ID A0A3Q2HPH8_HORSE Unreviewed; 770 AA.
AC A0A3Q2HPH8;
DT 10-APR-2019, integrated into UniProtKB/TrEMBL.
DT 10-APR-2019, sequence version 1.
DT 27-MAR-2024, entry version 20.
DE SubName: Full=Solute carrier family 22 member 3 {ECO:0000313|Ensembl:ENSECAP00000036935.1};
GN Name=SLC22A3 {ECO:0000313|VGNC:VGNC:23076};
OS Equus caballus (Horse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Perissodactyla; Equidae; Equus.
OX NCBI_TaxID=9796 {ECO:0000313|Ensembl:ENSECAP00000036935.1, ECO:0000313|Proteomes:UP000002281};
RN [1] {ECO:0000313|Ensembl:ENSECAP00000036935.1, ECO:0000313|Proteomes:UP000002281}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Thoroughbred {ECO:0000313|Ensembl:ENSECAP00000036935.1,
RC ECO:0000313|Proteomes:UP000002281};
RX PubMed=19892987; DOI=10.1126/science.1178158;
RG Broad Institute Genome Sequencing Platform;
RG Broad Institute Whole Genome Assembly Team;
RA Wade C.M., Giulotto E., Sigurdsson S., Zoli M., Gnerre S., Imsland F.,
RA Lear T.L., Adelson D.L., Bailey E., Bellone R.R., Bloecker H., Distl O.,
RA Edgar R.C., Garber M., Leeb T., Mauceli E., MacLeod J.N., Penedo M.C.T.,
RA Raison J.M., Sharpe T., Vogel J., Andersson L., Antczak D.F., Biagi T.,
RA Binns M.M., Chowdhary B.P., Coleman S.J., Della Valle G., Fryc S.,
RA Guerin G., Hasegawa T., Hill E.W., Jurka J., Kiialainen A., Lindgren G.,
RA Liu J., Magnani E., Mickelson J.R., Murray J., Nergadze S.G., Onofrio R.,
RA Pedroni S., Piras M.F., Raudsepp T., Rocchi M., Roeed K.H., Ryder O.A.,
RA Searle S., Skow L., Swinburne J.E., Syvaenen A.C., Tozaki T., Valberg S.J.,
RA Vaudin M., White J.R., Zody M.C., Lander E.S., Lindblad-Toh K.;
RT "Genome sequence, comparative analysis, and population genetics of the
RT domestic horse.";
RL Science 326:865-867(2009).
RN [2] {ECO:0000313|Ensembl:ENSECAP00000036935.1}
RP IDENTIFICATION.
RC STRAIN=Thoroughbred {ECO:0000313|Ensembl:ENSECAP00000036935.1};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Basolateral cell membrane
CC {ECO:0000256|ARBA:ARBA00004554}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004554}. Lateral cell membrane
CC {ECO:0000256|ARBA:ARBA00034693}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00034693}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the major facilitator (TC 2.A.1) superfamily.
CC Organic cation transporter (TC 2.A.1.19) family.
CC {ECO:0000256|ARBA:ARBA00009203}.
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DR AlphaFoldDB; A0A3Q2HPH8; -.
DR Ensembl; ENSECAT00000059394.2; ENSECAP00000036935.1; ENSECAG00000004372.4.
DR VGNC; VGNC:23076; SLC22A3.
DR GeneTree; ENSGT00940000160810; -.
DR Proteomes; UP000002281; Chromosome 31.
DR Bgee; ENSECAG00000004372; Expressed in endometrium and 16 other cell types or tissues.
DR ExpressionAtlas; A0A3Q2HPH8; baseline.
DR GO; GO:0016324; C:apical plasma membrane; IEA:Ensembl.
DR GO; GO:0016323; C:basolateral plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0012505; C:endomembrane system; IEA:Ensembl.
DR GO; GO:0016328; C:lateral plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0031966; C:mitochondrial membrane; IEA:Ensembl.
DR GO; GO:0043025; C:neuronal cell body; IEA:Ensembl.
DR GO; GO:0098793; C:presynapse; IEA:GOC.
DR GO; GO:0008504; F:monoamine transmembrane transporter activity; IEA:Ensembl.
DR GO; GO:0005326; F:neurotransmitter transmembrane transporter activity; IEA:Ensembl.
DR GO; GO:0015651; F:quaternary ammonium group transmembrane transporter activity; IEA:Ensembl.
DR GO; GO:0019534; F:toxin transmembrane transporter activity; IEA:Ensembl.
DR GO; GO:0090494; P:dopamine uptake; IEA:Ensembl.
DR GO; GO:0051625; P:epinephrine uptake; IEA:Ensembl.
DR GO; GO:0051615; P:histamine uptake; IEA:Ensembl.
DR GO; GO:0006811; P:monoatomic ion transport; IEA:UniProtKB-KW.
DR GO; GO:0015718; P:monocarboxylic acid transport; IEA:Ensembl.
DR GO; GO:0051620; P:norepinephrine uptake; IEA:Ensembl.
DR GO; GO:0032098; P:regulation of appetite; IEA:Ensembl.
DR GO; GO:0051610; P:serotonin uptake; IEA:Ensembl.
DR GO; GO:0042908; P:xenobiotic transport; IEA:Ensembl.
DR CDD; cd17379; MFS_SLC22A1_2_3; 1.
DR Gene3D; 1.20.1250.20; MFS general substrate transporter like domains; 1.
DR InterPro; IPR011701; MFS.
DR InterPro; IPR020846; MFS_dom.
DR InterPro; IPR036259; MFS_trans_sf.
DR InterPro; IPR004749; Orgcat_transp/SVOP.
DR InterPro; IPR005829; Sugar_transporter_CS.
DR NCBIfam; TIGR00898; 2A0119; 1.
DR PANTHER; PTHR24064; SOLUTE CARRIER FAMILY 22 MEMBER; 1.
DR PANTHER; PTHR24064:SF52; SOLUTE CARRIER FAMILY 22 MEMBER 3; 1.
DR Pfam; PF07690; MFS_1; 1.
DR SUPFAM; SSF103473; MFS general substrate transporter; 1.
DR PROSITE; PS50850; MFS; 1.
DR PROSITE; PS00216; SUGAR_TRANSPORT_1; 1.
PE 3: Inferred from homology;
KW Ion transport {ECO:0000256|ARBA:ARBA00023065};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000002281};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00023065}.
FT TRANSMEM 219..240
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 367..384
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 391..411
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 417..438
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 450..472
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 478..496
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 560..582
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 588..609
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 616..635
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 641..664
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 676..700
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 706..725
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 306..730
FT /note="Major facilitator superfamily (MFS) profile"
FT /evidence="ECO:0000259|PROSITE:PS50850"
FT REGION 18..60
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 77..194
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 747..770
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 770 AA; 83033 MW; 273E18FD97F655C2 CRC64;
MGQGQRQAWF EDLTARAQGC ADQARHTEGL RTGGGLRGLR DSGETKSEEP REHLGGPGTF
CFWSAPRGRQ QSRLLAGTEW SSAPGRRLCR HSQSPPGPRR AVALRQAAPP RPSRAPTSTP
RRRPRGAGTA AAGAPGRVAG ASAPGTGGAA AAGAAPGGVG RVRRGGGGWR RRRRARGSLG
GPGGGRQDAL GEPAGARTMP SFDEALQRAG EFGRFQRRVF LLLCLTGVTF AFLFVGVVFL
GSRPDHYWCR GPSAAALAER CGWSPEEEWN RTAPALLGPA PPDRRGDGRC QRYLLEEANA
TVPAAAAAAA AAAGALSCTD PLAAFPNRSA PLVPCRGGWR YAQAHSTIVS EFDLVCVNAW
MLDLTQAILN LGFLTGAFTL GYAADRYGRI VVYLISCFGV GITGVVVAFA PNFPVFVVFR
FLQGVFGKGT WITCYVIVTE IVGSKQRRIV GIVIQMFFTL GIIILPGIAY FIPNWQGIQL
AITLPNFLFL LYYWVVPESP RWLITRKKGD KALKILRSIA KCNGKYLSPS YSEITVTDEE
VSNPSFLDLV RTPQMRKCTL ILMFAWFTSA VVYQGLVMRL GIIGGNLYID FFISGVVELP
GALLILLTIE RLGRRLPFAA SNIVAGVACL VTAFLPEGIP WLRTTVATLG RLGITIAFEI
VYLVNSELYP TTLRNFGVSL CSGLCDFGGI IAPFLLFRLA AVWLELPLII FGILASVCGA
LVMLLPETKG IALPETVDDV EKLGSPRSYK CGRRKKTQVS RSHHEAPSQR
//
