ID A0A3Q2HN35_HORSE Unreviewed; 1308 AA.
AC A0A3Q2HN35;
DT 10-APR-2019, integrated into UniProtKB/TrEMBL.
DT 13-SEP-2023, sequence version 3.
DT 27-MAR-2024, entry version 19.
DE SubName: Full=Cordon-bleu WH2 repeat protein {ECO:0000313|Ensembl:ENSECAP00000036189.3};
GN Name=COBL {ECO:0000313|Ensembl:ENSECAP00000036189.3};
OS Equus caballus (Horse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Perissodactyla; Equidae; Equus.
OX NCBI_TaxID=9796 {ECO:0000313|Ensembl:ENSECAP00000036189.3, ECO:0000313|Proteomes:UP000002281};
RN [1] {ECO:0000313|Ensembl:ENSECAP00000036189.3, ECO:0000313|Proteomes:UP000002281}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Thoroughbred {ECO:0000313|Ensembl:ENSECAP00000036189.3,
RC ECO:0000313|Proteomes:UP000002281};
RX PubMed=19892987; DOI=10.1126/science.1178158;
RG Broad Institute Genome Sequencing Platform;
RG Broad Institute Whole Genome Assembly Team;
RA Wade C.M., Giulotto E., Sigurdsson S., Zoli M., Gnerre S., Imsland F.,
RA Lear T.L., Adelson D.L., Bailey E., Bellone R.R., Bloecker H., Distl O.,
RA Edgar R.C., Garber M., Leeb T., Mauceli E., MacLeod J.N., Penedo M.C.T.,
RA Raison J.M., Sharpe T., Vogel J., Andersson L., Antczak D.F., Biagi T.,
RA Binns M.M., Chowdhary B.P., Coleman S.J., Della Valle G., Fryc S.,
RA Guerin G., Hasegawa T., Hill E.W., Jurka J., Kiialainen A., Lindgren G.,
RA Liu J., Magnani E., Mickelson J.R., Murray J., Nergadze S.G., Onofrio R.,
RA Pedroni S., Piras M.F., Raudsepp T., Rocchi M., Roeed K.H., Ryder O.A.,
RA Searle S., Skow L., Swinburne J.E., Syvaenen A.C., Tozaki T., Valberg S.J.,
RA Vaudin M., White J.R., Zody M.C., Lander E.S., Lindblad-Toh K.;
RT "Genome sequence, comparative analysis, and population genetics of the
RT domestic horse.";
RL Science 326:865-867(2009).
RN [2] {ECO:0000313|Ensembl:ENSECAP00000036189.3}
RP IDENTIFICATION.
RC STRAIN=Thoroughbred {ECO:0000313|Ensembl:ENSECAP00000036189.3};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR Ensembl; ENSECAT00000062598.3; ENSECAP00000036189.3; ENSECAG00000021645.4.
DR GeneTree; ENSGT00530000063608; -.
DR Proteomes; UP000002281; Chromosome 4.
DR Bgee; ENSECAG00000021645; Expressed in muscle tissue and 21 other cell types or tissues.
DR ExpressionAtlas; A0A3Q2HN35; baseline.
DR GO; GO:0003785; F:actin monomer binding; IEA:InterPro.
DR CDD; cd21799; WH2_Wa_Cobl; 1.
DR CDD; cd21800; WH2_Wb_Cobl; 1.
DR CDD; cd21801; WH2_Wc_Cobl; 1.
DR InterPro; IPR039895; COBL-like.
DR InterPro; IPR019025; Cordon-bleu_ubiquitin_domain.
DR InterPro; IPR003124; WH2_dom.
DR PANTHER; PTHR47008; PROTEIN CORDON-BLEU; 1.
DR PANTHER; PTHR47008:SF1; PROTEIN CORDON-BLEU; 1.
DR Pfam; PF09469; Cobl; 1.
DR Pfam; PF02205; WH2; 3.
DR SMART; SM00246; WH2; 3.
DR PROSITE; PS51082; WH2; 3.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000002281}.
FT DOMAIN 1158..1178
FT /note="WH2"
FT /evidence="ECO:0000259|PROSITE:PS51082"
FT DOMAIN 1198..1218
FT /note="WH2"
FT /evidence="ECO:0000259|PROSITE:PS51082"
FT DOMAIN 1284..1304
FT /note="WH2"
FT /evidence="ECO:0000259|PROSITE:PS51082"
FT REGION 1..36
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 258..484
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 496..540
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 642..744
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 833..897
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 943..1199
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1240..1282
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 258..292
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 337..353
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 379..404
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 448..480
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 513..540
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 653..667
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 677..692
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 698..717
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 944..960
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 961..984
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1023..1062
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1110..1124
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1170..1184
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1246..1263
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1264..1281
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1308 AA; 141310 MW; 318D8DEE859A7189 CRC64;
MKARAPPPPG KPATPDVQSR QKPRRDVSPG PPQNLLTMKE NLRNSVVDVT VVLPSGLEKK
SVVNGSHAMM DLLVELCLQN HLNPSHHALE IRSSETQQPL SFKPNTLVGT LNVHTVFLKE
KVPEEKVKPG PPKVPEKSVR LVVNYLRTQK AIVRVSPEVP LQNILPVICA KCEVSPEHVV
LLRDNIAGEE LELSKSLNEL GIKELYAWDN KRVLLTKTQS EPSLSCRETF RKSSLGNDET
DKEKKKILGF FKVNKRSNSK GCLTTPNSPS VNSRSMTLGP SFSLSNISGV SVKSDMKKRR
APPPPSLPGA GPPARDKASE KVSLGSQIDL QKKKRRAPAP PPPQPPPPSP LVPTRTEDKE
ENRKSTTGVG RQVPQKPPRG SARGPPQLVL PPPPPYPPPD TDVAEPLSFP EEGAVSEASD
LRPTLSLPLG PDSPCDTDGV PPVLSEAEET VSVSSCFASE DTTEDSGVMS SPSDIISLDS
QHDSTKFKDK WTIDQEDCSD QDLAGTPELG PQKNPSWERN VSGNWQPRTE KAATTSNDDE
DQFIARQFQQ TLTELDDDLE EMEESYETDT SSLTSSINGV SSGCMQDAII PDSDENAIPV
TFIGEVLDDP VDSGLFSNRN NNAGSFDKGS INNGRAHLMP YQAEHSQQHG KKNAEVPESS
TPSQDIGKEI KSAWPNTCKD VNPNNVEPKA TSASRLPTHD LHTKERGEAH GSAHSEETQA
IKRVNSQPMK EKKGNDKNDV SAPPFWYQRG QNARGSYGPK YGLTTYKIVP PKSEMRCYDR
GVSLSTGAIK IDELGNLVNP HANGGRIILL SPTLETEGEP IGKVKEFWRA NSMGKHSGRP
TECSAKRTPT VPAKPQHQES KLRAEPTFPD PKVTLPQQQS AHQEGGRHLE EGKSQPPSAV
ACHMKVPVAN TTEVPFLKPQ RRTSSQYVAS AIAKQIGTPK THTNIVRKHA DAEKTHEGRA
QELTGQSSAV KGGTTPSPCS EKQICNDGAE SAEGAHPRGQ VSSPYGKVSN QDCPADIHRR
SYVPLVTTSQ RDHVSVGQNC GSSGKQSTSN HRTGSASDLK FPPDSTNPLP PGSGDDETPG
RALVNGSRRV PVHSEPHSPR MPGTNSHTGR EPLEQKEKPN LLCTDVHETD GTLPPSIFGP
KKKFRPVVQR PAPKDTSLHS ALMEAIHSAG GKDGLRKTAE HSSEGGPKKP SYTEAESERS
ALLAAIRGHS GACSLRKVTS LASEELQSFR HAALSAQMSE PPGLEDLRVQ PPPALPPPPP
LAASSTSRMA SRSSSGPLNN PVDARQALMD AIRSGTGAAR LRKVPLLV
//
