ID A0A3Q2HJX2_HORSE Unreviewed; 427 AA.
AC A0A3Q2HJX2;
DT 10-APR-2019, integrated into UniProtKB/TrEMBL.
DT 10-APR-2019, sequence version 1.
DT 27-MAR-2024, entry version 22.
DE RecName: Full=Hydroxysteroid dehydrogenase-like protein 2 {ECO:0000256|ARBA:ARBA00040243};
GN Name=HSDL2 {ECO:0000313|Ensembl:ENSECAP00000034859.1,
GN ECO:0000313|VGNC:VGNC:18891};
OS Equus caballus (Horse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Perissodactyla; Equidae; Equus.
OX NCBI_TaxID=9796 {ECO:0000313|Ensembl:ENSECAP00000034859.1, ECO:0000313|Proteomes:UP000002281};
RN [1] {ECO:0000313|Ensembl:ENSECAP00000034859.1, ECO:0000313|Proteomes:UP000002281}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Thoroughbred {ECO:0000313|Ensembl:ENSECAP00000034859.1,
RC ECO:0000313|Proteomes:UP000002281};
RX PubMed=19892987; DOI=10.1126/science.1178158;
RG Broad Institute Genome Sequencing Platform;
RG Broad Institute Whole Genome Assembly Team;
RA Wade C.M., Giulotto E., Sigurdsson S., Zoli M., Gnerre S., Imsland F.,
RA Lear T.L., Adelson D.L., Bailey E., Bellone R.R., Bloecker H., Distl O.,
RA Edgar R.C., Garber M., Leeb T., Mauceli E., MacLeod J.N., Penedo M.C.T.,
RA Raison J.M., Sharpe T., Vogel J., Andersson L., Antczak D.F., Biagi T.,
RA Binns M.M., Chowdhary B.P., Coleman S.J., Della Valle G., Fryc S.,
RA Guerin G., Hasegawa T., Hill E.W., Jurka J., Kiialainen A., Lindgren G.,
RA Liu J., Magnani E., Mickelson J.R., Murray J., Nergadze S.G., Onofrio R.,
RA Pedroni S., Piras M.F., Raudsepp T., Rocchi M., Roeed K.H., Ryder O.A.,
RA Searle S., Skow L., Swinburne J.E., Syvaenen A.C., Tozaki T., Valberg S.J.,
RA Vaudin M., White J.R., Zody M.C., Lander E.S., Lindblad-Toh K.;
RT "Genome sequence, comparative analysis, and population genetics of the
RT domestic horse.";
RL Science 326:865-867(2009).
RN [2] {ECO:0000313|Ensembl:ENSECAP00000034859.1}
RP IDENTIFICATION.
RC STRAIN=Thoroughbred {ECO:0000313|Ensembl:ENSECAP00000034859.1};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- FUNCTION: Has apparently no steroid dehydrogenase activity.
CC {ECO:0000256|ARBA:ARBA00037788}.
CC -!- SUBCELLULAR LOCATION: Peroxisome {ECO:0000256|ARBA:ARBA00004275}.
CC -!- SIMILARITY: Belongs to the short-chain dehydrogenases/reductases (SDR)
CC family. {ECO:0000256|ARBA:ARBA00006484}.
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DR AlphaFoldDB; A0A3Q2HJX2; -.
DR Ensembl; ENSECAT00000048634.3; ENSECAP00000034859.1; ENSECAG00000024878.4.
DR VGNC; VGNC:18891; HSDL2.
DR GeneTree; ENSGT00940000156729; -.
DR Proteomes; UP000002281; Chromosome 25.
DR Bgee; ENSECAG00000024878; Expressed in gluteus medius and 23 other cell types or tissues.
DR ExpressionAtlas; A0A3Q2HJX2; baseline.
DR GO; GO:0005739; C:mitochondrion; IEA:Ensembl.
DR GO; GO:0005777; C:peroxisome; IEA:UniProtKB-SubCell.
DR GO; GO:0016491; F:oxidoreductase activity; IEA:UniProtKB-KW.
DR CDD; cd09762; HSDL2_SDR_c; 1.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR Gene3D; 3.30.1050.10; SCP2 sterol-binding domain; 1.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR InterPro; IPR003033; SCP2_sterol-bd_dom.
DR InterPro; IPR036527; SCP2_sterol-bd_dom_sf.
DR InterPro; IPR002347; SDR_fam.
DR PANTHER; PTHR42808; HYDROXYSTEROID DEHYDROGENASE-LIKE PROTEIN 2; 1.
DR PANTHER; PTHR42808:SF3; HYDROXYSTEROID DEHYDROGENASE-LIKE PROTEIN 2; 1.
DR Pfam; PF00106; adh_short; 1.
DR Pfam; PF02036; SCP2; 1.
DR PRINTS; PR00081; GDHRDH.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
DR SUPFAM; SSF55718; SCP-like; 1.
PE 1: Evidence at protein level;
KW NADP {ECO:0000256|ARBA:ARBA00022857};
KW Oxidoreductase {ECO:0000256|ARBA:ARBA00023002};
KW Peroxisome {ECO:0000256|ARBA:ARBA00023140};
KW Proteomics identification {ECO:0007829|PeptideAtlas:A0A3Q2HJX2};
KW Reference proteome {ECO:0000313|Proteomes:UP000002281}.
FT DOMAIN 327..420
FT /note="SCP2"
FT /evidence="ECO:0000259|Pfam:PF02036"
FT REGION 291..318
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 291..311
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 427 AA; 46605 MW; EB3921CCA1B2A509 CRC64;
MAKRLKQLKR VNGQKKLAGC TVFITGASRG IGKAIALKAA KDGANIVIAA KTTHPHPRLS
GTIYTAAEEV EAAGGKALPC VVDVRDEQQI NNAVERAVEK FGGIDVLVNN ASAISLTNTL
ETPTKRVDLM MNVNTRGTYL TSKACIPYLK KSKIAHILNL SPPLNLNPLW FKQHCAYTIA
KYGMSMCVLG MAEEFKGEIA VNALWPKTAI HTAAMDMLGG SGIESQCRKV DIIADAAYSI
FKRPKTFTGN FVIDENILKD EGVENFDIYA VKPGHPLIPD FFLDEQPDTI TKKMESRGPP
PELREEKSQP PPKPRSGAVE ETFRIVKDSL SDDVVKATQA IYQFELSGED GGTWFLDLKS
QGGNVGYGEP SDRADVVMSM STEDFVKMFS GKLKPTMAFM SGKLKIKGNM ALAIKLEKLM
SQMNAKL
//
