ID A0A3Q2HT73_HORSE Unreviewed; 967 AA.
AC A0A3Q2HT73;
DT 10-APR-2019, integrated into UniProtKB/TrEMBL.
DT 13-SEP-2023, sequence version 2.
DT 27-MAR-2024, entry version 24.
DE RecName: Full=Exportin-T {ECO:0000256|ARBA:ARBA00018928, ECO:0000256|RuleBase:RU366037};
DE AltName: Full=Exportin(tRNA) {ECO:0000256|ARBA:ARBA00029784, ECO:0000256|RuleBase:RU366037};
DE AltName: Full=tRNA exportin {ECO:0000256|ARBA:ARBA00032199, ECO:0000256|RuleBase:RU366037};
GN Name=XPOT {ECO:0000313|Ensembl:ENSECAP00000038410.2,
GN ECO:0000313|VGNC:VGNC:25080};
OS Equus caballus (Horse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Perissodactyla; Equidae; Equus.
OX NCBI_TaxID=9796 {ECO:0000313|Ensembl:ENSECAP00000038410.2, ECO:0000313|Proteomes:UP000002281};
RN [1] {ECO:0000313|Ensembl:ENSECAP00000038410.2, ECO:0000313|Proteomes:UP000002281}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Thoroughbred {ECO:0000313|Ensembl:ENSECAP00000038410.2,
RC ECO:0000313|Proteomes:UP000002281};
RX PubMed=19892987; DOI=10.1126/science.1178158;
RG Broad Institute Genome Sequencing Platform;
RG Broad Institute Whole Genome Assembly Team;
RA Wade C.M., Giulotto E., Sigurdsson S., Zoli M., Gnerre S., Imsland F.,
RA Lear T.L., Adelson D.L., Bailey E., Bellone R.R., Bloecker H., Distl O.,
RA Edgar R.C., Garber M., Leeb T., Mauceli E., MacLeod J.N., Penedo M.C.T.,
RA Raison J.M., Sharpe T., Vogel J., Andersson L., Antczak D.F., Biagi T.,
RA Binns M.M., Chowdhary B.P., Coleman S.J., Della Valle G., Fryc S.,
RA Guerin G., Hasegawa T., Hill E.W., Jurka J., Kiialainen A., Lindgren G.,
RA Liu J., Magnani E., Mickelson J.R., Murray J., Nergadze S.G., Onofrio R.,
RA Pedroni S., Piras M.F., Raudsepp T., Rocchi M., Roeed K.H., Ryder O.A.,
RA Searle S., Skow L., Swinburne J.E., Syvaenen A.C., Tozaki T., Valberg S.J.,
RA Vaudin M., White J.R., Zody M.C., Lander E.S., Lindblad-Toh K.;
RT "Genome sequence, comparative analysis, and population genetics of the
RT domestic horse.";
RL Science 326:865-867(2009).
RN [2] {ECO:0000313|Ensembl:ENSECAP00000038410.2}
RP IDENTIFICATION.
RC STRAIN=Thoroughbred {ECO:0000313|Ensembl:ENSECAP00000038410.2};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- FUNCTION: tRNA nucleus export receptor which facilitates tRNA
CC translocation across the nuclear pore complex.
CC {ECO:0000256|RuleBase:RU366037}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496,
CC ECO:0000256|RuleBase:RU366037}. Nucleus
CC {ECO:0000256|RuleBase:RU366037}. Note=Shuttles between the nucleus and
CC the cytoplasm. {ECO:0000256|RuleBase:RU366037}.
CC -!- SIMILARITY: Belongs to the exportin family.
CC {ECO:0000256|RuleBase:RU366037}.
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DR AlphaFoldDB; A0A3Q2HT73; -.
DR Ensembl; ENSECAT00000051862.2; ENSECAP00000038410.2; ENSECAG00000018336.3.
DR VGNC; VGNC:25080; XPOT.
DR GeneTree; ENSGT00390000007890; -.
DR Proteomes; UP000002281; Chromosome 6.
DR Bgee; ENSECAG00000018336; Expressed in trophectoderm and 23 other cell types or tissues.
DR ExpressionAtlas; A0A3Q2HT73; baseline.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0031267; F:small GTPase binding; IEA:InterPro.
DR GO; GO:0000049; F:tRNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0006886; P:intracellular protein transport; IEA:InterPro.
DR GO; GO:0071528; P:tRNA re-export from nucleus; IEA:UniProtKB-UniRule.
DR Gene3D; 1.25.10.10; Leucine-rich Repeat Variant; 1.
DR InterPro; IPR011989; ARM-like.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR013598; Exportin-1/Importin-b-like.
DR InterPro; IPR045546; Exportin-T_C.
DR InterPro; IPR001494; Importin-beta_N.
DR InterPro; IPR040017; XPOT.
DR PANTHER; PTHR15952:SF11; EXPORTIN-T; 1.
DR PANTHER; PTHR15952; EXPORTIN-T/LOS1; 1.
DR Pfam; PF19282; Exportin-T; 1.
DR Pfam; PF03810; IBN_N; 1.
DR Pfam; PF08389; Xpo1; 1.
DR SMART; SM00913; IBN_N; 1.
DR SUPFAM; SSF48371; ARM repeat; 1.
PE 3: Inferred from homology;
KW Cytoplasm {ECO:0000256|RuleBase:RU366037};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242, ECO:0000256|RuleBase:RU366037};
KW Reference proteome {ECO:0000313|Proteomes:UP000002281};
KW RNA-binding {ECO:0000256|ARBA:ARBA00022884, ECO:0000256|RuleBase:RU366037};
KW Transport {ECO:0000256|RuleBase:RU366037};
KW tRNA-binding {ECO:0000256|ARBA:ARBA00022555,
KW ECO:0000256|RuleBase:RU366037}.
FT DOMAIN 45..113
FT /note="Importin N-terminal"
FT /evidence="ECO:0000259|SMART:SM00913"
FT REGION 1..20
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 967 AA; 110175 MW; 543255FB09721165 CRC64;
MFVEPSVGSE GACRSQQTPR TAARMDEQAL LGLNPNADSD FRQRALAYFE QLKISPDAWQ
ACAEALAQRT YSDDHIKFFC FQVLEHQVKY KYSELTTIQQ QLIRETLISW LQAQMLNPQP
EKTFIRNKAA QVFALLFVTE YLTKWPKFFF DILSVVGLNS RGVDLYLRIL MAIDSELVDR
DVVHTSEEAR RNTLIKDTMR EQCIPNLVES WYQILQNYQY TNSEVTCQCL EVVGAYVSWI
DLSLIANDRF INMLLGHMSI EVLREEACDC LFEIVNKGMD PVDKMKLVES LCQVLQSAGF
FSIDQEEDVD FLARFSKLVN GMGQSLIVSW TKLIKNGDIK NAQEALQAIE TKVALMLQLL
IHEDDDISSN IIGFCYDYLH ILKQLTVLSD QQKANVEAIM LAVMKKLTYD EEYNFENEGE
DEAMFVEYRK QLKLLLDRLA QVSPELLLAS VRRVFSSTLQ NWQTTRFMEV EVAIRLLYML
AEALPVSHGA HFSGDVSKAS ALQDMMRTLV TSGVSSYQHT SVTLEFFETV VRYEKFFTVE
PQHIPCVLMA FLDHRGLRHA SAKVRSRTAY LFSRFVKSLN KQMNPFIEDI LNRIQDLLEL
SPPENGYQSL LSSDDQLFIY ETAGVLIVNS EYPAERKQAL MRNLLTPLME KFKILLEKLM
LAQDEERQAS LADCLNHAVG FASRTSKAFS NKQTVKQCGC SEVYLDCLQT FLPALSCPLQ
KDVLRSGVRT FLHRMIICLE EEVLPFIPSA SEHMLKDCEA KDLQELIPLI NQITAKFKVQ
VSPFLQQMFM PLLRAIFEVL LRPAEDNDQS AALEKQMLRR SYFAFLQTVT GSGMSEVVAN
QGAENVERVL VTVIQGAVEY PDPIAQKTCF IILSKLVELW GGEDGPVGFA DFVYKHIVPA
CFLAPLKQTF DLADAQTVLA LSECAVTLKT IHLKRGPECV QYLQQEYLPS LQVAPEIIQV
FFQRAKP
//
