:inflammatory response; IEA:InterPro.
DR CDD; cd00100; IL1; 1.
DR Gene3D; 2.80.10.50; -; 1.
DR InterPro; IPR020877; IL-1_CS.
DR InterPro; IPR000975; IL-1_fam.
DR InterPro; IPR003297; IL-1RA/IL-36.
DR InterPro; IPR008996; IL1/FGF.
DR PANTHER; PTHR10078; INTERLEUKIN-1 FAMILY MEMBER; 1.
DR PANTHER; PTHR10078:SF28; INTERLEUKIN-1 RECEPTOR ANTAGONIST PROTEIN; 1.
DR Pfam; PF00340; IL1; 1.
DR PRINTS; PR00264; INTERLEUKIN1.
DR PRINTS; PR01360; INTRLEUKIN1X.
DR SMART; SM00125; IL1; 1.
DR SUPFAM; SSF50353; Cytokine; 1.
DR PROSITE; PS00253; INTERLEUKIN_1; 1.
PE 3: Inferred from homology;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Reference proteome {ECO:0000313|Proteomes:UP000002281};
KW Secreted {ECO:0000256|RuleBase:RU003753};
KW Signal {ECO:0000256|ARBA:ARBA00022729}.
SQ SEQUENCE 260 AA; 28732 MW; 02E6678996B01B74 CRC64;
MCHLQFYAEK NQLASVSLSH PSGSWACSPP QVTSPASVCG KAGCSSSSYS AHVVGKEGAA
LSWEVLVAQV PPGCSSFPCS GSVWSQRLED LTRLRILQAL PMALETACHP LGKRPCKMQA
FRIWDVNQKT FYMRNNQLVA GYLQESNTKL QEKIDVVPIE PDALFLGLHG RKLCLACVKS
GDEIRFQLEA VNITDLSKNK EENKRFTFIR SNSGPTTSFE SAACPGWFLC TAQEADRPVS
LTNKPKESFM VTKFYLQEDQ
//
