ID A0A3Q2HMX7_HORSE Unreviewed; 1522 AA.
AC A0A3Q2HMX7;
DT 10-APR-2019, integrated into UniProtKB/TrEMBL.
DT 13-SEP-2023, sequence version 2.
DT 27-MAR-2024, entry version 24.
DE SubName: Full=ERCC excision repair 6 like 2 {ECO:0000313|Ensembl:ENSECAP00000034585.2};
GN Name=ERCC6L2 {ECO:0000313|Ensembl:ENSECAP00000034585.2,
GN ECO:0000313|VGNC:VGNC:101470};
OS Equus caballus (Horse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Perissodactyla; Equidae; Equus.
OX NCBI_TaxID=9796 {ECO:0000313|Ensembl:ENSECAP00000034585.2, ECO:0000313|Proteomes:UP000002281};
RN [1] {ECO:0000313|Ensembl:ENSECAP00000034585.2, ECO:0000313|Proteomes:UP000002281}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Thoroughbred {ECO:0000313|Ensembl:ENSECAP00000034585.2,
RC ECO:0000313|Proteomes:UP000002281};
RX PubMed=19892987; DOI=10.1126/science.1178158;
RG Broad Institute Genome Sequencing Platform;
RG Broad Institute Whole Genome Assembly Team;
RA Wade C.M., Giulotto E., Sigurdsson S., Zoli M., Gnerre S., Imsland F.,
RA Lear T.L., Adelson D.L., Bailey E., Bellone R.R., Bloecker H., Distl O.,
RA Edgar R.C., Garber M., Leeb T., Mauceli E., MacLeod J.N., Penedo M.C.T.,
RA Raison J.M., Sharpe T., Vogel J., Andersson L., Antczak D.F., Biagi T.,
RA Binns M.M., Chowdhary B.P., Coleman S.J., Della Valle G., Fryc S.,
RA Guerin G., Hasegawa T., Hill E.W., Jurka J., Kiialainen A., Lindgren G.,
RA Liu J., Magnani E., Mickelson J.R., Murray J., Nergadze S.G., Onofrio R.,
RA Pedroni S., Piras M.F., Raudsepp T., Rocchi M., Roeed K.H., Ryder O.A.,
RA Searle S., Skow L., Swinburne J.E., Syvaenen A.C., Tozaki T., Valberg S.J.,
RA Vaudin M., White J.R., Zody M.C., Lander E.S., Lindblad-Toh K.;
RT "Genome sequence, comparative analysis, and population genetics of the
RT domestic horse.";
RL Science 326:865-867(2009).
RN [2] {ECO:0000313|Ensembl:ENSECAP00000034585.2}
RP IDENTIFICATION.
RC STRAIN=Thoroughbred {ECO:0000313|Ensembl:ENSECAP00000034585.2};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the SNF2/RAD54 helicase family.
CC {ECO:0000256|ARBA:ARBA00007025}.
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DR Ensembl; ENSECAT00000052379.3; ENSECAP00000034585.2; ENSECAG00000007770.4.
DR VGNC; VGNC:101470; ERCC6L2.
DR GeneTree; ENSGT00940000163752; -.
DR OMA; PDSEPCH; -.
DR Proteomes; UP000002281; Chromosome 23.
DR Bgee; ENSECAG00000007770; Expressed in brainstem and 23 other cell types or tissues.
DR ExpressionAtlas; A0A3Q2HMX7; baseline.
DR GO; GO:0005634; C:nucleus; IEA:UniProt.
DR GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR GO; GO:0140658; F:ATP-dependent chromatin remodeler activity; IEA:InterPro.
DR GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR CDD; cd18005; DEXHc_ERCC6L2; 1.
DR CDD; cd18793; SF2_C_SNF; 1.
DR CDD; cd20400; Tudor_ERCC6L2; 1.
DR Gene3D; 2.30.30.140; -; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR Gene3D; 3.40.50.10810; Tandem AAA-ATPase domain; 1.
DR InterPro; IPR002464; DNA/RNA_helicase_DEAH_CS.
DR InterPro; IPR014001; Helicase_ATP-bd.
DR InterPro; IPR001650; Helicase_C.
DR InterPro; IPR029256; Heliccase-ass-bd.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR038718; SNF2-like_sf.
DR InterPro; IPR049730; SNF2/RAD54-like_C.
DR InterPro; IPR000330; SNF2_N.
DR PANTHER; PTHR45629:SF7; DNA EXCISION REPAIR PROTEIN ERCC-6-RELATED; 1.
DR PANTHER; PTHR45629; SNF2/RAD54 FAMILY MEMBER; 1.
DR Pfam; PF00271; Helicase_C; 1.
DR Pfam; PF00176; SNF2-rel_dom; 1.
DR Pfam; PF14773; VIGSSK; 1.
DR SMART; SM00487; DEXDc; 1.
DR SMART; SM00490; HELICc; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 2.
DR PROSITE; PS00690; DEAH_ATP_HELICASE; 1.
DR PROSITE; PS51192; HELICASE_ATP_BIND_1; 1.
DR PROSITE; PS51194; HELICASE_CTER; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Helicase {ECO:0000256|ARBA:ARBA00022806};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000002281}.
FT DOMAIN 135..321
FT /note="Helicase ATP-binding"
FT /evidence="ECO:0000259|PROSITE:PS51192"
FT DOMAIN 512..662
FT /note="Helicase C-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51194"
FT REGION 1..22
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 738..757
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 779..803
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 892..916
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 947..975
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1263..1294
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1324..1359
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1371..1393
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 897..916
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 948..968
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1263..1286
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1330..1359
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1522 AA; 172902 MW; CD63E2972D12C03C CRC64;
MDPSAPKARA EAAGKDMWHP GERCLAPSPD NEKLCEASIK SVTVDENGKS FAVVLYSDFQ
ERKVPLKRLQ EVKSVKDCPR SFIFDDEDLE KPYFPDRKFP SSSVAFQLSE DGDSIPYTIN
RYLRDYQREG AQFLYGHFIQ GRGCILGDDM GLGKTVQVIS FLAAVLHKKG TREDIENNMP
EFLLRSMKKE PSSSTAKKMF LIVAPLSVLY NWKDELDTWG YFRVTILHGN KKDNELIRVK
QRKCEIALTT YETLRLCLDE LNSLEWSAVI VDEAHRIKNP KARVTEVMKA LKCNVRIGLT
GTILQNNMKE LWCVMDWAVP GLLGSRINFK KQFSDPVEHG QRHTATKREL ATGRKAMRRL
AKKMSGWFLR RTKVLIKDQL PKKEDRMVYC SLTDFQKAVY QTVLETEDVT LILQSSEPCT
CSSGRKRRNC CYKTNSHGET VKTLYFSYLA VLQKVANHVA LLQAASASKQ QETLIKRICD
QVFSKFPDFV QKSKDAAFET LSDPKYSGKM KVLQQLLNHC RKNKDKVLLF SFSTKLLDVL
QQYCMASGLD YRRLDGNTKS EDRIKIVKEF NSTQDVNICL VSTMAGGLGL NFVGANVVVL
FDPTWNPAND LQAIDRAYRI GQCRDVKVLR LISLGTVEEI MYLRQVYKQQ LHCVVVGSEN
AKRYFEAVQG SKEHQGELFG VYNLFKLRSH ESCLTRDILE PREPDCQEHR GLEQPADPLA
KEACDLCSDF SDEEAVGNSK LKTAKNKPRD SSKSGSPAQL TLLQCGFSNV FETTSKAVED
GDGNIASDDE SSDEQPTCLS TEAKDVDCHK SRDSIGISRY RKLANTLNPN EKCIFDKSEK
ILEQKISSEF DDEKNFKNTT DHHCILQNVT ESEDSDVVFP TQYTTQKVPK NSIRFKPPVD
GSEDSETENP VKIKNNGDYK KTDFRVNGLI SKQLNLENLT LKPIMKRKGS SDISDESDDI
EISSKSKVRK QRATTSLRFK RKKEKKRELY TFPKTVKKTN QLYATDGDCN SQTVDDFSSS
DDDLSVSDIT FSKQSHRPET MKDRISFSSK LPSHKKNSTF IPRKPMKFSN ERVVNQAQMY
ESMDKFLDGV REVAYIHSNQ NVIGSSRAEN HMSRWAARDV FELKQFSQLP ANIAVCTSKT
SKEKMKADTL THTKKSQQPG EGGISLPLYI SHPVSQKKKG VYRTDQTTFI IGETPKGVRR
KQFEEMACYF NLSSVKEFAK HITNATSEER QKMLRDFYAS QYPEVKEFFA DSASEFIKSA
YEEGERVRNK SEKRESLIEE RLSDSETSSF QDSTKNYSQI CRPKIYTGKS IKFQNHGSCR
EEVLSDDAET KKSPISSTQD PNNGKNSHTS KNTVPSCSLN RKSEAYESKL ENTVKDQQDL
TRTGISRNGP LFKEENKKIE NSMLGNTSVV GLLGDTSILD DLFKSHGNSP TRLPKKVLSG
PMEKAKQRPK DFWDILNEQN DDSLSKLTDL AVIETLCEKV PPAASSKRKE QLETSLWKSN
ENFLWKIINS NDTDENTTNT QE
//
