ID A0A3Q2HW41_HORSE Unreviewed; 349 AA.
AC A0A3Q2HW41;
DT 10-APR-2019, integrated into UniProtKB/TrEMBL.
DT 13-SEP-2023, sequence version 3.
DT 27-MAR-2024, entry version 22.
DE RecName: Full=Protein NDRG3 {ECO:0000256|ARBA:ARBA00015425};
DE AltName: Full=N-myc downstream-regulated gene 3 protein {ECO:0000256|ARBA:ARBA00030207};
GN Name=NDRG3 {ECO:0000313|Ensembl:ENSECAP00000039582.3,
GN ECO:0000313|VGNC:VGNC:20616};
OS Equus caballus (Horse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Perissodactyla; Equidae; Equus.
OX NCBI_TaxID=9796 {ECO:0000313|Ensembl:ENSECAP00000039582.3, ECO:0000313|Proteomes:UP000002281};
RN [1] {ECO:0000313|Ensembl:ENSECAP00000039582.3, ECO:0000313|Proteomes:UP000002281}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Thoroughbred {ECO:0000313|Ensembl:ENSECAP00000039582.3,
RC ECO:0000313|Proteomes:UP000002281};
RX PubMed=19892987; DOI=10.1126/science.1178158;
RG Broad Institute Genome Sequencing Platform;
RG Broad Institute Whole Genome Assembly Team;
RA Wade C.M., Giulotto E., Sigurdsson S., Zoli M., Gnerre S., Imsland F.,
RA Lear T.L., Adelson D.L., Bailey E., Bellone R.R., Bloecker H., Distl O.,
RA Edgar R.C., Garber M., Leeb T., Mauceli E., MacLeod J.N., Penedo M.C.T.,
RA Raison J.M., Sharpe T., Vogel J., Andersson L., Antczak D.F., Biagi T.,
RA Binns M.M., Chowdhary B.P., Coleman S.J., Della Valle G., Fryc S.,
RA Guerin G., Hasegawa T., Hill E.W., Jurka J., Kiialainen A., Lindgren G.,
RA Liu J., Magnani E., Mickelson J.R., Murray J., Nergadze S.G., Onofrio R.,
RA Pedroni S., Piras M.F., Raudsepp T., Rocchi M., Roeed K.H., Ryder O.A.,
RA Searle S., Skow L., Swinburne J.E., Syvaenen A.C., Tozaki T., Valberg S.J.,
RA Vaudin M., White J.R., Zody M.C., Lander E.S., Lindblad-Toh K.;
RT "Genome sequence, comparative analysis, and population genetics of the
RT domestic horse.";
RL Science 326:865-867(2009).
RN [2] {ECO:0000313|Ensembl:ENSECAP00000039582.3}
RP IDENTIFICATION.
RC STRAIN=Thoroughbred {ECO:0000313|Ensembl:ENSECAP00000039582.3};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the NDRG family.
CC {ECO:0000256|ARBA:ARBA00005598}.
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DR AlphaFoldDB; A0A3Q2HW41; -.
DR Ensembl; ENSECAT00000030115.3; ENSECAP00000039582.3; ENSECAG00000016390.4.
DR CTD; 57446; -.
DR VGNC; VGNC:20616; NDRG3.
DR GeneTree; ENSGT00950000182872; -.
DR OrthoDB; 5352016at2759; -.
DR Proteomes; UP000002281; Chromosome 22.
DR Bgee; ENSECAG00000016390; Expressed in cerebellum and 23 other cell types or tissues.
DR ExpressionAtlas; A0A3Q2HW41; baseline.
DR Gene3D; 3.40.50.1820; alpha/beta hydrolase; 1.
DR InterPro; IPR029058; AB_hydrolase.
DR InterPro; IPR004142; NDRG.
DR PANTHER; PTHR11034; N-MYC DOWNSTREAM REGULATED; 1.
DR PANTHER; PTHR11034:SF20; PROTEIN NDRG3; 1.
DR Pfam; PF03096; Ndr; 1.
DR SUPFAM; SSF53474; alpha/beta-Hydrolases; 1.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000002281}.
FT REGION 302..349
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 302..333
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 334..349
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 349 AA; 38435 MW; B446EDF645AF06A8 CRC64;
MDELQDVQLT EIKPLLNDKN GTRNFQDFDC QEHDIETTHG LIHVTVRGLP KGNRPVILTY
HDIGLNHKSC FNAFFNFEDM QEITQHFAVC HVDAPGQQEG APSFPTGYQY PTMDELAEML
PPILTHLSLK SIVGIGVGAG AYILSKFALN HPELVEGLVL INIDPCAKGW IDWAASKLSG
LTTNVVDIIL AHHFGQEELQ ANLDLIQTYR LHIAQDINQE NLQLFLGSYN GRRDLDIERP
LLGQNDNKSK TLKCSALLVV GDSSPAVEAV MADCGGLPQV VQSSWFFFTV PSASMTRLAR
SRTHSTSSSI GSGESAFSRS VTSNQSDGTQ EFSESPDALD RHHTMEVSC
//
