ID A0A3Q2HR23_HORSE Unreviewed; 440 AA.
AC A0A3Q2HR23;
DT 10-APR-2019, integrated into UniProtKB/TrEMBL.
DT 10-APR-2019, sequence version 1.
DT 27-MAR-2024, entry version 18.
DE SubName: Full=Phosphoinositide-3-kinase regulatory subunit 3 {ECO:0000313|Ensembl:ENSECAP00000037439.1};
GN Name=PIK3R3 {ECO:0000313|Ensembl:ENSECAP00000037439.1};
OS Equus caballus (Horse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Perissodactyla; Equidae; Equus.
OX NCBI_TaxID=9796 {ECO:0000313|Ensembl:ENSECAP00000037439.1, ECO:0000313|Proteomes:UP000002281};
RN [1] {ECO:0000313|Ensembl:ENSECAP00000037439.1, ECO:0000313|Proteomes:UP000002281}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Thoroughbred {ECO:0000313|Ensembl:ENSECAP00000037439.1,
RC ECO:0000313|Proteomes:UP000002281};
RX PubMed=19892987; DOI=10.1126/science.1178158;
RG Broad Institute Genome Sequencing Platform;
RG Broad Institute Whole Genome Assembly Team;
RA Wade C.M., Giulotto E., Sigurdsson S., Zoli M., Gnerre S., Imsland F.,
RA Lear T.L., Adelson D.L., Bailey E., Bellone R.R., Bloecker H., Distl O.,
RA Edgar R.C., Garber M., Leeb T., Mauceli E., MacLeod J.N., Penedo M.C.T.,
RA Raison J.M., Sharpe T., Vogel J., Andersson L., Antczak D.F., Biagi T.,
RA Binns M.M., Chowdhary B.P., Coleman S.J., Della Valle G., Fryc S.,
RA Guerin G., Hasegawa T., Hill E.W., Jurka J., Kiialainen A., Lindgren G.,
RA Liu J., Magnani E., Mickelson J.R., Murray J., Nergadze S.G., Onofrio R.,
RA Pedroni S., Piras M.F., Raudsepp T., Rocchi M., Roeed K.H., Ryder O.A.,
RA Searle S., Skow L., Swinburne J.E., Syvaenen A.C., Tozaki T., Valberg S.J.,
RA Vaudin M., White J.R., Zody M.C., Lander E.S., Lindblad-Toh K.;
RT "Genome sequence, comparative analysis, and population genetics of the
RT domestic horse.";
RL Science 326:865-867(2009).
RN [2] {ECO:0000313|Ensembl:ENSECAP00000037439.1}
RP IDENTIFICATION.
RC STRAIN=Thoroughbred {ECO:0000313|Ensembl:ENSECAP00000037439.1};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the PI3K p85 subunit family.
CC {ECO:0000256|ARBA:ARBA00009442}.
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DR AlphaFoldDB; A0A3Q2HR23; -.
DR Ensembl; ENSECAT00000055170.2; ENSECAP00000037439.1; ENSECAG00000033344.3.
DR GeneTree; ENSGT00940000156259; -.
DR Proteomes; UP000002281; Chromosome 2.
DR Bgee; ENSECAG00000033344; Expressed in cerebellum and 23 other cell types or tissues.
DR ExpressionAtlas; A0A3Q2HR23; baseline.
DR CDD; cd09930; SH2_cSH2_p85_like; 1.
DR CDD; cd09942; SH2_nSH2_p85_like; 1.
DR Gene3D; 1.10.287.1490; -; 1.
DR Gene3D; 3.30.505.10; SH2 domain; 2.
DR InterPro; IPR032498; PI3K_P85_iSH2.
DR InterPro; IPR035020; PI3kinase_P85_cSH2.
DR InterPro; IPR035022; PI3kinase_P85_nSH2.
DR InterPro; IPR000980; SH2.
DR InterPro; IPR036860; SH2_dom_sf.
DR PANTHER; PTHR10155; PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT; 1.
DR PANTHER; PTHR10155:SF10; PI3K21B, ISOFORM B; 1.
DR Pfam; PF16454; PI3K_P85_iSH2; 1.
DR Pfam; PF00017; SH2; 2.
DR PRINTS; PR00678; PI3KINASEP85.
DR PRINTS; PR00401; SH2DOMAIN.
DR SMART; SM00252; SH2; 2.
DR SUPFAM; SSF55550; SH2 domain; 2.
DR PROSITE; PS50001; SH2; 2.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Reference proteome {ECO:0000313|Proteomes:UP000002281};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW SH2 domain {ECO:0000256|ARBA:ARBA00022999, ECO:0000256|PROSITE-
KW ProRule:PRU00191}.
FT DOMAIN 44..139
FT /note="SH2"
FT /evidence="ECO:0000259|PROSITE:PS50001"
FT DOMAIN 337..431
FT /note="SH2"
FT /evidence="ECO:0000259|PROSITE:PS50001"
FT REGION 12..33
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 160..187
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 225..273
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 440 AA; 51647 MW; CAC91DC2C5FFED14 CRC64;
MTTWIDTSTV TYRQSLPPKP PKPMTSGISN GIKDSSVSLQ DAEWYWGDIS REEVNDKLRD
MPDGTFLVRD ASTKMQGDYT LTLRKGGNNK LIKIYHRDGK YGFSDPLTFN SVVELINHYH
HESLAQYNPK LDVKLTYPVS RYQQDQLVKE DNIDAVGKKL QEYHSQYQEK SKEYDRLYEE
YTRTSQEIQM KRTAIEAFNE TIKIFEEQCH TQEQHSKEYI ERFRREGNEK EIERIMMNYD
KLKSRLGEIH DSKMRLEQDL KKQALDNREI DKKMNSIKPD LIQLRKIRDQ HLVWLNHKGV
RQKRLNAWLG IKNEDADETY FINEEDESLP HYDEKTWFVE DINRVQAEDL LCGKPDGAFL
IRESSKEGCY ACSVVADGEV KHCVIYSTAR GYGFAEPYNL YSSLKELVLH YQQTSLVQHN
DSLNVRLAYP VHAQMPSLCR
//
