ID A0A3Q2I0C5_HORSE Unreviewed; 634 AA.
AC A0A3Q2I0C5;
DT 10-APR-2019, integrated into UniProtKB/TrEMBL.
DT 13-SEP-2023, sequence version 2.
DT 27-MAR-2024, entry version 23.
DE SubName: Full=Septin 9 {ECO:0000313|Ensembl:ENSECAP00000040386.2};
GN Name=SEPTIN9 {ECO:0000313|Ensembl:ENSECAP00000040386.2,
GN ECO:0000313|VGNC:VGNC:22836};
OS Equus caballus (Horse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Perissodactyla; Equidae; Equus.
OX NCBI_TaxID=9796 {ECO:0000313|Ensembl:ENSECAP00000040386.2, ECO:0000313|Proteomes:UP000002281};
RN [1] {ECO:0000313|Ensembl:ENSECAP00000040386.2, ECO:0000313|Proteomes:UP000002281}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Thoroughbred {ECO:0000313|Ensembl:ENSECAP00000040386.2,
RC ECO:0000313|Proteomes:UP000002281};
RX PubMed=19892987; DOI=10.1126/science.1178158;
RG Broad Institute Genome Sequencing Platform;
RG Broad Institute Whole Genome Assembly Team;
RA Wade C.M., Giulotto E., Sigurdsson S., Zoli M., Gnerre S., Imsland F.,
RA Lear T.L., Adelson D.L., Bailey E., Bellone R.R., Bloecker H., Distl O.,
RA Edgar R.C., Garber M., Leeb T., Mauceli E., MacLeod J.N., Penedo M.C.T.,
RA Raison J.M., Sharpe T., Vogel J., Andersson L., Antczak D.F., Biagi T.,
RA Binns M.M., Chowdhary B.P., Coleman S.J., Della Valle G., Fryc S.,
RA Guerin G., Hasegawa T., Hill E.W., Jurka J., Kiialainen A., Lindgren G.,
RA Liu J., Magnani E., Mickelson J.R., Murray J., Nergadze S.G., Onofrio R.,
RA Pedroni S., Piras M.F., Raudsepp T., Rocchi M., Roeed K.H., Ryder O.A.,
RA Searle S., Skow L., Swinburne J.E., Syvaenen A.C., Tozaki T., Valberg S.J.,
RA Vaudin M., White J.R., Zody M.C., Lander E.S., Lindblad-Toh K.;
RT "Genome sequence, comparative analysis, and population genetics of the
RT domestic horse.";
RL Science 326:865-867(2009).
RN [2] {ECO:0000313|Ensembl:ENSECAP00000040386.2}
RP IDENTIFICATION.
RC STRAIN=Thoroughbred {ECO:0000313|Ensembl:ENSECAP00000040386.2};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like
CC GTPase superfamily. Septin GTPase family.
CC {ECO:0000256|RuleBase:RU004560}.
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DR AlphaFoldDB; A0A3Q2I0C5; -.
DR Ensembl; ENSECAT00000045379.3; ENSECAP00000040386.2; ENSECAG00000020246.4.
DR VGNC; VGNC:22836; SEPTIN9.
DR GeneTree; ENSGT00940000157195; -.
DR OrthoDB; 5396944at2759; -.
DR Proteomes; UP000002281; Chromosome 11.
DR Bgee; ENSECAG00000020246; Expressed in leukocyte and 23 other cell types or tissues.
DR ExpressionAtlas; A0A3Q2I0C5; baseline.
DR GO; GO:0005930; C:axoneme; IEA:Ensembl.
DR GO; GO:0005874; C:microtubule; IEA:Ensembl.
DR GO; GO:0097730; C:non-motile cilium; IEA:Ensembl.
DR GO; GO:0048471; C:perinuclear region of cytoplasm; IEA:Ensembl.
DR GO; GO:0031105; C:septin complex; IEA:Ensembl.
DR GO; GO:0001725; C:stress fiber; IEA:Ensembl.
DR GO; GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
DR GO; GO:1902857; P:positive regulation of non-motile cilium assembly; IEA:Ensembl.
DR CDD; cd01850; CDC_Septin; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR InterPro; IPR030379; G_SEPTIN_dom.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR016491; Septin.
DR PANTHER; PTHR18884; SEPTIN; 1.
DR PANTHER; PTHR18884:SF47; SEPTIN-9; 1.
DR Pfam; PF00735; Septin; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS51719; G_SEPTIN; 1.
PE 1: Evidence at protein level;
KW Cytoplasm {ECO:0000256|ARBA:ARBA00023212};
KW Cytoskeleton {ECO:0000256|ARBA:ARBA00023212};
KW GTP-binding {ECO:0000256|ARBA:ARBA00023134, ECO:0000256|RuleBase:RU004560};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741,
KW ECO:0000256|RuleBase:RU004560};
KW Proteomics identification {ECO:0007829|PeptideAtlas:A0A3Q2I0C5};
KW Reference proteome {ECO:0000313|Proteomes:UP000002281}.
FT DOMAIN 343..615
FT /note="Septin-type G"
FT /evidence="ECO:0000259|PROSITE:PS51719"
FT REGION 167..305
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 203..217
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 634 AA; 70289 MW; F83302CAE27B4E47 CRC64;
MGVRPGDWPV PDGVPAPLSV PDSHSALAHL SQAQILELDG LGFILGSTPS SSVASGVTRT
SSGRLRRLGD LTGPALKRSF EVEEVETPNS TPPRRVQTPL LRTTVASSTQ KFQDLGVKNS
EPAARHVDSL SQRSPKAALR RVELSGPKAE PVSRRTEISI DISSKQVENA GAAGPSRFGL
KRAEGLGHKT PEPAPRRTEI TLVKSQESAH RRMETPTSKI PEVPTAPTAD AAPRRVEIQV
PKPAEVPASP IPPQTLENSE PVPMSQLQSR LEPRPHPPAA EAPPKSQEAT EAAPGCVGDM
ADTPRDAGLK QVPAPRNEKA AVDFGYVGID SILEQMRRKA MKQGFEFNIM VVGQSGLGKS
TLINTLFKSK ISRKSVQPTS EERIPKTIEI KSITHDIEEK GVRMKLTVID TPGFGDHINN
ENCWQPIMKF INDQYEKYLQ EEVNINRKKR IPDTRVHCCL YFIPATGHSL RPLDIEFMKR
LSKVVNIVPV IAKADTLTLD ERVYFKQRIT ADLLSNGIDV YPQKEFDEDS EDRLVNEKFR
EMIPFAVVGS DHEYQVNGKR ILGRKTKWGT IEVENTAHCE FAYLRDLLIR THMQNIKDIT
SSIHFEAYRV KRLHESSSAM SNGVEEKEPE AEEM
//
