ID A0A3Q2HZL3_HORSE Unreviewed; 605 AA.
AC A0A3Q2HZL3;
DT 10-APR-2019, integrated into UniProtKB/TrEMBL.
DT 13-SEP-2023, sequence version 3.
DT 27-MAR-2024, entry version 27.
DE SubName: Full=EBF transcription factor 1 {ECO:0000313|Ensembl:ENSECAP00000040743.3};
GN Name=EBF1 {ECO:0000313|Ensembl:ENSECAP00000040743.3,
GN ECO:0000313|VGNC:VGNC:17396};
OS Equus caballus (Horse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Perissodactyla; Equidae; Equus.
OX NCBI_TaxID=9796 {ECO:0000313|Ensembl:ENSECAP00000040743.3, ECO:0000313|Proteomes:UP000002281};
RN [1] {ECO:0000313|Ensembl:ENSECAP00000040743.3, ECO:0000313|Proteomes:UP000002281}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Thoroughbred {ECO:0000313|Ensembl:ENSECAP00000040743.3,
RC ECO:0000313|Proteomes:UP000002281};
RX PubMed=19892987; DOI=10.1126/science.1178158;
RG Broad Institute Genome Sequencing Platform;
RG Broad Institute Whole Genome Assembly Team;
RA Wade C.M., Giulotto E., Sigurdsson S., Zoli M., Gnerre S., Imsland F.,
RA Lear T.L., Adelson D.L., Bailey E., Bellone R.R., Bloecker H., Distl O.,
RA Edgar R.C., Garber M., Leeb T., Mauceli E., MacLeod J.N., Penedo M.C.T.,
RA Raison J.M., Sharpe T., Vogel J., Andersson L., Antczak D.F., Biagi T.,
RA Binns M.M., Chowdhary B.P., Coleman S.J., Della Valle G., Fryc S.,
RA Guerin G., Hasegawa T., Hill E.W., Jurka J., Kiialainen A., Lindgren G.,
RA Liu J., Magnani E., Mickelson J.R., Murray J., Nergadze S.G., Onofrio R.,
RA Pedroni S., Piras M.F., Raudsepp T., Rocchi M., Roeed K.H., Ryder O.A.,
RA Searle S., Skow L., Swinburne J.E., Syvaenen A.C., Tozaki T., Valberg S.J.,
RA Vaudin M., White J.R., Zody M.C., Lander E.S., Lindblad-Toh K.;
RT "Genome sequence, comparative analysis, and population genetics of the
RT domestic horse.";
RL Science 326:865-867(2009).
RN [2] {ECO:0000313|Ensembl:ENSECAP00000040743.3}
RP IDENTIFICATION.
RC STRAIN=Thoroughbred {ECO:0000313|Ensembl:ENSECAP00000040743.3};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123,
CC ECO:0000256|RuleBase:RU004489}.
CC -!- SIMILARITY: Belongs to the COE family. {ECO:0000256|ARBA:ARBA00010340,
CC ECO:0000256|RuleBase:RU004489}.
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DR AlphaFoldDB; A0A3Q2HZL3; -.
DR STRING; 9796.ENSECAP00000040743; -.
DR PaxDb; 9796-ENSECAP00000040743; -.
DR Ensembl; ENSECAT00000046220.3; ENSECAP00000040743.3; ENSECAG00000007964.5.
DR CTD; 1879; -.
DR VGNC; VGNC:17396; EBF1.
DR GeneTree; ENSGT00950000182859; -.
DR InParanoid; A0A3Q2HZL3; -.
DR OMA; LMIPRCL; -.
DR OrthoDB; 3641706at2759; -.
DR Proteomes; UP000002281; Chromosome 14.
DR Bgee; ENSECAG00000007964; Expressed in synovial membrane of synovial joint and 21 other cell types or tissues.
DR ExpressionAtlas; A0A3Q2HZL3; baseline.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR CDD; cd11606; COE_DBD; 1.
DR CDD; cd01175; IPT_COE; 1.
DR Gene3D; 1.10.287.4280; -; 1.
DR Gene3D; 2.60.40.10; Immunoglobulins; 1.
DR Gene3D; 2.60.40.3180; Transcription factor COE1, DNA-binding domain; 1.
DR InterPro; IPR032200; COE_DBD.
DR InterPro; IPR038173; COE_DBD_sf.
DR InterPro; IPR032201; COE_HLH.
DR InterPro; IPR038006; COE_IPT.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR014756; Ig_E-set.
DR InterPro; IPR002909; IPT_dom.
DR InterPro; IPR003523; Transcription_factor_COE.
DR InterPro; IPR018350; Transcription_factor_COE_CS.
DR PANTHER; PTHR10747; TRANSCRIPTION FACTOR COE FAMILY MEMBER; 1.
DR PANTHER; PTHR10747:SF26; TRANSCRIPTION FACTOR COE1; 1.
DR Pfam; PF16422; COE1_DBD; 1.
DR Pfam; PF16423; COE1_HLH; 1.
DR Pfam; PF01833; TIG; 1.
DR SMART; SM00429; IPT; 1.
DR SUPFAM; SSF81296; E set domains; 1.
DR PROSITE; PS01345; COE; 1.
PE 3: Inferred from homology;
KW Developmental protein {ECO:0000256|RuleBase:RU004489};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|RuleBase:RU004489};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723,
KW ECO:0000256|RuleBase:RU004489};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242, ECO:0000256|RuleBase:RU004489};
KW Reference proteome {ECO:0000313|Proteomes:UP000002281};
KW Transcription {ECO:0000256|ARBA:ARBA00023163,
KW ECO:0000256|RuleBase:RU004489};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015,
KW ECO:0000256|RuleBase:RU004489};
KW Zinc {ECO:0000256|ARBA:ARBA00022833, ECO:0000256|RuleBase:RU004489};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|RuleBase:RU004489}.
FT DOMAIN 275..359
FT /note="IPT/TIG"
FT /evidence="ECO:0000259|SMART:SM00429"
FT REGION 1..34
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 471..495
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 605 AA; 65957 MW; 5D8210AA2220C167 CRC64;
MQMRGRVCQA RAPPPPFGES IQRSGSSMKE EPLGSGMNAV RTWMQGAGVL DANTAAQSGV
GLARAHFEKQ PPSNLRKSNF FHFVLALYDR QGQPVEIERT AFVGFVEKEK EANSEKTNNG
IHYRLQLLYS NGIRTEQDFY VRLIDSMTKQ AIVYEGQDKN PEMCRVLLTH EIMCSRCCDK
KSCGNRNETP SDPVIIDRFF LKFFLKCNQN CLKNAGNPRD MRRFQVVVST TVNVDGHVLA
VSDNMFVHNN SKHGRRARRL DPSEGTPSYL EHAATPCIKA ISPSEGWTTG GATVIIIGDN
FFDGLQVIFG TMLVWSELIT PHAIRVQTPP RHIPGVVEVT LSYKSKQFCK GTPGRFIYTA
LNEPTIDYGF QRLQKVIPRH PGDPERLPKE VILKRAADLV EALYGMPHNN QEIILKRAAD
IAEALYSVPR NHSQLPALTN TSVHAGMMGV NSFSGQLAVN VSEASQATNQ GFTRNSSSVS
PHGYVPSTTP QQTNYNSVTT SMNGYGTAAM SNLGGSPTFL NGSAANSPYA IVPSSPTMAS
STSLPSNCSS SSGIFSFSPA NMVSAVKQKS AFAPVVRPQT SPPPTCTSTN GNSLQAISGM
IVPPM
//
