ID A0A3Q2HKV2_HORSE Unreviewed; 421 AA.
AC A0A3Q2HKV2;
DT 10-APR-2019, integrated into UniProtKB/TrEMBL.
DT 13-SEP-2023, sequence version 2.
DT 27-MAR-2024, entry version 20.
DE RecName: Full=Cytohesin-2 {ECO:0000256|ARBA:ARBA00040245};
DE AltName: Full=PH, SEC7 and coiled-coil domain-containing protein 2 {ECO:0000256|ARBA:ARBA00042728};
GN Name=CYTH2 {ECO:0000313|Ensembl:ENSECAP00000035380.2,
GN ECO:0000313|VGNC:VGNC:51020};
OS Equus caballus (Horse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Perissodactyla; Equidae; Equus.
OX NCBI_TaxID=9796 {ECO:0000313|Ensembl:ENSECAP00000035380.2, ECO:0000313|Proteomes:UP000002281};
RN [1] {ECO:0000313|Ensembl:ENSECAP00000035380.2, ECO:0000313|Proteomes:UP000002281}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Thoroughbred {ECO:0000313|Ensembl:ENSECAP00000035380.2,
RC ECO:0000313|Proteomes:UP000002281};
RX PubMed=19892987; DOI=10.1126/science.1178158;
RG Broad Institute Genome Sequencing Platform;
RG Broad Institute Whole Genome Assembly Team;
RA Wade C.M., Giulotto E., Sigurdsson S., Zoli M., Gnerre S., Imsland F.,
RA Lear T.L., Adelson D.L., Bailey E., Bellone R.R., Bloecker H., Distl O.,
RA Edgar R.C., Garber M., Leeb T., Mauceli E., MacLeod J.N., Penedo M.C.T.,
RA Raison J.M., Sharpe T., Vogel J., Andersson L., Antczak D.F., Biagi T.,
RA Binns M.M., Chowdhary B.P., Coleman S.J., Della Valle G., Fryc S.,
RA Guerin G., Hasegawa T., Hill E.W., Jurka J., Kiialainen A., Lindgren G.,
RA Liu J., Magnani E., Mickelson J.R., Murray J., Nergadze S.G., Onofrio R.,
RA Pedroni S., Piras M.F., Raudsepp T., Rocchi M., Roeed K.H., Ryder O.A.,
RA Searle S., Skow L., Swinburne J.E., Syvaenen A.C., Tozaki T., Valberg S.J.,
RA Vaudin M., White J.R., Zody M.C., Lander E.S., Lindblad-Toh K.;
RT "Genome sequence, comparative analysis, and population genetics of the
RT domestic horse.";
RL Science 326:865-867(2009).
RN [2] {ECO:0000313|Ensembl:ENSECAP00000035380.2}
RP IDENTIFICATION.
RC STRAIN=Thoroughbred {ECO:0000313|Ensembl:ENSECAP00000035380.2};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004202};
CC Peripheral membrane protein {ECO:0000256|ARBA:ARBA00004202}. Membrane
CC {ECO:0000256|ARBA:ARBA00004170}; Peripheral membrane protein
CC {ECO:0000256|ARBA:ARBA00004170}.
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DR AlphaFoldDB; A0A3Q2HKV2; -.
DR STRING; 9796.ENSECAP00000035380; -.
DR PaxDb; 9796-ENSECAP00000035380; -.
DR Ensembl; ENSECAT00000059413.2; ENSECAP00000035380.2; ENSECAG00000009878.4.
DR VGNC; VGNC:51020; CYTH2.
DR GeneTree; ENSGT00940000160074; -.
DR InParanoid; A0A3Q2HKV2; -.
DR Proteomes; UP000002281; Chromosome 10.
DR Bgee; ENSECAG00000009878; Expressed in retina and 23 other cell types or tissues.
DR ExpressionAtlas; A0A3Q2HKV2; baseline.
DR GO; GO:0042995; C:cell projection; IEA:UniProtKB-KW.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-KW.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:InterPro.
DR GO; GO:0032012; P:regulation of ARF protein signal transduction; IEA:InterPro.
DR CDD; cd01252; PH_GRP1-like; 1.
DR CDD; cd00171; Sec7; 1.
DR Gene3D; 1.10.220.20; -; 1.
DR Gene3D; 1.10.1000.11; Arf Nucleotide-binding Site Opener,domain 2; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR001849; PH_domain.
DR InterPro; IPR023394; Sec7_C_sf.
DR InterPro; IPR000904; Sec7_dom.
DR InterPro; IPR035999; Sec7_dom_sf.
DR PANTHER; PTHR10663:SF343; CYTOHESIN-2; 1.
DR PANTHER; PTHR10663; GUANYL-NUCLEOTIDE EXCHANGE FACTOR; 1.
DR Pfam; PF00169; PH; 1.
DR Pfam; PF01369; Sec7; 1.
DR SMART; SM00233; PH; 1.
DR SMART; SM00222; Sec7; 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR SUPFAM; SSF48425; Sec7 domain; 1.
DR PROSITE; PS50003; PH_DOMAIN; 1.
DR PROSITE; PS50190; SEC7; 1.
PE 4: Predicted;
KW Cell projection {ECO:0000256|ARBA:ARBA00023273};
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Reference proteome {ECO:0000313|Proteomes:UP000002281}.
FT DOMAIN 76..263
FT /note="SEC7"
FT /evidence="ECO:0000259|PROSITE:PS50190"
FT DOMAIN 281..397
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT REGION 1..37
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 41..75
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 421 AA; 48675 MW; 57F0D3A646F783A4 CRC64;
MDPGVRTPRP PAASPAMEAE NRGLSPPPKP PDLTPEERME LENIRRRKQE LLVEIQRLRE
ELSEAMSEVE GLEANEGSKT LQRNRKMAMG RKKFNMDPKK GIQFLVENEL LQNTPEEIAR
FLYKGEGLNK TAIGDYLGER EELNLAVLHA FVDLHEFTDL NLVQALRQFL WSFRLPGEAQ
KIDRMMEAFA QRYCLCNPGV FQSTDTCYVL SFAVIMLNTS LHNPNVRDKP GLERFVAMNR
GINEGGDLPE ELLRNLYDSI RNEPFKIPED DGNDLTHTFF NPDREGWLLK LGGRVKTWKR
RWFILTDNCL YYFEYTTDKE PRGIIPLENL SIREVDDPRK PNCFELYIPN NKGQLIKACK
TEADGRVVEG NHMVYRISAP TQEEKDEWIK SIQAAVSVDP FYEMLAARKK RISVKKKQEQ
P
//
