ID A0A3Q2HRD7_HORSE Unreviewed; 1144 AA.
AC A0A3Q2HRD7;
DT 10-APR-2019, integrated into UniProtKB/TrEMBL.
DT 11-DEC-2019, sequence version 2.
DT 27-MAR-2024, entry version 21.
DE SubName: Full=Diaphanous related formin 3 {ECO:0000313|Ensembl:ENSECAP00000035828.2};
GN Name=DIAPH3 {ECO:0000313|Ensembl:ENSECAP00000035828.2,
GN ECO:0000313|VGNC:VGNC:17185};
OS Equus caballus (Horse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Perissodactyla; Equidae; Equus.
OX NCBI_TaxID=9796 {ECO:0000313|Ensembl:ENSECAP00000035828.2, ECO:0000313|Proteomes:UP000002281};
RN [1] {ECO:0000313|Ensembl:ENSECAP00000035828.2, ECO:0000313|Proteomes:UP000002281}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Thoroughbred {ECO:0000313|Ensembl:ENSECAP00000035828.2,
RC ECO:0000313|Proteomes:UP000002281};
RX PubMed=19892987; DOI=10.1126/science.1178158;
RG Broad Institute Genome Sequencing Platform;
RG Broad Institute Whole Genome Assembly Team;
RA Wade C.M., Giulotto E., Sigurdsson S., Zoli M., Gnerre S., Imsland F.,
RA Lear T.L., Adelson D.L., Bailey E., Bellone R.R., Bloecker H., Distl O.,
RA Edgar R.C., Garber M., Leeb T., Mauceli E., MacLeod J.N., Penedo M.C.T.,
RA Raison J.M., Sharpe T., Vogel J., Andersson L., Antczak D.F., Biagi T.,
RA Binns M.M., Chowdhary B.P., Coleman S.J., Della Valle G., Fryc S.,
RA Guerin G., Hasegawa T., Hill E.W., Jurka J., Kiialainen A., Lindgren G.,
RA Liu J., Magnani E., Mickelson J.R., Murray J., Nergadze S.G., Onofrio R.,
RA Pedroni S., Piras M.F., Raudsepp T., Rocchi M., Roeed K.H., Ryder O.A.,
RA Searle S., Skow L., Swinburne J.E., Syvaenen A.C., Tozaki T., Valberg S.J.,
RA Vaudin M., White J.R., Zody M.C., Lander E.S., Lindblad-Toh K.;
RT "Genome sequence, comparative analysis, and population genetics of the
RT domestic horse.";
RL Science 326:865-867(2009).
RN [2] {ECO:0000313|Ensembl:ENSECAP00000035828.2}
RP IDENTIFICATION.
RC STRAIN=Thoroughbred {ECO:0000313|Ensembl:ENSECAP00000035828.2};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the formin homology family. Diaphanous
CC subfamily. {ECO:0000256|ARBA:ARBA00008214}.
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DR AlphaFoldDB; A0A3Q2HRD7; -.
DR Ensembl; ENSECAT00000030119.3; ENSECAP00000035828.2; ENSECAG00000019161.4.
DR VGNC; VGNC:17185; DIAPH3.
DR GeneTree; ENSGT00940000157767; -.
DR Proteomes; UP000002281; Chromosome 17.
DR Bgee; ENSECAG00000019161; Expressed in inner cell mass and 15 other cell types or tissues.
DR GO; GO:0003779; F:actin binding; IEA:InterPro.
DR GO; GO:0031267; F:small GTPase binding; IEA:InterPro.
DR GO; GO:0030036; P:actin cytoskeleton organization; IEA:InterPro.
DR Gene3D; 1.20.58.630; -; 1.
DR Gene3D; 6.10.30.30; -; 1.
DR Gene3D; 1.20.58.2220; Formin, FH2 domain; 1.
DR Gene3D; 1.10.238.150; Formin, FH3 diaphanous domain; 1.
DR Gene3D; 1.25.10.10; Leucine-rich Repeat Variant; 1.
DR InterPro; IPR011989; ARM-like.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR014767; DAD_dom.
DR InterPro; IPR015425; FH2_Formin.
DR InterPro; IPR042201; FH2_Formin_sf.
DR InterPro; IPR010472; FH3_dom.
DR InterPro; IPR014768; GBD/FH3_dom.
DR InterPro; IPR010473; GTPase-bd.
DR PANTHER; PTHR45691; PROTEIN DIAPHANOUS; 1.
DR PANTHER; PTHR45691:SF9; PROTEIN DIAPHANOUS HOMOLOG 3; 1.
DR Pfam; PF06367; Drf_FH3; 1.
DR Pfam; PF06371; Drf_GBD; 1.
DR Pfam; PF02181; FH2; 1.
DR PRINTS; PR00049; WILMSTUMOUR.
DR SMART; SM01139; Drf_FH3; 1.
DR SMART; SM01140; Drf_GBD; 1.
DR SMART; SM00498; FH2; 1.
DR SUPFAM; SSF48371; ARM repeat; 1.
DR SUPFAM; SSF101447; Formin homology 2 domain (FH2 domain); 1.
DR PROSITE; PS51231; DAD; 1.
DR PROSITE; PS51444; FH2; 1.
DR PROSITE; PS51232; GBD_FH3; 1.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW Reference proteome {ECO:0000313|Proteomes:UP000002281}.
FT DOMAIN 48..427
FT /note="GBD/FH3"
FT /evidence="ECO:0000259|PROSITE:PS51232"
FT DOMAIN 587..985
FT /note="FH2"
FT /evidence="ECO:0000259|PROSITE:PS51444"
FT DOMAIN 1008..1038
FT /note="DAD"
FT /evidence="ECO:0000259|PROSITE:PS51231"
FT REGION 1..59
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 509..587
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 464..501
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 866..928
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 960..1006
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 15..30
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 524..584
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1144 AA; 131081 MW; E9B84D0AF663158F CRC64;
MDRHRPRLHH PAQSSSAGAP CSSSALPRSS RESKMPRRKG PQHPPPPGGL EEPGEKRPKF
LDKFASIRIP GSKKERPPLS NLKTAFASND CSSEMMENIP KPLSENELLE LFEKMMGSLK
RSRQISSQEF IYELKMGCAD ERLVTCLESL RVSLTSNPVS WVESFGHEGL GLLLDILEKL
ISGKIQEKIV KKNQHKVIQC LKALMNTQYG LERIMSEERS LSLLAKAIDP EHPNMMTDVV
KLLSAVCIVG EENILEEVLE ALTTAGEERK IDRFFSIVEG LRHNSVQLQV ACMQLINALV
TSPDDLDFRL HIRNEFMRCG LKEMLPNLKR IKNDGLDIQL KVFDEHKEED LIEFSHRLED
IRAELDEAYD VYNMVWNTVK ETRAEGYFIS ILQHLLLIRN DYFIRQQYFK LIDECVSQIV
LHRDGMDPDF TYRKRLDLDL SQFVDICIDQ AKLEEFEEKA SDLFKKFEKE FTDHQETQAQ
LQKKEAEINE LQAELQAFKS QFGALPAGTN TSLPLSKENG TSHPALPPAP PLPFCGGAPP
PPPPPPPPPL PGMPMPFGGP VPPPPPLGFL SGRNSPPPPA LPFGLKPKKE FKPEANMRRL
NWLKIRPHEM TENCFWIKAN ENKYENIDLL CKLENTFCCQ QKEKREEDDF EEKKAIKKKI
KELKFLDSKI AQNLSIFLSS FRVPYEEIKM MILEVDETQL AESMIQNLIK HLPDQEQLNS
LSQFKSDYNN LCEPEQFAVV MSNVKRLRPR LSAILFKLQF EEQVNNIKPD IMAVSTACEE
IKKSRSFSKL LELVLLMGNY MNAGSRNAQT FGFNLSSLCK LKDTKSADQK TTLLHFLVEV
CEEKYPDILN FVDDMEHLDK ASKVSVETLE KNLKQMGRQL QQLEKDLETF PPPEDLHDKF
VTKMSSFVIS AKEQYEKLSK LHENMEKLYQ SIMQYYAIDV KKVSVEDFLT DLNNFRTTVM
QAIKENVKKR EAEEREKRAR IAKELAEKER LERQQKKKRL LEMKTEGDET GVMDSLLEAL
QSGAAFRDRR KRTPKPKDIR QSLSPMSQRP ILKVCNHENQ KGQLTEGSRS HYNINCNSAR
TPVAKELNYN LDTPTSTGRI KAVEKKEACN VESNRKKEME LLGSVSKNES IPEVEALLAR
LRAL
//
