ID A0A3Q2HRI5_HORSE Unreviewed; 1263 AA.
AC A0A3Q2HRI5;
DT 10-APR-2019, integrated into UniProtKB/TrEMBL.
DT 11-DEC-2019, sequence version 2.
DT 27-MAR-2024, entry version 23.
DE SubName: Full=Kinesin family member 16B {ECO:0000313|Ensembl:ENSECAP00000037594.2};
GN Name=KIF16B {ECO:0000313|Ensembl:ENSECAP00000037594.2,
GN ECO:0000313|VGNC:VGNC:19396};
OS Equus caballus (Horse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Perissodactyla; Equidae; Equus.
OX NCBI_TaxID=9796 {ECO:0000313|Ensembl:ENSECAP00000037594.2, ECO:0000313|Proteomes:UP000002281};
RN [1] {ECO:0000313|Ensembl:ENSECAP00000037594.2, ECO:0000313|Proteomes:UP000002281}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Thoroughbred {ECO:0000313|Ensembl:ENSECAP00000037594.2,
RC ECO:0000313|Proteomes:UP000002281};
RX PubMed=19892987; DOI=10.1126/science.1178158;
RG Broad Institute Genome Sequencing Platform;
RG Broad Institute Whole Genome Assembly Team;
RA Wade C.M., Giulotto E., Sigurdsson S., Zoli M., Gnerre S., Imsland F.,
RA Lear T.L., Adelson D.L., Bailey E., Bellone R.R., Bloecker H., Distl O.,
RA Edgar R.C., Garber M., Leeb T., Mauceli E., MacLeod J.N., Penedo M.C.T.,
RA Raison J.M., Sharpe T., Vogel J., Andersson L., Antczak D.F., Biagi T.,
RA Binns M.M., Chowdhary B.P., Coleman S.J., Della Valle G., Fryc S.,
RA Guerin G., Hasegawa T., Hill E.W., Jurka J., Kiialainen A., Lindgren G.,
RA Liu J., Magnani E., Mickelson J.R., Murray J., Nergadze S.G., Onofrio R.,
RA Pedroni S., Piras M.F., Raudsepp T., Rocchi M., Roeed K.H., Ryder O.A.,
RA Searle S., Skow L., Swinburne J.E., Syvaenen A.C., Tozaki T., Valberg S.J.,
RA Vaudin M., White J.R., Zody M.C., Lander E.S., Lindblad-Toh K.;
RT "Genome sequence, comparative analysis, and population genetics of the
RT domestic horse.";
RL Science 326:865-867(2009).
RN [2] {ECO:0000313|Ensembl:ENSECAP00000037594.2}
RP IDENTIFICATION.
RC STRAIN=Thoroughbred {ECO:0000313|Ensembl:ENSECAP00000037594.2};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the TRAFAC class myosin-kinesin ATPase
CC superfamily. Kinesin family. {ECO:0000256|PROSITE-ProRule:PRU00283}.
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DR AlphaFoldDB; A0A3Q2HRI5; -.
DR Ensembl; ENSECAT00000056616.3; ENSECAP00000037594.2; ENSECAG00000007559.4.
DR VGNC; VGNC:19396; KIF16B.
DR GeneTree; ENSGT00940000162977; -.
DR Proteomes; UP000002281; Chromosome 22.
DR Bgee; ENSECAG00000007559; Expressed in liver and 23 other cell types or tissues.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0008017; F:microtubule binding; IEA:InterPro.
DR GO; GO:0003777; F:microtubule motor activity; IEA:InterPro.
DR GO; GO:0035091; F:phosphatidylinositol binding; IEA:InterPro.
DR GO; GO:0007018; P:microtubule-based movement; IEA:InterPro.
DR CDD; cd22732; FHA_KIF16B; 1.
DR CDD; cd01365; KISc_KIF1A_KIF1B; 1.
DR CDD; cd06874; PX_KIF16B_SNX23; 1.
DR Gene3D; 2.60.200.20; -; 1.
DR Gene3D; 3.40.850.10; Kinesin motor domain; 1.
DR Gene3D; 3.30.1520.10; Phox-like domain; 1.
DR InterPro; IPR000253; FHA_dom.
DR InterPro; IPR019821; Kinesin_motor_CS.
DR InterPro; IPR001752; Kinesin_motor_dom.
DR InterPro; IPR036961; Kinesin_motor_dom_sf.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR001683; PX_dom.
DR InterPro; IPR036871; PX_dom_sf.
DR InterPro; IPR008984; SMAD_FHA_dom_sf.
DR PANTHER; PTHR47117:SF6; KINESIN-LIKE PROTEIN KIF1C ISOFORM X1; 1.
DR PANTHER; PTHR47117; STAR-RELATED LIPID TRANSFER PROTEIN 9; 1.
DR Pfam; PF00498; FHA; 1.
DR Pfam; PF00225; Kinesin; 1.
DR Pfam; PF00787; PX; 1.
DR PRINTS; PR00380; KINESINHEAVY.
DR SMART; SM00129; KISc; 1.
DR SMART; SM00312; PX; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF64268; PX domain; 1.
DR SUPFAM; SSF49879; SMAD/FHA domain; 1.
DR PROSITE; PS00411; KINESIN_MOTOR_1; 1.
DR PROSITE; PS50067; KINESIN_MOTOR_2; 1.
DR PROSITE; PS50195; PX; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|PROSITE-
KW ProRule:PRU00283};
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW Motor protein {ECO:0000256|PROSITE-ProRule:PRU00283};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|PROSITE-
KW ProRule:PRU00283}; Reference proteome {ECO:0000313|Proteomes:UP000002281}.
FT DOMAIN 3..358
FT /note="Kinesin motor"
FT /evidence="ECO:0000259|PROSITE:PS50067"
FT DOMAIN 1128..1242
FT /note="PX"
FT /evidence="ECO:0000259|PROSITE:PS50195"
FT REGION 1033..1054
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 373..421
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 599..807
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 833..871
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 939..1019
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 1033..1048
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT BINDING 102..109
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00283"
SQ SEQUENCE 1263 AA; 145596 MW; 97CA88152ECA9713 CRC64;
MASVKVAVRV RPMNRREKDL EAKFIIHMEK SKTTITNLKI PEGGTGDSGR ERTKTFTYDF
SFYSADTKSP DYVSQEMVFK TLGTDVVKSA FEGYNACVFA YGQTGSGKSY TMMGDSGDSG
LIPRICEGLF SRINETTRWD EASFRTEVSY LEIYNEHVRD LLRRKSSKTF NLRVREHPKE
GPYVEDLSKH LVQNYGDVEE LMDAGNINRT TAATGMNDVS SRSHAIFTIK FTQAKFDSEM
PCETVSKIHL VDLAGSERAD ATGATGVRLK EGGNINKSLV TLGNVISALA DLSQDAANPL
VKKKQVFVPY RDSVLTWLLK DSLGGNSKTI MIATISPADV NYGETLSTLR YANRAKNIIN
KPTINEDANV KLIRELRAEI ARLKTLLAQG NQIALLDSPT ALSMEEKLQQ NEARVQELTK
EWTNKWNETQ NILKEQTLAL RKEGIGVVLD SELPHLIGID DDLLSTGIIL YHLKEGQTYV
GREDASTEQD IVLHGLDLES EHCIFENVGG TVTLIPLSGS QCSVNGVQIT EATHLNQGAV
ILLGRTNMFR FNHPKEAAKL REKRKSGLLS SFSLSMTDLS KSCENLSAVM LYNPGLEFER
QQREELEKLE SKRKLIEEME EKQKSDKAEL ERMQQEVETQ RRETEIVQLQ IRKQEESLKR
RSVHIESKLK DLLAEKEKFE EERLREQQEI ELQKKKQEEE SFLRVKEELQ RLQELNHNEK
AEKTQIFQEL DQLKKEKDEQ YAKFELEKKR LEEQEKEQVM LVAHLEEQLR EKQEMIGLLR
RGEVQRVEEE KRALEGIREA LLRVKEARAE GDDDGEELER AQLHFLEFKS RQLVKLANLE
KDLVQQKDLL EKEVEEEKEI LERLKSENEE EFGLLEKNDD SVTLGTQNLE RIKPAEYRLQ
YKERQLQYLL QNRLPTLLEE KQRAFEILDR GPLGLDNTLY QVEKEMEEKE EQLARYQANA
SQLQKLQATF EFTANIARQE EKVRRKEKEI LESREKQQRE ALERAVARLE RRHSALQRRS
TLGVEIEEQR QKLATLNSSS SEQSGLRASL EAEQEALERD QERINAYIEE EVQRRLQDLH
HVIGSDSNTS ADLMKDNEKL HNGTIQRKLK YERMVSRSLG ANPDDLKDPI KISIPRYVLC
GQGKDEHFEF EVKITVLDET WTVFRRYSRF REMHKTLKLK YAELATLEFP PKKLFGNKDE
RVVAERRSHL EKYLRDFFSV MLQSATSPLH ISKVGLTLSK HTICEFSPFF KKGVFDYSSH
GTG
//