ID A0A3Q2HWL9_HORSE Unreviewed; 1212 AA.
AC A0A3Q2HWL9;
DT 10-APR-2019, integrated into UniProtKB/TrEMBL.
DT 13-SEP-2023, sequence version 3.
DT 27-MAR-2024, entry version 21.
DE SubName: Full=Jumonji and AT-rich interaction domain containing 2 {ECO:0000313|Ensembl:ENSECAP00000039767.3};
GN Name=JARID2 {ECO:0000313|Ensembl:ENSECAP00000039767.3,
GN ECO:0000313|VGNC:VGNC:58735};
OS Equus caballus (Horse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Perissodactyla; Equidae; Equus.
OX NCBI_TaxID=9796 {ECO:0000313|Ensembl:ENSECAP00000039767.3, ECO:0000313|Proteomes:UP000002281};
RN [1] {ECO:0000313|Ensembl:ENSECAP00000039767.3, ECO:0000313|Proteomes:UP000002281}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Thoroughbred {ECO:0000313|Ensembl:ENSECAP00000039767.3,
RC ECO:0000313|Proteomes:UP000002281};
RX PubMed=19892987; DOI=10.1126/science.1178158;
RG Broad Institute Genome Sequencing Platform;
RG Broad Institute Whole Genome Assembly Team;
RA Wade C.M., Giulotto E., Sigurdsson S., Zoli M., Gnerre S., Imsland F.,
RA Lear T.L., Adelson D.L., Bailey E., Bellone R.R., Bloecker H., Distl O.,
RA Edgar R.C., Garber M., Leeb T., Mauceli E., MacLeod J.N., Penedo M.C.T.,
RA Raison J.M., Sharpe T., Vogel J., Andersson L., Antczak D.F., Biagi T.,
RA Binns M.M., Chowdhary B.P., Coleman S.J., Della Valle G., Fryc S.,
RA Guerin G., Hasegawa T., Hill E.W., Jurka J., Kiialainen A., Lindgren G.,
RA Liu J., Magnani E., Mickelson J.R., Murray J., Nergadze S.G., Onofrio R.,
RA Pedroni S., Piras M.F., Raudsepp T., Rocchi M., Roeed K.H., Ryder O.A.,
RA Searle S., Skow L., Swinburne J.E., Syvaenen A.C., Tozaki T., Valberg S.J.,
RA Vaudin M., White J.R., Zody M.C., Lander E.S., Lindblad-Toh K.;
RT "Genome sequence, comparative analysis, and population genetics of the
RT domestic horse.";
RL Science 326:865-867(2009).
RN [2] {ECO:0000313|Ensembl:ENSECAP00000039767.3}
RP IDENTIFICATION.
RC STRAIN=Thoroughbred {ECO:0000313|Ensembl:ENSECAP00000039767.3};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR Ensembl; ENSECAT00000052096.3; ENSECAP00000039767.3; ENSECAG00000011721.4.
DR VGNC; VGNC:58735; JARID2.
DR GeneTree; ENSGT00940000159220; -.
DR Proteomes; UP000002281; Chromosome 20.
DR Bgee; ENSECAG00000011721; Expressed in inner cell mass and 23 other cell types or tissues.
DR GO; GO:0005634; C:nucleus; IEA:UniProt.
DR GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR GO; GO:0006325; P:chromatin organization; IEA:UniProtKB-KW.
DR CDD; cd16870; ARID_JARD2; 1.
DR Gene3D; 1.10.150.60; ARID DNA-binding domain; 1.
DR Gene3D; 2.60.120.650; Cupin; 1.
DR InterPro; IPR001606; ARID_dom.
DR InterPro; IPR036431; ARID_dom_sf.
DR InterPro; IPR003347; JmjC_dom.
DR InterPro; IPR003349; JmjN.
DR InterPro; IPR004198; Znf_C5HC2.
DR PANTHER; PTHR10694; LYSINE-SPECIFIC DEMETHYLASE; 1.
DR PANTHER; PTHR10694:SF113; PROTEIN JUMONJI; 1.
DR Pfam; PF01388; ARID; 1.
DR Pfam; PF02373; JmjC; 1.
DR Pfam; PF02375; JmjN; 1.
DR Pfam; PF02928; zf-C5HC2; 1.
DR SMART; SM01014; ARID; 1.
DR SMART; SM00501; BRIGHT; 1.
DR SMART; SM00558; JmjC; 1.
DR SMART; SM00545; JmjN; 1.
DR SUPFAM; SSF46774; ARID-like; 1.
DR SUPFAM; SSF51197; Clavaminate synthase-like; 1.
DR PROSITE; PS51011; ARID; 1.
DR PROSITE; PS51184; JMJC; 1.
DR PROSITE; PS51183; JMJN; 1.
PE 4: Predicted;
KW Chromatin regulator {ECO:0000256|ARBA:ARBA00022853};
KW Reference proteome {ECO:0000313|Proteomes:UP000002281}.
FT DOMAIN 523..564
FT /note="JmjN"
FT /evidence="ECO:0000259|PROSITE:PS51183"
FT DOMAIN 587..679
FT /note="ARID"
FT /evidence="ECO:0000259|PROSITE:PS51011"
FT DOMAIN 850..1014
FT /note="JmjC"
FT /evidence="ECO:0000259|PROSITE:PS51184"
FT REGION 23..112
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 131..301
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 319..515
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1174..1212
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 46..61
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 76..92
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 142..156
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 191..226
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 263..283
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 329..361
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 384..411
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 449..467
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 495..509
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1196..1212
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1212 AA; 134336 MW; 7CBCB2A03E7B7BF4 CRC64;
MAAPRVCQVQ FLVAYLEEPG IEGLLGNGQS KGLGPASEQS ENEKDDASQV SSTSNDVSSS
DFEEGPSRKR PRLQAQRKFA QSQPNSPSTT PVKIVEPLLP PPATQISDLS KRKPKTEDFL
TFLCLRGSPA LPNSMVYFGS SQDEEDVEEE DDETEDVKTA TNNASSSCQS TPRKGKTHKH
VHNGHVFNGS SRSSREKEPV QKHKSKEATP GKEKHSDHRA DSRREQASAT HPPAAPSPGS
SAKGLAANHH HPPLHRSAQD LRKQVSKVNG VTRMSSLGTS ATSAKKMREV RPSPSKTVKY
TATVTKGTVT YTKAKRELVK ETKPNHHKPS SAVNHTISGK TESSNAKTRK QVLSLGGASK
STGPAVNGLK VSGRLNPKSC TKEVGGRQLR EGLRNSKRRL EEAHQAEKPQ SPPKKMKGAA
ACAEAPSRKA AAAPALAPAP ADRALLSGPG KKDVPERSAE RTRPKRATAG KSTPGRQAHG
KPDGASCENR STSQSETLHK PHETSARPEK GGGRAGWAAM DEIPVLRPSA KEFHDPLVYI
ESVRAQVEKY GMCRVIPPPD WRPECKLNDE MRFVTQIQHI HKLGRRWGPN VQRLACIKKH
LRSQGITMDE LPLIGGCELD LACFFRLINE MGGMQQVTDL KKWNKLADML RIPKTAQDRL
AKLQEAYCQY LLSYDSLSPE EHRRLEKEVL MEKEILEKRK GPLEGHTEHD YNKFHPLPRF
EPKNGLINGV AHRNGFRSKL KEVGQAQLKT GRRRLFAQEK EVVKEEEEDK GVLSDFHKCI
YKGRSVSLTT FYRTARNIMN MCFSKEPAPA EIEQEYWRLV EEKDCHVAVH CGKVDTNTHG
SGFPVGKSEP FSRHGWNLTV LPNNTGSILR HLGAVPGVTI PWLNIGMVFS TSCWSRDQNH
LPYIDYLHTG ADCIWYCIPA EEESKLEDVV HTLLQANGTP GLQMLESNVM ISPEVLCKEG
IKVHRTVQQS GQFVVCFPGS FVSKVCCGYS VSETVHFATT QWTSMGFETA KEMKRRHIAK
PFSMEKLLYQ IAQAEAKKEN GPTLSTISAL LDELRDTELR QRRQLFEAGL HSSARYGSHD
GSSTVADGKK KPRKWLQLET SERRCQICQH LCYLSMVVQE NENVVFCLEC ALRHVEKQKS
CRGLKLMYRY DEEQIISLVN QICGKVSGKN GSIENCLSKP TPKRGPRKRA TVDVPPARLS
SSSAAKSASS SS
//
