ID A0A3Q2HWU0_HORSE Unreviewed; 930 AA.
AC A0A3Q2HWU0;
DT 10-APR-2019, integrated into UniProtKB/TrEMBL.
DT 13-SEP-2023, sequence version 3.
DT 27-MAR-2024, entry version 27.
DE SubName: Full=Rho guanine nucleotide exchange factor 1 {ECO:0000313|Ensembl:ENSECAP00000038909.3};
GN Name=ARHGEF1 {ECO:0000313|Ensembl:ENSECAP00000038909.3,
GN ECO:0000313|VGNC:VGNC:112201};
OS Equus caballus (Horse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Perissodactyla; Equidae; Equus.
OX NCBI_TaxID=9796 {ECO:0000313|Ensembl:ENSECAP00000038909.3, ECO:0000313|Proteomes:UP000002281};
RN [1] {ECO:0000313|Ensembl:ENSECAP00000038909.3, ECO:0000313|Proteomes:UP000002281}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Thoroughbred {ECO:0000313|Ensembl:ENSECAP00000038909.3,
RC ECO:0000313|Proteomes:UP000002281};
RX PubMed=19892987; DOI=10.1126/science.1178158;
RG Broad Institute Genome Sequencing Platform;
RG Broad Institute Whole Genome Assembly Team;
RA Wade C.M., Giulotto E., Sigurdsson S., Zoli M., Gnerre S., Imsland F.,
RA Lear T.L., Adelson D.L., Bailey E., Bellone R.R., Bloecker H., Distl O.,
RA Edgar R.C., Garber M., Leeb T., Mauceli E., MacLeod J.N., Penedo M.C.T.,
RA Raison J.M., Sharpe T., Vogel J., Andersson L., Antczak D.F., Biagi T.,
RA Binns M.M., Chowdhary B.P., Coleman S.J., Della Valle G., Fryc S.,
RA Guerin G., Hasegawa T., Hill E.W., Jurka J., Kiialainen A., Lindgren G.,
RA Liu J., Magnani E., Mickelson J.R., Murray J., Nergadze S.G., Onofrio R.,
RA Pedroni S., Piras M.F., Raudsepp T., Rocchi M., Roeed K.H., Ryder O.A.,
RA Searle S., Skow L., Swinburne J.E., Syvaenen A.C., Tozaki T., Valberg S.J.,
RA Vaudin M., White J.R., Zody M.C., Lander E.S., Lindblad-Toh K.;
RT "Genome sequence, comparative analysis, and population genetics of the
RT domestic horse.";
RL Science 326:865-867(2009).
RN [2] {ECO:0000313|Ensembl:ENSECAP00000038909.3}
RP IDENTIFICATION.
RC STRAIN=Thoroughbred {ECO:0000313|Ensembl:ENSECAP00000038909.3};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
CC Membrane {ECO:0000256|ARBA:ARBA00004370}.
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DR AlphaFoldDB; A0A3Q2HWU0; -.
DR Ensembl; ENSECAT00000041402.3; ENSECAP00000038909.3; ENSECAG00000035888.3.
DR VGNC; VGNC:112201; ARHGEF1.
DR GeneTree; ENSGT00940000161180; -.
DR Proteomes; UP000002281; Chromosome 10.
DR Bgee; ENSECAG00000035888; Expressed in leukocyte and 23 other cell types or tissues.
DR ExpressionAtlas; A0A3Q2HWU0; baseline.
DR GO; GO:0005737; C:cytoplasm; IEA:InterPro.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0001664; F:G protein-coupled receptor binding; IEA:InterPro.
DR GO; GO:0005096; F:GTPase activator activity; IEA:InterPro.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:InterPro.
DR GO; GO:0007186; P:G protein-coupled receptor signaling pathway; IEA:InterPro.
DR CDD; cd14679; PH_p115RhoGEF; 1.
DR CDD; cd08755; RGS_p115RhoGEF; 1.
DR CDD; cd00160; RhoGEF; 1.
DR Gene3D; 1.20.900.10; Dbl homology (DH) domain; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR Gene3D; 1.10.167.10; Regulator of G-protein Signalling 4, domain 2; 1.
DR InterPro; IPR035899; DBL_dom_sf.
DR InterPro; IPR000219; DH-domain.
DR InterPro; IPR037887; p115RhoGEF_RGS.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR041020; PH_16.
DR InterPro; IPR001849; PH_domain.
DR InterPro; IPR015212; RGS-like_dom.
DR InterPro; IPR036305; RGS_sf.
DR InterPro; IPR044926; RGS_subdomain_2.
DR PANTHER; PTHR45872:SF4; RHO GUANINE NUCLEOTIDE EXCHANGE FACTOR 1; 1.
DR PANTHER; PTHR45872; RHO GUANINE NUCLEOTIDE EXCHANGE FACTOR 2, ISOFORM D; 1.
DR Pfam; PF17838; PH_16; 1.
DR Pfam; PF09128; RGS-like; 1.
DR Pfam; PF00621; RhoGEF; 1.
DR SMART; SM00233; PH; 1.
DR SMART; SM00325; RhoGEF; 1.
DR SUPFAM; SSF48065; DBL homology domain (DH-domain); 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR SUPFAM; SSF48097; Regulator of G-protein signaling, RGS; 1.
DR PROSITE; PS50010; DH_2; 1.
DR PROSITE; PS50003; PH_DOMAIN; 1.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054};
KW Membrane {ECO:0000256|ARBA:ARBA00023136};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000002281}.
FT DOMAIN 434..623
FT /note="DH"
FT /evidence="ECO:0000259|PROSITE:PS50010"
FT DOMAIN 665..778
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT REGION 1..45
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 298..417
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 783..818
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 860..883
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..20
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 298..315
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 396..416
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 930 AA; 104375 MW; 1606C97CDE630F40 CRC64;
MRRGALKGQT DRRPAEPMEA EDVARGAAPG PHRPGPVPVS IIGAEDEDFE NELETNTEEQ
NSQFQSLEQV KRRPVHLMAL LQHVALQFDP GPLLCCLHAD MLGSLGPKEA KKAFIDFYHS
FLDKTAVLRV VVPPTVSFEL DRTRPDLLSE DVQRQFVQEV VQSQQEAVSR QLEDFRSKRL
MGMTPSEQEL SQLEAWVGRD RASFEARERH VAEQLLNHLE EIQHTISTDE EKSAAVVSAI
SLYMRHLGVR TKSGDKKSGR NFFRKKVMGN KRSDEPTKTK KGLSSFLDAA RWNRVEPQVP
DMRHLKNETN VEKLGLTERK GGLGAPSRDR NVGAPGQDTP GVSVHPLSGD SPNRESGVDG
PLELGDPPSQ GPASLELPAP PESTEEGADT ESPEPGDEGE PGRSGLELEP EEPPGWRELI
LPDTLHSLPK SQVKRQEVIS ELLVTEAAHV RMLRVLHDLF YQPMVDGGFF PVEELQNIFP
SLDELIEVHS LFLDCLMKRR QDSGPVIEEI GDVLLARFDG AEGSWFQKIS SRFCSRQSFA
LEQLKAKQRK EPRFSAFVQE AESRPRCRRL QLKDMIPTEM QRLTKYPLLL QSIGQNTEEP
AEREKVELAA ECCREILHHV NQAVRDMEDL LRLKDYQRRL DLSHLRQSSD PMLSEFKNLD
ITKKRLIHEG PLTWRVTKDK AVEVHVLLLD DLLLLLQRQD ERLLLKSHSR TLTPTPDGKT
MLRPVLRLTS AMTREVATDH KAFYVIFTWD QEAQIYELVA QTVSERKNWC NLITETAGSL
KVPAPASRHK PRPSPISTRE PLLSSSENGN CGREMPPADG RMERLLSALL PFSRLGPEGQ
LAAKALGKVL SLKQLLFPME EDSGAGPPRA GDGVPGGGPL SPAQTQEIRE ELLSLEETIK
QLEEVEEEFC RLRVLLSQLG ENTVPQPGCT
//
