ID A0A3Q2HLU8_HORSE Unreviewed; 361 AA.
AC A0A3Q2HLU8;
DT 10-APR-2019, integrated into UniProtKB/TrEMBL.
DT 10-APR-2019, sequence version 1.
DT 27-MAR-2024, entry version 22.
DE RecName: Full=Ubiquitin carboxyl-terminal hydrolase 46 {ECO:0000256|ARBA:ARBA00039415};
DE EC=3.4.19.12 {ECO:0000256|ARBA:ARBA00012759};
DE AltName: Full=Deubiquitinating enzyme 46 {ECO:0000256|ARBA:ARBA00042431};
DE AltName: Full=Ubiquitin thioesterase 46 {ECO:0000256|ARBA:ARBA00041292};
DE AltName: Full=Ubiquitin-specific-processing protease 46 {ECO:0000256|ARBA:ARBA00042999};
GN Name=USP46 {ECO:0000313|Ensembl:ENSECAP00000035676.1,
GN ECO:0000313|VGNC:VGNC:51344};
OS Equus caballus (Horse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Perissodactyla; Equidae; Equus.
OX NCBI_TaxID=9796 {ECO:0000313|Ensembl:ENSECAP00000035676.1, ECO:0000313|Proteomes:UP000002281};
RN [1] {ECO:0000313|Ensembl:ENSECAP00000035676.1, ECO:0000313|Proteomes:UP000002281}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Thoroughbred {ECO:0000313|Ensembl:ENSECAP00000035676.1,
RC ECO:0000313|Proteomes:UP000002281};
RX PubMed=19892987; DOI=10.1126/science.1178158;
RG Broad Institute Genome Sequencing Platform;
RG Broad Institute Whole Genome Assembly Team;
RA Wade C.M., Giulotto E., Sigurdsson S., Zoli M., Gnerre S., Imsland F.,
RA Lear T.L., Adelson D.L., Bailey E., Bellone R.R., Bloecker H., Distl O.,
RA Edgar R.C., Garber M., Leeb T., Mauceli E., MacLeod J.N., Penedo M.C.T.,
RA Raison J.M., Sharpe T., Vogel J., Andersson L., Antczak D.F., Biagi T.,
RA Binns M.M., Chowdhary B.P., Coleman S.J., Della Valle G., Fryc S.,
RA Guerin G., Hasegawa T., Hill E.W., Jurka J., Kiialainen A., Lindgren G.,
RA Liu J., Magnani E., Mickelson J.R., Murray J., Nergadze S.G., Onofrio R.,
RA Pedroni S., Piras M.F., Raudsepp T., Rocchi M., Roeed K.H., Ryder O.A.,
RA Searle S., Skow L., Swinburne J.E., Syvaenen A.C., Tozaki T., Valberg S.J.,
RA Vaudin M., White J.R., Zody M.C., Lander E.S., Lindblad-Toh K.;
RT "Genome sequence, comparative analysis, and population genetics of the
RT domestic horse.";
RL Science 326:865-867(2009).
RN [2] {ECO:0000313|Ensembl:ENSECAP00000035676.1}
RP IDENTIFICATION.
RC STRAIN=Thoroughbred {ECO:0000313|Ensembl:ENSECAP00000035676.1};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=Thiol-dependent hydrolysis of ester, thioester, amide, peptide
CC and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-
CC residue protein attached to proteins as an intracellular targeting
CC signal).; EC=3.4.19.12; Evidence={ECO:0000256|ARBA:ARBA00000707};
CC -!- SIMILARITY: Belongs to the peptidase C19 family. USP12/USP46 subfamily.
CC {ECO:0000256|ARBA:ARBA00038282}.
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DR AlphaFoldDB; A0A3Q2HLU8; -.
DR Ensembl; ENSECAT00000039299.3; ENSECAP00000035676.1; ENSECAG00000009006.4.
DR VGNC; VGNC:51344; USP46.
DR GeneTree; ENSGT00940000153284; -.
DR Proteomes; UP000002281; Chromosome 3.
DR Bgee; ENSECAG00000009006; Expressed in prefrontal cortex and 23 other cell types or tissues.
DR GO; GO:0004843; F:cysteine-type deubiquitinase activity; IEA:InterPro.
DR GO; GO:0007610; P:behavior; IEA:UniProtKB-KW.
DR CDD; cd02663; Peptidase_C19G; 1.
DR Gene3D; 3.90.70.10; Cysteine proteinases; 1.
DR InterPro; IPR038765; Papain-like_cys_pep_sf.
DR InterPro; IPR001394; Peptidase_C19_UCH.
DR InterPro; IPR018200; USP_CS.
DR InterPro; IPR028889; USP_dom.
DR PANTHER; PTHR24006; UBIQUITIN CARBOXYL-TERMINAL HYDROLASE; 1.
DR PANTHER; PTHR24006:SF714; UBIQUITIN CARBOXYL-TERMINAL HYDROLASE 46; 1.
DR Pfam; PF00443; UCH; 1.
DR SUPFAM; SSF54001; Cysteine proteinases; 1.
DR PROSITE; PS00972; USP_1; 1.
DR PROSITE; PS00973; USP_2; 1.
DR PROSITE; PS50235; USP_3; 1.
PE 3: Inferred from homology;
KW Behavior {ECO:0000256|ARBA:ARBA00022610};
KW Reference proteome {ECO:0000313|Proteomes:UP000002281}.
FT DOMAIN 30..360
FT /note="USP"
FT /evidence="ECO:0000259|PROSITE:PS50235"
SQ SEQUENCE 361 AA; 41838 MW; FB274ECA2F76CBB8 CRC64;
GELLVTIGTN ASALEKDIGP EQFPINEHYF GLVNFGNTCY CNSVLQALYF CRPFRENVLA
YKAQQKKKEN LLTCLADLFH SIATQKKKVG VIPPKKFISR LRKENDLFDN YMQQDAHEFL
NYLLNTIADI LQEEKKQEKQ NGKLKNGNMN ETAENNKPEL TWVHEIFQGT LTNETRCLNC
ETVSSKDEDF LDLSVDVEQN TSITHCLRDF SNTETLCSEQ KYYCETCCSK QEAQKRMRVK
KLPMILALHL KRFKYMEQLH RYTKLSYRVV FPLELRLFNT SSDAVNLDRM YDLVAVVVHC
GSGPNRGHYI TIVKSHGFWL LFDDDIVEKI DAQAIEEFYG LTSDISKNSE SGYILFYQSR
E
//
