ID A0A3Q2HUV0_HORSE Unreviewed; 901 AA.
AC A0A3Q2HUV0;
DT 10-APR-2019, integrated into UniProtKB/TrEMBL.
DT 13-SEP-2023, sequence version 2.
DT 27-MAR-2024, entry version 21.
DE SubName: Full=PPFIA binding protein 2 {ECO:0000313|Ensembl:ENSECAP00000038850.2};
GN Name=PPFIBP2 {ECO:0000313|Ensembl:ENSECAP00000038850.2,
GN ECO:0000313|VGNC:VGNC:21726};
OS Equus caballus (Horse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Perissodactyla; Equidae; Equus.
OX NCBI_TaxID=9796 {ECO:0000313|Ensembl:ENSECAP00000038850.2, ECO:0000313|Proteomes:UP000002281};
RN [1] {ECO:0000313|Ensembl:ENSECAP00000038850.2, ECO:0000313|Proteomes:UP000002281}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Thoroughbred {ECO:0000313|Ensembl:ENSECAP00000038850.2,
RC ECO:0000313|Proteomes:UP000002281};
RX PubMed=19892987; DOI=10.1126/science.1178158;
RG Broad Institute Genome Sequencing Platform;
RG Broad Institute Whole Genome Assembly Team;
RA Wade C.M., Giulotto E., Sigurdsson S., Zoli M., Gnerre S., Imsland F.,
RA Lear T.L., Adelson D.L., Bailey E., Bellone R.R., Bloecker H., Distl O.,
RA Edgar R.C., Garber M., Leeb T., Mauceli E., MacLeod J.N., Penedo M.C.T.,
RA Raison J.M., Sharpe T., Vogel J., Andersson L., Antczak D.F., Biagi T.,
RA Binns M.M., Chowdhary B.P., Coleman S.J., Della Valle G., Fryc S.,
RA Guerin G., Hasegawa T., Hill E.W., Jurka J., Kiialainen A., Lindgren G.,
RA Liu J., Magnani E., Mickelson J.R., Murray J., Nergadze S.G., Onofrio R.,
RA Pedroni S., Piras M.F., Raudsepp T., Rocchi M., Roeed K.H., Ryder O.A.,
RA Searle S., Skow L., Swinburne J.E., Syvaenen A.C., Tozaki T., Valberg S.J.,
RA Vaudin M., White J.R., Zody M.C., Lander E.S., Lindblad-Toh K.;
RT "Genome sequence, comparative analysis, and population genetics of the
RT domestic horse.";
RL Science 326:865-867(2009).
RN [2] {ECO:0000313|Ensembl:ENSECAP00000038850.2}
RP IDENTIFICATION.
RC STRAIN=Thoroughbred {ECO:0000313|Ensembl:ENSECAP00000038850.2};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the liprin family. Liprin-beta subfamily.
CC {ECO:0000256|ARBA:ARBA00007547}.
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DR AlphaFoldDB; A0A3Q2HUV0; -.
DR Ensembl; ENSECAT00000035313.3; ENSECAP00000038850.2; ENSECAG00000012953.4.
DR VGNC; VGNC:21726; PPFIBP2.
DR GeneTree; ENSGT01050000244951; -.
DR Proteomes; UP000002281; Chromosome 7.
DR Bgee; ENSECAG00000012953; Expressed in zone of skin and 23 other cell types or tissues.
DR ExpressionAtlas; A0A3Q2HUV0; baseline.
DR CDD; cd09563; SAM_liprin-beta1_2_repeat1; 1.
DR CDD; cd09566; SAM_liprin-beta1_2_repeat2; 1.
DR CDD; cd09569; SAM_liprin-beta1_2_repeat3; 1.
DR Gene3D; 1.10.150.50; Transcription Factor, Ets-1; 3.
DR InterPro; IPR029515; Liprin.
DR InterPro; IPR037617; Liprin-beta_SAM_rpt_1.
DR InterPro; IPR037618; Liprin-beta_SAM_rpt_2.
DR InterPro; IPR037619; Liprin-beta_SAM_rpt_3.
DR InterPro; IPR001660; SAM.
DR InterPro; IPR013761; SAM/pointed_sf.
DR PANTHER; PTHR12587; LAR INTERACTING PROTEIN LIP -RELATED PROTEIN; 1.
DR PANTHER; PTHR12587:SF18; LIPRIN-BETA-2; 1.
DR Pfam; PF00536; SAM_1; 2.
DR Pfam; PF07647; SAM_2; 1.
DR SMART; SM00454; SAM; 3.
DR SUPFAM; SSF47769; SAM/Pointed domain; 3.
DR PROSITE; PS50105; SAM_DOMAIN; 3.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW Reference proteome {ECO:0000313|Proteomes:UP000002281};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT DOMAIN 583..647
FT /note="SAM"
FT /evidence="ECO:0000259|PROSITE:PS50105"
FT DOMAIN 660..718
FT /note="SAM"
FT /evidence="ECO:0000259|PROSITE:PS50105"
FT DOMAIN 743..774
FT /note="SAM"
FT /evidence="ECO:0000259|PROSITE:PS50105"
FT REGION 366..578
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 863..901
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 130..157
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 207..286
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 408..422
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 460..476
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 493..515
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 901 AA; 100949 MW; E0DD002135164B9B CRC64;
MLVELPLGIM ESCLKEKEDT ERAKGVMASD ASHALEAALE QMDGIIAGTK TGADISDGTC
EPGLASPASY MNPFPVLHLV EDLRLALEML DHPQERASLL SQIPGPTAAY IKEWFEDSLS
QVNHHGAASN ETYQERLARL EGDKESLILQ VSVLTDQVEA QGEKIRDLEV CLEGHQVKLN
AAEEMLQQEL LSRTSLETQK LDLMTEVSEL KLKLVGMEKE QREQEEKQRK AEELLQELRH
LKIKVEELEN ERNQYEWKLK ATKAEVAQLQ EQVALKDAEI ERLHSQLSRT AALHSNHAEK
DQEIQRLKMG METLLVANED KDRRIEELTG LLNQYRRVKE IVMVTQGPSE RTLSINEEEL
EGSFRKWNTA NKGPEDLFKP EMPPRCSSPT VGPPPLPQKS LETRAQKKLS CSLEDLRSES
VDKSVDGNQL SPVVEPKDSP FLVEHKYPTL PGKLSGATPN GEAAKSTSTA SQPDPAGSSL
LKLRDTESGW DDTAMANDLS STSSGTESGP QSPLTPDGKR SPKGIKKFWG KIRRTQSGNF
NTDAPGMAEF RRGGLRATAG PRLSRTRDSK GQKSDANAPF AQWSTERVCT WLEDFGLGQY
VIFARQWVTS GHTLLTATPQ DMEKELGIKH PLHRKKLVLA VKAINTKQEE KSALLDHIWV
TRWLDDIGLP QYKDQFHESR VDGRMLQYLT VNDLLFLKVT SQLHHLSIKC AIHVLHVNKF
NPHCLHRRPA DESNLSPSEV VQWSNHRVME WLRSVDLAEY APNLRGSGVH GGLIILEPRF
TGDTLAMLLN IPPQKTLLRR HLTTKFNALI GPEAEQEKRE KMTSPAYTPL TTTAKVRPRK
LGFSHFGNIR KKKFDESTDY ICPMEPSDST GDSHRVYSGY RGLSPLDAPE LDGLDQVGQI
S
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