ID A0A3Q2HWV7_HORSE Unreviewed; 754 AA.
AC A0A3Q2HWV7;
DT 10-APR-2019, integrated into UniProtKB/TrEMBL.
DT 10-APR-2019, sequence version 1.
DT 27-MAR-2024, entry version 24.
DE SubName: Full=Mitotic arrest deficient 1 like 1 {ECO:0000313|Ensembl:ENSECAP00000039868.1};
GN Name=MAD1L1 {ECO:0000313|Ensembl:ENSECAP00000039868.1,
GN ECO:0000313|VGNC:VGNC:19883};
OS Equus caballus (Horse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Perissodactyla; Equidae; Equus.
OX NCBI_TaxID=9796 {ECO:0000313|Ensembl:ENSECAP00000039868.1, ECO:0000313|Proteomes:UP000002281};
RN [1] {ECO:0000313|Ensembl:ENSECAP00000039868.1, ECO:0000313|Proteomes:UP000002281}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Thoroughbred {ECO:0000313|Ensembl:ENSECAP00000039868.1,
RC ECO:0000313|Proteomes:UP000002281};
RX PubMed=19892987; DOI=10.1126/science.1178158;
RG Broad Institute Genome Sequencing Platform;
RG Broad Institute Whole Genome Assembly Team;
RA Wade C.M., Giulotto E., Sigurdsson S., Zoli M., Gnerre S., Imsland F.,
RA Lear T.L., Adelson D.L., Bailey E., Bellone R.R., Bloecker H., Distl O.,
RA Edgar R.C., Garber M., Leeb T., Mauceli E., MacLeod J.N., Penedo M.C.T.,
RA Raison J.M., Sharpe T., Vogel J., Andersson L., Antczak D.F., Biagi T.,
RA Binns M.M., Chowdhary B.P., Coleman S.J., Della Valle G., Fryc S.,
RA Guerin G., Hasegawa T., Hill E.W., Jurka J., Kiialainen A., Lindgren G.,
RA Liu J., Magnani E., Mickelson J.R., Murray J., Nergadze S.G., Onofrio R.,
RA Pedroni S., Piras M.F., Raudsepp T., Rocchi M., Roeed K.H., Ryder O.A.,
RA Searle S., Skow L., Swinburne J.E., Syvaenen A.C., Tozaki T., Valberg S.J.,
RA Vaudin M., White J.R., Zody M.C., Lander E.S., Lindblad-Toh K.;
RT "Genome sequence, comparative analysis, and population genetics of the
RT domestic horse.";
RL Science 326:865-867(2009).
RN [2] {ECO:0000313|Ensembl:ENSECAP00000039868.1}
RP IDENTIFICATION.
RC STRAIN=Thoroughbred {ECO:0000313|Ensembl:ENSECAP00000039868.1};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the MAD1 family.
CC {ECO:0000256|ARBA:ARBA00008029}.
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DR RefSeq; XP_014585303.1; XM_014729817.1.
DR AlphaFoldDB; A0A3Q2HWV7; -.
DR SMR; A0A3Q2HWV7; -.
DR STRING; 9796.ENSECAP00000039868; -.
DR PaxDb; 9796-ENSECAP00000039868; -.
DR Ensembl; ENSECAT00000044802.2; ENSECAP00000039868.1; ENSECAG00000014242.4.
DR VGNC; VGNC:19883; MAD1L1.
DR GeneTree; ENSGT00390000001316; -.
DR InParanoid; A0A3Q2HWV7; -.
DR OMA; YKLDFMP; -.
DR Proteomes; UP000002281; Chromosome 13.
DR Bgee; ENSECAG00000014242; Expressed in articular cartilage of joint and 22 other cell types or tissues.
DR GO; GO:0000776; C:kinetochore; IBA:GO_Central.
DR GO; GO:1990706; C:MAD1 complex; IEA:Ensembl.
DR GO; GO:0072686; C:mitotic spindle; IBA:GO_Central.
DR GO; GO:1990728; C:mitotic spindle assembly checkpoint MAD1-MAD2 complex; IEA:Ensembl.
DR GO; GO:0097431; C:mitotic spindle pole; IEA:Ensembl.
DR GO; GO:0005635; C:nuclear envelope; IBA:GO_Central.
DR GO; GO:0044615; C:nuclear pore nuclear basket; IEA:Ensembl.
DR GO; GO:0042802; F:identical protein binding; IEA:Ensembl.
DR GO; GO:0043515; F:kinetochore binding; IEA:Ensembl.
DR GO; GO:0051315; P:attachment of mitotic spindle microtubules to kinetochore; IBA:GO_Central.
DR GO; GO:0007094; P:mitotic spindle assembly checkpoint signaling; IBA:GO_Central.
DR GO; GO:0042130; P:negative regulation of T cell proliferation; IEA:Ensembl.
DR GO; GO:0090267; P:positive regulation of mitotic cell cycle spindle assembly checkpoint; IEA:Ensembl.
DR GO; GO:0090235; P:regulation of metaphase plate congression; IEA:Ensembl.
DR GO; GO:0048538; P:thymus development; IEA:Ensembl.
DR Gene3D; 1.20.5.170; -; 1.
DR Gene3D; 3.30.457.60; -; 1.
DR Gene3D; 6.10.250.90; -; 1.
DR InterPro; IPR008672; Mad1.
DR PANTHER; PTHR23168:SF0; MITOTIC SPINDLE ASSEMBLY CHECKPOINT PROTEIN MAD1; 1.
DR PANTHER; PTHR23168; MITOTIC SPINDLE ASSEMBLY CHECKPOINT PROTEIN MAD1 MITOTIC ARREST DEFICIENT-LIKE PROTEIN 1; 1.
DR Pfam; PF05557; MAD; 2.
DR SUPFAM; SSF75704; Mitotic arrest deficient-like 1, Mad1; 1.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000002281}.
FT REGION 412..441
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 41..131
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 173..320
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 359..400
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 493..664
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 754 AA; 87297 MW; 409854558AE0BF18 CRC64;
MEDLGENTTV LSTLRSLNNF ISQRVEGGSG LDVSTSAQGS LQMQYQQSMQ LEERAEQIRS
KSHLIQMERE KMQMELSHKR ARVELERAAS TSARSYEREV DRNQELLTRI RQLQEREAEV
EEKMKEQQER SRLCKQSLDV ASKKLREKED GLAEAGETIS ALKGRVSELQ WSVMNQEMQV
RSLESEKQEL KEQLDLQHKK WQEANQKIQE LQASQEVRAD QEQRIKDLEQ KLSLQEQDAV
IVKNMKSELV RLPKMERELK QLREENVHLR EMRETNGLLR EELEGLRRKL GRQEKMQENL
VDLELEKERL LAKLQSWERL DQTTGLSIRT PEDLSRFIVE LQQRELALKD RNSSITCSAR
GLEKVRQQLQ EEVRQVSSQL LEERKRRETH EALARRLQKR VLLLTKKPVR SSRRSRCHLH
RRRGAQEGEA PAGAEGAAGP RCRERDGMRA ILGSYDSELT PAEYSPQLTR RMREAEDMVQ
KVHAHSSEME AQLSQALEEL GGQKQRADML EMELKMLKSQ SGPADQSFLF SREEVNSLRS
KVEELEGARS RLEEDKKMLE MRLERLTLQG DYDPSRTKVL HLRMNPASAA RQHQHEEHAQ
LQEECERLRE LVRALERGGP VPAGLEATAA LPSSKEVTEL RKQVESAELK NQRLKEVFQT
KIQEFRKACY ALTGYQIDVT AESQYRLTSL YAEHKADCLV FKATGPSGSK MQLLETEFSR
TVQELIELHL LRQDSIPAFL SALTLDLFSR QTVA
//
