ID A0A3Q2HX84_HORSE Unreviewed; 632 AA.
AC A0A3Q2HX84;
DT 10-APR-2019, integrated into UniProtKB/TrEMBL.
DT 10-APR-2019, sequence version 1.
DT 27-MAR-2024, entry version 19.
DE SubName: Full=CD6 molecule {ECO:0000313|Ensembl:ENSECAP00000039811.1};
GN Name=CD6 {ECO:0000313|Ensembl:ENSECAP00000039811.1,
GN ECO:0000313|VGNC:VGNC:16274};
OS Equus caballus (Horse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Perissodactyla; Equidae; Equus.
OX NCBI_TaxID=9796 {ECO:0000313|Ensembl:ENSECAP00000039811.1, ECO:0000313|Proteomes:UP000002281};
RN [1] {ECO:0000313|Ensembl:ENSECAP00000039811.1, ECO:0000313|Proteomes:UP000002281}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Thoroughbred {ECO:0000313|Ensembl:ENSECAP00000039811.1,
RC ECO:0000313|Proteomes:UP000002281};
RX PubMed=19892987; DOI=10.1126/science.1178158;
RG Broad Institute Genome Sequencing Platform;
RG Broad Institute Whole Genome Assembly Team;
RA Wade C.M., Giulotto E., Sigurdsson S., Zoli M., Gnerre S., Imsland F.,
RA Lear T.L., Adelson D.L., Bailey E., Bellone R.R., Bloecker H., Distl O.,
RA Edgar R.C., Garber M., Leeb T., Mauceli E., MacLeod J.N., Penedo M.C.T.,
RA Raison J.M., Sharpe T., Vogel J., Andersson L., Antczak D.F., Biagi T.,
RA Binns M.M., Chowdhary B.P., Coleman S.J., Della Valle G., Fryc S.,
RA Guerin G., Hasegawa T., Hill E.W., Jurka J., Kiialainen A., Lindgren G.,
RA Liu J., Magnani E., Mickelson J.R., Murray J., Nergadze S.G., Onofrio R.,
RA Pedroni S., Piras M.F., Raudsepp T., Rocchi M., Roeed K.H., Ryder O.A.,
RA Searle S., Skow L., Swinburne J.E., Syvaenen A.C., Tozaki T., Valberg S.J.,
RA Vaudin M., White J.R., Zody M.C., Lander E.S., Lindblad-Toh K.;
RT "Genome sequence, comparative analysis, and population genetics of the
RT domestic horse.";
RL Science 326:865-867(2009).
RN [2] {ECO:0000313|Ensembl:ENSECAP00000039811.1}
RP IDENTIFICATION.
RC STRAIN=Thoroughbred {ECO:0000313|Ensembl:ENSECAP00000039811.1};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00196}.
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DR AlphaFoldDB; A0A3Q2HX84; -.
DR Ensembl; ENSECAT00000058239.3; ENSECAP00000039811.1; ENSECAG00000011180.4.
DR VGNC; VGNC:16274; CD6.
DR GeneTree; ENSGT00940000161029; -.
DR Proteomes; UP000002281; Chromosome 12.
DR Bgee; ENSECAG00000011180; Expressed in leukocyte and 17 other cell types or tissues.
DR ExpressionAtlas; A0A3Q2HX84; baseline.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR Gene3D; 3.10.250.10; SRCR-like domain; 3.
DR InterPro; IPR001190; SRCR.
DR InterPro; IPR017448; SRCR-like_dom.
DR InterPro; IPR036772; SRCR-like_dom_sf.
DR PANTHER; PTHR19331; SCAVENGER RECEPTOR DOMAIN-CONTAINING; 1.
DR PANTHER; PTHR19331:SF477; T-CELL DIFFERENTIATION ANTIGEN CD6; 1.
DR Pfam; PF00530; SRCR; 3.
DR PRINTS; PR00258; SPERACTRCPTR.
DR SMART; SM00202; SR; 3.
DR SUPFAM; SSF56487; SRCR-like; 3.
DR PROSITE; PS50287; SRCR_2; 3.
PE 4: Predicted;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157, ECO:0000256|PROSITE-
KW ProRule:PRU00196}; Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000002281};
KW Signal {ECO:0000256|SAM:SignalP}; Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..21
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 22..632
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5018746721"
FT TRANSMEM 404..429
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 49..160
FT /note="SRCR"
FT /evidence="ECO:0000259|PROSITE:PS50287"
FT DOMAIN 165..264
FT /note="SRCR"
FT /evidence="ECO:0000259|PROSITE:PS50287"
FT DOMAIN 269..366
FT /note="SRCR"
FT /evidence="ECO:0000259|PROSITE:PS50287"
FT REGION 101..124
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 495..543
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 556..632
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 522..543
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 568..596
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 597..612
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT DISULFID 234..244
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00196"
FT DISULFID 335..345
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00196"
SQ SEQUENCE 632 AA; 67534 MW; 89ED8BBD347012E2 CRC64;
MAPDMWFFLV IAGWLMPTLS GDPSPTPSGL PNTSSAQSQT LEPGALLRVR LANGSSRCSG
TVEVRLGAAW EPVCGAPWDR RAAEAVCRAL GCGRPGATVQ PATLPPELPP GPAAGNASGA
PNATQAPAPA VLCNGTEWRL CEVVEGACSR DARPAQVTCS ENPELRLVDG GSPCAGRVEM
LEDGQWGSVC DDTWDLEDAH VVCRQLSCGW AIQALPGLHF APGQGPIHRD QVNCSGAESY
LQDCPGQPGH GYCGHKEDAG VVCSEHQSWR LTGGTDSCEG QVEVHFRGVW NTVCDSEWYS
EEATVLCRAL GCGTAAARVP KGLPHSLSGR MYYSCEGTEP TLSDCFWRFN NSNLCRQSQA
ARVLCSGSRS LLNLSSSEAP TSVQPLTVES SVMVNTEDWE SRELMLLILC IVLGVLLLGS
FITIAFIFLK VKGKYALPVM ANHEHLPTTT PAGINSYQDV PVTISTKEDS QRHRPTDEEI
QQSRFQMPPL EEGLEEMHAS QVPPANSGHC IADAPSLGPQ HHPRTKSGSS TSSGEGYCNN
PSGRLPLWNP QAFSAEKTPF LEPPPNLELA GSQTTFSAGR SADDSSSTSS GEWYQNFQPP
PQPPPKEQLE YPAPPSPQSE STSEDYDDIG AA
//
