ID A0A3Q2HV30_HORSE Unreviewed; 1041 AA.
AC A0A3Q2HV30;
DT 10-APR-2019, integrated into UniProtKB/TrEMBL.
DT 10-APR-2019, sequence version 1.
DT 27-MAR-2024, entry version 24.
DE SubName: Full=SMC5-SMC6 complex localization factor 1 {ECO:0000313|Ensembl:ENSECAP00000037181.1};
GN Name=SLF1 {ECO:0000313|Ensembl:ENSECAP00000037181.1,
GN ECO:0000313|VGNC:VGNC:23295};
OS Equus caballus (Horse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Perissodactyla; Equidae; Equus.
OX NCBI_TaxID=9796 {ECO:0000313|Ensembl:ENSECAP00000037181.1, ECO:0000313|Proteomes:UP000002281};
RN [1] {ECO:0000313|Ensembl:ENSECAP00000037181.1, ECO:0000313|Proteomes:UP000002281}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Thoroughbred {ECO:0000313|Ensembl:ENSECAP00000037181.1,
RC ECO:0000313|Proteomes:UP000002281};
RX PubMed=19892987; DOI=10.1126/science.1178158;
RG Broad Institute Genome Sequencing Platform;
RG Broad Institute Whole Genome Assembly Team;
RA Wade C.M., Giulotto E., Sigurdsson S., Zoli M., Gnerre S., Imsland F.,
RA Lear T.L., Adelson D.L., Bailey E., Bellone R.R., Bloecker H., Distl O.,
RA Edgar R.C., Garber M., Leeb T., Mauceli E., MacLeod J.N., Penedo M.C.T.,
RA Raison J.M., Sharpe T., Vogel J., Andersson L., Antczak D.F., Biagi T.,
RA Binns M.M., Chowdhary B.P., Coleman S.J., Della Valle G., Fryc S.,
RA Guerin G., Hasegawa T., Hill E.W., Jurka J., Kiialainen A., Lindgren G.,
RA Liu J., Magnani E., Mickelson J.R., Murray J., Nergadze S.G., Onofrio R.,
RA Pedroni S., Piras M.F., Raudsepp T., Rocchi M., Roeed K.H., Ryder O.A.,
RA Searle S., Skow L., Swinburne J.E., Syvaenen A.C., Tozaki T., Valberg S.J.,
RA Vaudin M., White J.R., Zody M.C., Lander E.S., Lindblad-Toh K.;
RT "Genome sequence, comparative analysis, and population genetics of the
RT domestic horse.";
RL Science 326:865-867(2009).
RN [2] {ECO:0000313|Ensembl:ENSECAP00000037181.1}
RP IDENTIFICATION.
RC STRAIN=Thoroughbred {ECO:0000313|Ensembl:ENSECAP00000037181.1};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR AlphaFoldDB; A0A3Q2HV30; -.
DR Ensembl; ENSECAT00000046024.2; ENSECAP00000037181.1; ENSECAG00000015790.3.
DR VGNC; VGNC:23295; SLF1.
DR GeneTree; ENSGT00940000158953; -.
DR Proteomes; UP000002281; Chromosome 14.
DR Bgee; ENSECAG00000015790; Expressed in brainstem and 23 other cell types or tissues.
DR GO; GO:2000781; P:positive regulation of double-strand break repair; IEA:InterPro.
DR CDD; cd17750; BRCT_SLF1; 1.
DR Gene3D; 1.25.40.20; Ankyrin repeat-containing domain; 1.
DR Gene3D; 3.40.50.10190; BRCT domain; 2.
DR InterPro; IPR002110; Ankyrin_rpt.
DR InterPro; IPR036770; Ankyrin_rpt-contain_sf.
DR InterPro; IPR001357; BRCT_dom.
DR InterPro; IPR036420; BRCT_dom_sf.
DR InterPro; IPR042479; Slf1.
DR PANTHER; PTHR46677; SMC5-SMC6 COMPLEX LOCALIZATION FACTOR PROTEIN 1; 1.
DR PANTHER; PTHR46677:SF1; SMC5-SMC6 COMPLEX LOCALIZATION FACTOR PROTEIN 1; 1.
DR Pfam; PF12796; Ank_2; 1.
DR Pfam; PF16770; RTT107_BRCT_5; 1.
DR SMART; SM00248; ANK; 3.
DR SMART; SM00292; BRCT; 2.
DR SUPFAM; SSF48403; Ankyrin repeat; 1.
DR SUPFAM; SSF52113; BRCT domain; 1.
DR PROSITE; PS50297; ANK_REP_REGION; 2.
DR PROSITE; PS50088; ANK_REPEAT; 3.
PE 4: Predicted;
KW ANK repeat {ECO:0000256|PROSITE-ProRule:PRU00023};
KW Reference proteome {ECO:0000313|Proteomes:UP000002281}.
FT DOMAIN 2..80
FT /note="BRCT"
FT /evidence="ECO:0000259|SMART:SM00292"
FT DOMAIN 121..199
FT /note="BRCT"
FT /evidence="ECO:0000259|SMART:SM00292"
FT REPEAT 789..822
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 823..855
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 857..889
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
SQ SEQUENCE 1041 AA; 118897 MW; 3E5CF11C617ECB63 CRC64;
MEDGAPKHII QMTGFKMEEK EALGKLLLKL DCTFIKSEKY KNCTHLIAER LCKSEKFLAA
CAAGKWVLTK DYIIHSAKSG RWLDETTYEW GYKIEKDSHY SPQMQSAPKR WREELKRTGA
PGAFHRWKVV LLVRADKRSD SLVRVLEAGK ANVILPKSSP SGITHVIASN ARIKAEQEKD
NFKAPFYPIQ YLGDFLLEKE IQNGEDSQTN SVWNKHSNEE KNKDFRKDMR FLEMKGALRE
TTCRTQKEIQ NHDEDVNVSS LLTEHRKKEK FRDSCKDLKF IKVRNALGRH TYGNQKEIKK
KDEGILRSYT LRKKCKKEKG RVSRKDVEHN KIETTLRKQI YRDQKEMKNS IFADHAKESK
TKDIRTDMDI VEIKNALRKH IYRAQVKNAG FPRGVLNLIE SLIEGQFFKE AIEELSSLQA
HYIPPACLLH ALLENVLQDN IDTFSGRYFH ILSALLHLHP PWKSPAMSRY YLELFQCPTC
MKGAWSLIEV LVRSCLFNES FCHQISENII GSKVLHLTLL KFFFNLVESE VRHLSQKLYD
WSDSQSLKIT GKAVLLEIFW SGSETSGLLT KPVNMLLEWT IYSHKEKCKS NDVFKHELAY
LLTGILGAAV DYWIFLGLKM GRNVMRHMSD DLGSYVSLSC DDFSSQELEI FICSFSSSWL
QMFVAEAVFK KLCLQSSISI SSEPLSLQKM VYSYLPALGK TGVLGTGRMQ ISKKIGQRPC
LESQRALLML NGAKQKQVEG LPELPELNLA KCSSSLKRLK KKSEGELSCS KENCPSLVPK
MNFHKTNLKG ETALHRACIN NQVEKLILLL SLPGIDINVK DNAGWTPLHE ACNYGNTVCV
QEILQRCPEV DLLTQVDGVT PLHDALSNGH VEIGKLLLQH GGPVLLQQRN SKGELPLDYV
LSSQIKEELF AVTKIEDTVE NFHAQAEKHF YHQQLEFGSF LLSRMLLNFC SIFDLSSEFL
LAFKGLTHLN ELLMACKNCK ETTSAHTDWL LDLYARNIKT LQKLPNILKE LPDNLKVCPG
VHTEALLVTL EMMCRSVSEF S
//
