ID A0A3Q2HSJ8_HORSE Unreviewed; 880 AA.
AC A0A3Q2HSJ8;
DT 10-APR-2019, integrated into UniProtKB/TrEMBL.
DT 13-SEP-2023, sequence version 3.
DT 27-MAR-2024, entry version 20.
DE SubName: Full=Striated muscle enriched protein kinase {ECO:0000313|Ensembl:ENSECAP00000038130.3};
GN Name=SPEG {ECO:0000313|Ensembl:ENSECAP00000038130.3};
OS Equus caballus (Horse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Perissodactyla; Equidae; Equus.
OX NCBI_TaxID=9796 {ECO:0000313|Ensembl:ENSECAP00000038130.3, ECO:0000313|Proteomes:UP000002281};
RN [1] {ECO:0000313|Ensembl:ENSECAP00000038130.3, ECO:0000313|Proteomes:UP000002281}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Thoroughbred {ECO:0000313|Ensembl:ENSECAP00000038130.3,
RC ECO:0000313|Proteomes:UP000002281};
RX PubMed=19892987; DOI=10.1126/science.1178158;
RG Broad Institute Genome Sequencing Platform;
RG Broad Institute Whole Genome Assembly Team;
RA Wade C.M., Giulotto E., Sigurdsson S., Zoli M., Gnerre S., Imsland F.,
RA Lear T.L., Adelson D.L., Bailey E., Bellone R.R., Bloecker H., Distl O.,
RA Edgar R.C., Garber M., Leeb T., Mauceli E., MacLeod J.N., Penedo M.C.T.,
RA Raison J.M., Sharpe T., Vogel J., Andersson L., Antczak D.F., Biagi T.,
RA Binns M.M., Chowdhary B.P., Coleman S.J., Della Valle G., Fryc S.,
RA Guerin G., Hasegawa T., Hill E.W., Jurka J., Kiialainen A., Lindgren G.,
RA Liu J., Magnani E., Mickelson J.R., Murray J., Nergadze S.G., Onofrio R.,
RA Pedroni S., Piras M.F., Raudsepp T., Rocchi M., Roeed K.H., Ryder O.A.,
RA Searle S., Skow L., Swinburne J.E., Syvaenen A.C., Tozaki T., Valberg S.J.,
RA Vaudin M., White J.R., Zody M.C., Lander E.S., Lindblad-Toh K.;
RT "Genome sequence, comparative analysis, and population genetics of the
RT domestic horse.";
RL Science 326:865-867(2009).
RN [2] {ECO:0000313|Ensembl:ENSECAP00000038130.3}
RP IDENTIFICATION.
RC STRAIN=Thoroughbred {ECO:0000313|Ensembl:ENSECAP00000038130.3};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR AlphaFoldDB; A0A3Q2HSJ8; -.
DR Ensembl; ENSECAT00000043704.3; ENSECAP00000038130.3; ENSECAG00000000174.4.
DR GeneTree; ENSGT00940000161126; -.
DR OMA; TWPWPLP; -.
DR Proteomes; UP000002281; Chromosome 6.
DR Bgee; ENSECAG00000000174; Expressed in triceps brachii and 18 other cell types or tissues.
DR ExpressionAtlas; A0A3Q2HSJ8; baseline.
DR GO; GO:0003779; F:actin binding; IEA:UniProtKB-KW.
DR CDD; cd20975; IgI_APEG-1_like; 1.
DR Gene3D; 2.60.40.10; Immunoglobulins; 2.
DR InterPro; IPR007110; Ig-like_dom.
DR InterPro; IPR036179; Ig-like_dom_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR013098; Ig_I-set.
DR InterPro; IPR003599; Ig_sub.
DR InterPro; IPR003598; Ig_sub2.
DR PANTHER; PTHR47633; IMMUNOGLOBULIN; 1.
DR PANTHER; PTHR47633:SF3; STRIATED MUSCLE PREFERENTIALLY EXPRESSED PROTEIN KINASE; 1.
DR Pfam; PF07679; I-set; 2.
DR Pfam; PF16650; SPEG_u2; 1.
DR SMART; SM00409; IG; 2.
DR SMART; SM00408; IGc2; 2.
DR SUPFAM; SSF48726; Immunoglobulin; 2.
DR PROSITE; PS50835; IG_LIKE; 2.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000002281}.
FT DOMAIN 640..728
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 787..876
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT REGION 1..37
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 50..149
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 196..633
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 730..789
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 50..69
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 79..121
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 216..261
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 262..281
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 283..303
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 324..340
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 389..405
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 413..434
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 467..482
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 503..517
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 579..601
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 766..789
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 880 AA; 95486 MW; F7934A0BD3FA6120 CRC64;
VPSSPGRRPG PLPRHEEAVG EEALPENRPL PQGLWPTHPC EVFRSCRKQS YDSETGEDDI
SDVQGTQRLE LRDDGAFSTP TGGSDTLVGT SLDTPPTSVT GTSEEQVSWW GSGQTVLEQE
AGSRGGTRRL PGSPRQAQAT GAGPRHLGVE PLVRASRANL VGASWGSEDS LSVASDPYGS
AFSLYRGRAL SIHVSVPQSG LHREEPDLQP QPASEAPRRP ALPPPSKSAL LPPPSPRVGK
RPPPGPSAQP PATPTPPHRR TQEPVLPEDT TAEEKRGKKS KSSGPSLAGT AESRPQSPLS
EASGRLSALG RSPRLVRAGS RILDKLQFFE ERRRSLERSD SPPAPLRPWV PLRKARSLEQ
PKSEGAPWGT QEELRAPAGS VAERRRLFQQ KAASLDERTR QRSPASDLEL RFAQELGRIR
RSTSREELVR SHESLRATLQ RAPSPREPGE PPLFSRPSTP KTPRAVSPVA AQPPPPSVAG
RPEDEPGRPL SRGPAGRTES GEGPQQEVRR REQFPLTRGR AIQECRSPVP PPAAEPPEAR
TKAPPGRKRE PPAQAVRFLP WATPGQEGAA VPQTLEKNRA GPEAEKRLRR GLEEDGPWGA
WDRRGARSQG RGRRARPTSP ELESSDDSYV SAGEEPLEAP VFEIPLQNAV VAPGADVLLK
CIVTANPPPQ VSWRKDGSPL RSDGRLLIRA EGERHTLLLR EARAADAGNY TATATNELGQ
ASCAAALAVR PGGSTSPFSS PITSDEEYLS PPEEFPEPGE TWPRTPTMKL SPSQNRRSSD
TSSKAPPTFK VSLMDQSVRE GQDVTMSIRV QGEPKPVVSW LRNRQPVRPD QRRFAEEAEG
GLCRLRILAA ERGDAGFYTC KAVNEYGARQ CEARLEVRGE
//
