ID A0A3Q2HU00_HORSE Unreviewed; 988 AA.
AC A0A3Q2HU00;
DT 10-APR-2019, integrated into UniProtKB/TrEMBL.
DT 10-APR-2019, sequence version 1.
DT 27-MAR-2024, entry version 22.
DE SubName: Full=FERM domain containing 4B {ECO:0000313|Ensembl:ENSECAP00000038555.1};
GN Name=FRMD4B {ECO:0000313|Ensembl:ENSECAP00000038555.1,
GN ECO:0000313|VGNC:VGNC:18128};
OS Equus caballus (Horse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Perissodactyla; Equidae; Equus.
OX NCBI_TaxID=9796 {ECO:0000313|Ensembl:ENSECAP00000038555.1, ECO:0000313|Proteomes:UP000002281};
RN [1] {ECO:0000313|Ensembl:ENSECAP00000038555.1, ECO:0000313|Proteomes:UP000002281}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Thoroughbred {ECO:0000313|Ensembl:ENSECAP00000038555.1,
RC ECO:0000313|Proteomes:UP000002281};
RX PubMed=19892987; DOI=10.1126/science.1178158;
RG Broad Institute Genome Sequencing Platform;
RG Broad Institute Whole Genome Assembly Team;
RA Wade C.M., Giulotto E., Sigurdsson S., Zoli M., Gnerre S., Imsland F.,
RA Lear T.L., Adelson D.L., Bailey E., Bellone R.R., Bloecker H., Distl O.,
RA Edgar R.C., Garber M., Leeb T., Mauceli E., MacLeod J.N., Penedo M.C.T.,
RA Raison J.M., Sharpe T., Vogel J., Andersson L., Antczak D.F., Biagi T.,
RA Binns M.M., Chowdhary B.P., Coleman S.J., Della Valle G., Fryc S.,
RA Guerin G., Hasegawa T., Hill E.W., Jurka J., Kiialainen A., Lindgren G.,
RA Liu J., Magnani E., Mickelson J.R., Murray J., Nergadze S.G., Onofrio R.,
RA Pedroni S., Piras M.F., Raudsepp T., Rocchi M., Roeed K.H., Ryder O.A.,
RA Searle S., Skow L., Swinburne J.E., Syvaenen A.C., Tozaki T., Valberg S.J.,
RA Vaudin M., White J.R., Zody M.C., Lander E.S., Lindblad-Toh K.;
RT "Genome sequence, comparative analysis, and population genetics of the
RT domestic horse.";
RL Science 326:865-867(2009).
RN [2] {ECO:0000313|Ensembl:ENSECAP00000038555.1}
RP IDENTIFICATION.
RC STRAIN=Thoroughbred {ECO:0000313|Ensembl:ENSECAP00000038555.1};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR AlphaFoldDB; A0A3Q2HU00; -.
DR Ensembl; ENSECAT00000037284.2; ENSECAP00000038555.1; ENSECAG00000016131.4.
DR VGNC; VGNC:18128; FRMD4B.
DR GeneTree; ENSGT01020000230354; -.
DR Proteomes; UP000002281; Chromosome 16.
DR Bgee; ENSECAG00000016131; Expressed in retina and 23 other cell types or tissues.
DR ExpressionAtlas; A0A3Q2HU00; baseline.
DR GO; GO:0005856; C:cytoskeleton; IEA:InterPro.
DR GO; GO:0090162; P:establishment of epithelial cell polarity; IEA:InterPro.
DR CDD; cd14473; FERM_B-lobe; 1.
DR CDD; cd13191; FERM_C_FRMD4A_FRMD4B; 1.
DR CDD; cd17200; FERM_F1_FRMD4B; 1.
DR Gene3D; 1.20.80.10; -; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR InterPro; IPR019749; Band_41_domain.
DR InterPro; IPR021774; CUPID.
DR InterPro; IPR014352; FERM/acyl-CoA-bd_prot_sf.
DR InterPro; IPR035963; FERM_2.
DR InterPro; IPR019748; FERM_central.
DR InterPro; IPR019747; FERM_CS.
DR InterPro; IPR000299; FERM_domain.
DR InterPro; IPR018979; FERM_N.
DR InterPro; IPR018980; FERM_PH-like_C.
DR InterPro; IPR047176; FRMD4A/B.
DR InterPro; IPR041785; FRMD4A/B_FERM_C.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR029071; Ubiquitin-like_domsf.
DR PANTHER; PTHR46079; FERM DOMAIN-CONTAINING PROTEIN 4; 1.
DR PANTHER; PTHR46079:SF1; FERM DOMAIN-CONTAINING PROTEIN 4B; 1.
DR Pfam; PF11819; CUPID; 1.
DR Pfam; PF09380; FERM_C; 1.
DR Pfam; PF00373; FERM_M; 1.
DR Pfam; PF09379; FERM_N; 1.
DR PRINTS; PR00935; BAND41.
DR SMART; SM00295; B41; 1.
DR SMART; SM01196; FERM_C; 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR SUPFAM; SSF47031; Second domain of FERM; 1.
DR SUPFAM; SSF54236; Ubiquitin-like; 1.
DR PROSITE; PS00661; FERM_2; 1.
DR PROSITE; PS50057; FERM_3; 1.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Reference proteome {ECO:0000313|Proteomes:UP000002281}.
FT DOMAIN 13..315
FT /note="FERM"
FT /evidence="ECO:0000259|PROSITE:PS50057"
FT REGION 590..653
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 667..690
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 708..741
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 860..880
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 947..970
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 485..512
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 590..607
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 618..653
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 724..741
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 863..880
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 947..962
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 988 AA; 112281 MW; 7C455583F38D0461 CRC64;
MSQDHGSEMT EGRHCQVHLL DDRRLELLVQ PKLLSRELLD LVASHFNLKE KEYFGITFTD
DTGHQNWLQL DHRVLDHDLP KKQGPTILHF AVRFYIESIS FLKDKTTVEL FFLNAKSCVH
KGQIEVDSET TFKLAALVLQ EAKGDYTSDE NARKDLKTLP AFPTKTLQEH PSLAYCEDRV
IEHYLKVKGL TRGQAVVQYM KIVEALPTYG VHYYAVKDKQ GLPWWLGISY KGIGQYDLQD
KVKPRKLFQW KQLENLYFRE KKFAVEVHDP RRISVSRRTF GQSGLFVQTW YANSSLIKSI
WVMAISQHQF YLDRKQSKAK IPSARSLDDI AMDLTETGTP RVSKLVTLEA KSQFIMASNG
SLISSGSQDS EVSEEQKREK ILELKKKEKL LQEKLLKKVE ELKKICLREA ELTGKIPKEY
PLNIGEKPPQ VRRRVGTAFK LDDNLLPSEE DPALQELESN FLIQQKLVEA AKKLANEPDL
CKTVKKKRKQ DYADAVKKLQ EIENAINEYR IRCGKKPSQK ATVILPEDII PSESSSLSDT
ATYDDPNDTF AVAGQRSSSV PHSPRILPPK SLGIERIHFR KSSINEQFVD TRQSREMLST
HSSPYKTLER RPQGGRSMPT TPVLTRNAYS SSHLEPESSS QHCRQRSGSL ESQSHLLSEM
ENDKPFFSLS KSQRSSSTEI LDDGSSYTSQ SSTEYYCVTP VAGPYYTTQT LDTRARGRRR
SKKQNVSTSN SGSMPNLAQK DSLRNGVYSK SQEQPSSSYY IAGYTPYTEC DLYYSGGYVY
ENDTEGQYSV NPSYRSSAHY GYDRQRDYSR SFHEDEVDRV PHNPYATLRL PRKAAAKSEH
ITKNIHKALV AEHLRGWYQR ASGQKEQGHS PQTSFDSDRG SQRCLGFAGL QIPCSPSSRA
SSYSSVSSTN ASGNWRTQIT VGLSEYETPA HSYTSCYGNI YNPLPSPGRQ YTETSQLDGT
DGNRLEDSLD SSEQRLFWHE DSKPGTLV
//
