ID A0A3Q2HRA1_HORSE Unreviewed; 1951 AA.
AC A0A3Q2HRA1;
DT 10-APR-2019, integrated into UniProtKB/TrEMBL.
DT 13-SEP-2023, sequence version 2.
DT 27-MAR-2024, entry version 24.
DE SubName: Full=Rho GTPase activating protein 21 {ECO:0000313|Ensembl:ENSECAP00000037670.2};
GN Name=ARHGAP21 {ECO:0000313|Ensembl:ENSECAP00000037670.2,
GN ECO:0000313|VGNC:VGNC:15463};
OS Equus caballus (Horse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Perissodactyla; Equidae; Equus.
OX NCBI_TaxID=9796 {ECO:0000313|Ensembl:ENSECAP00000037670.2, ECO:0000313|Proteomes:UP000002281};
RN [1] {ECO:0000313|Ensembl:ENSECAP00000037670.2, ECO:0000313|Proteomes:UP000002281}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Thoroughbred {ECO:0000313|Ensembl:ENSECAP00000037670.2,
RC ECO:0000313|Proteomes:UP000002281};
RX PubMed=19892987; DOI=10.1126/science.1178158;
RG Broad Institute Genome Sequencing Platform;
RG Broad Institute Whole Genome Assembly Team;
RA Wade C.M., Giulotto E., Sigurdsson S., Zoli M., Gnerre S., Imsland F.,
RA Lear T.L., Adelson D.L., Bailey E., Bellone R.R., Bloecker H., Distl O.,
RA Edgar R.C., Garber M., Leeb T., Mauceli E., MacLeod J.N., Penedo M.C.T.,
RA Raison J.M., Sharpe T., Vogel J., Andersson L., Antczak D.F., Biagi T.,
RA Binns M.M., Chowdhary B.P., Coleman S.J., Della Valle G., Fryc S.,
RA Guerin G., Hasegawa T., Hill E.W., Jurka J., Kiialainen A., Lindgren G.,
RA Liu J., Magnani E., Mickelson J.R., Murray J., Nergadze S.G., Onofrio R.,
RA Pedroni S., Piras M.F., Raudsepp T., Rocchi M., Roeed K.H., Ryder O.A.,
RA Searle S., Skow L., Swinburne J.E., Syvaenen A.C., Tozaki T., Valberg S.J.,
RA Vaudin M., White J.R., Zody M.C., Lander E.S., Lindblad-Toh K.;
RT "Genome sequence, comparative analysis, and population genetics of the
RT domestic horse.";
RL Science 326:865-867(2009).
RN [2] {ECO:0000313|Ensembl:ENSECAP00000037670.2}
RP IDENTIFICATION.
RC STRAIN=Thoroughbred {ECO:0000313|Ensembl:ENSECAP00000037670.2};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cell junction {ECO:0000256|ARBA:ARBA00004282}.
CC Cytoplasm, cytoskeleton {ECO:0000256|ARBA:ARBA00004245}. Cytoplasmic
CC vesicle membrane {ECO:0000256|ARBA:ARBA00004284}; Peripheral membrane
CC protein {ECO:0000256|ARBA:ARBA00004284}. Golgi apparatus membrane
CC {ECO:0000256|ARBA:ARBA00004395}; Peripheral membrane protein
CC {ECO:0000256|ARBA:ARBA00004395}.
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DR Ensembl; ENSECAT00000052186.3; ENSECAP00000037670.2; ENSECAG00000011309.4.
DR VGNC; VGNC:15463; ARHGAP21.
DR GeneTree; ENSGT00940000155406; -.
DR Proteomes; UP000002281; Chromosome 29.
DR Bgee; ENSECAG00000011309; Expressed in brainstem and 23 other cell types or tissues.
DR ExpressionAtlas; A0A3Q2HRA1; baseline.
DR GO; GO:0070161; C:anchoring junction; IEA:UniProtKB-SubCell.
DR GO; GO:0030659; C:cytoplasmic vesicle membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005856; C:cytoskeleton; IEA:UniProtKB-SubCell.
DR GO; GO:0000139; C:Golgi membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005096; F:GTPase activator activity; IEA:UniProtKB-KW.
DR GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR CDD; cd00992; PDZ_signaling; 1.
DR CDD; cd01253; PH_ARHGAP21-like; 1.
DR CDD; cd04395; RhoGAP_ARHGAP21; 1.
DR Gene3D; 1.20.5.220; -; 1.
DR Gene3D; 2.30.42.10; -; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR Gene3D; 1.10.555.10; Rho GTPase activation protein; 1.
DR InterPro; IPR001478; PDZ.
DR InterPro; IPR041489; PDZ_6.
DR InterPro; IPR036034; PDZ_sf.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR001849; PH_domain.
DR InterPro; IPR008936; Rho_GTPase_activation_prot.
DR InterPro; IPR000198; RhoGAP_dom.
DR PANTHER; PTHR23175; PDZ DOMAIN-CONTAINING PROTEIN; 1.
DR PANTHER; PTHR23175:SF16; RHO GTPASE-ACTIVATING PROTEIN 21; 1.
DR Pfam; PF17820; PDZ_6; 1.
DR Pfam; PF00169; PH; 1.
DR Pfam; PF00620; RhoGAP; 1.
DR SMART; SM00228; PDZ; 1.
DR SMART; SM00233; PH; 1.
DR SMART; SM00324; RhoGAP; 1.
DR SUPFAM; SSF48350; GTPase activation domain, GAP; 1.
DR SUPFAM; SSF50156; PDZ domain-like; 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR PROSITE; PS50106; PDZ; 1.
DR PROSITE; PS50003; PH_DOMAIN; 1.
DR PROSITE; PS50238; RHOGAP; 1.
PE 4: Predicted;
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Cytoskeleton {ECO:0000256|ARBA:ARBA00023212};
KW Golgi apparatus {ECO:0000256|ARBA:ARBA00023034};
KW GTPase activation {ECO:0000256|ARBA:ARBA00022468};
KW Reference proteome {ECO:0000313|Proteomes:UP000002281}.
FT DOMAIN 55..164
FT /note="PDZ"
FT /evidence="ECO:0000259|PROSITE:PS50106"
FT DOMAIN 923..1032
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT DOMAIN 1140..1332
FT /note="Rho-GAP"
FT /evidence="ECO:0000259|PROSITE:PS50238"
FT REGION 1..52
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 210..233
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 302..321
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 348..377
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 432..453
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 497..518
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 663..701
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 707..726
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 849..877
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 900..919
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1079..1121
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1363..1394
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1412..1799
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1853..1951
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 214..233
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 707..724
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 849..867
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 902..919
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1088..1113
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1369..1393
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1420..1489
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1495..1557
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1565..1602
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1606..1629
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1661..1681
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1682..1725
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1748..1768
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1857..1940
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1951 AA; 216374 MW; 15B337368C9BB97A CRC64;
MMATRRTGLP EGDGDKLQDC GSPACEVSKS KDGKEQSETV SPSEDETFSW PGPKTVMLKR
TSQGFGFTLR HFIVYPPESA IQFSYKDEEN GNRGGKQRNR LEPMDTIFVK QVKEGGPAFE
AGLCTGDRII KVNGESVIGK TYSQVIALIQ NSDTTLELSV MPKDEDILQV AYSQDAYLKG
NEAYSGNARN IPEPPPLCYP WLPSAPSAMA QPVEISPPDS SSSKQQTSTP VLTQPGRAYR
MEIQVPPSPT DVAKSNTAVC VCNESVRTVI VPSEKVVDLL TSRNNHTVPS HRTEEVRYGL
SEQTSLKTVS RTTSPSSSIP TAHLIHQTTG PRSLEASGIL LKSGNYSGHS EGISSNRSQA
VDSPSASVNH YSPNSHQHID WKNYKTYKEY IDNRRLHIGC RTIQERLDSL RAASQGTADY
NQVVPNRTTL QVRRRSTSHD RVPQSVQIRQ RSVSQERLED SVLMKYCPRS ASQGALTSPS
VSFSNHRTRS WDYIEGQGES LENNSESQIP DSNGERKQTY KWSGFTEQDD RRGIYERPRQ
QEIHKSFRGS NFTVAPSIVN SDNRRMSGRG VGAQFKKIPS DLKTTQSNRN FQTTCGMSLP
RGVSQDRSPL VKVRSNSLKA PSTHVTKPSF SQNSFVSIKD QRPINHLHQN SLLNQQTWLR
TESAPDHQVE TGKPPTSSGA SVTPAPQLSE NSGTSDLELP VTQSNQDSNL QEAEIQQSNT
LDNKETVVLR EKPPSGRQTP QPLRHQSYIL AVNDQDTGSD TTCWLPNDAR REVHIKRMEE
RKASSTSPPG DSLASIPFID EPTSPSIDHD IAHIPASAVI SASASQAPSI ATVPPSLTTS
APLIRRQLSH DQESGGPASL DAQPSSKTER SKSYDEGLDD YREDAKLSFK HVSSLKGIKI
TDSQKSSEDS GSRKDSSSEV FSDAAKEGWL HFRPLVTDKG KRVGGSIRPW KQMYVVLRGH
SLYLYKDKRE QMTPSEEEQP ISVNACLIDI SYSETKRKNV FRLTTSDCEC LFQAEDRDDM
LAWIKTIQES STLNEEDTGV TNRDLISRRI KEYNSLMSSK AEQLPKTPRQ TLSIRQTLLG
AKSEPKTQSP HSPKEESERK LLSKDDTSPP KDKGTWRKGI PSIMRKTFEK KPTATGTFGV
RLDDCPPAHT NRYIPLIVDI CCKLVEERGL EYTGIYRVPG NNAAISSMQE ELNKGMADID
IQDDKWRDLN VISSLLKSFF RKLPEPLFTN EKYADFIEAN RKEDPLERLK TLKRLIHDLP
EHHYETLKFL SAHLKTVAEN SEKNKMEPRN LAIVFGPTLV RTSEDNMTHM VTHMPDQYKI
VETLIQHHDW FFTEEGAEEP LTTVQEENTV DCQPVPNIDH LLTNIGRTGV SPGDVSDSAA
SDSAKSKGSW GSGKDQYSRE LLVSSIFAAA SRKRKKPKEK AQPSSSEDEL DSVFSKKESA
EYCHSETKEE SKKESETWGR KQRIIISKEN SAKKDISATK DEKMSLPKES MPSEEPSPPH
NSKYNKSPTL SCRFTILKES PRSPGTQKSS QFEETGSDSG TLLSTSSQAS LARHSTKKST
SPETKHSEFL ANVSTITSDY STTSSTTYLT SLDSSRLSPE VQSVAESKGD EADDERSELV
SEGRPVETDS ENDFPVFPTA LTSEKLFRGK PQEVTKTSRR NSEGSEVSCT EGSLTPSLDS
RRQHFSSHKL IECDTLSRKK SARFKSDSGS LGDAKNEKDT PSITKVFDVM KKGKSTGSLL
TPTRSEPEKQ EPTWKTKIAD RLKLRPRAPA DDMFGVGNQK TSAETAKRKN IKRRHTLGGH
RDAAEISVLT FWKAQEQSGE RESELSAVNR LKPKCSAQDL SISDWLARER LRTSASDLSR
GETGDPQPGN SSTLEIAMTD PPLSFQSDAG SSPGTLASTN RPLLCTPPQS PDQINGESFQ
NVSQNASSAA NAQPHKLSET PGNKAQFRPC L
//
