ID A0A3Q2I2B2_HORSE Unreviewed; 654 AA.
AC A0A3Q2I2B2;
DT 10-APR-2019, integrated into UniProtKB/TrEMBL.
DT 13-SEP-2023, sequence version 2.
DT 27-MAR-2024, entry version 19.
DE SubName: Full=CD6 molecule {ECO:0000313|Ensembl:ENSECAP00000041923.2};
GN Name=CD6 {ECO:0000313|Ensembl:ENSECAP00000041923.2,
GN ECO:0000313|VGNC:VGNC:16274};
OS Equus caballus (Horse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Perissodactyla; Equidae; Equus.
OX NCBI_TaxID=9796 {ECO:0000313|Ensembl:ENSECAP00000041923.2, ECO:0000313|Proteomes:UP000002281};
RN [1] {ECO:0000313|Ensembl:ENSECAP00000041923.2, ECO:0000313|Proteomes:UP000002281}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Thoroughbred {ECO:0000313|Ensembl:ENSECAP00000041923.2,
RC ECO:0000313|Proteomes:UP000002281};
RX PubMed=19892987; DOI=10.1126/science.1178158;
RG Broad Institute Genome Sequencing Platform;
RG Broad Institute Whole Genome Assembly Team;
RA Wade C.M., Giulotto E., Sigurdsson S., Zoli M., Gnerre S., Imsland F.,
RA Lear T.L., Adelson D.L., Bailey E., Bellone R.R., Bloecker H., Distl O.,
RA Edgar R.C., Garber M., Leeb T., Mauceli E., MacLeod J.N., Penedo M.C.T.,
RA Raison J.M., Sharpe T., Vogel J., Andersson L., Antczak D.F., Biagi T.,
RA Binns M.M., Chowdhary B.P., Coleman S.J., Della Valle G., Fryc S.,
RA Guerin G., Hasegawa T., Hill E.W., Jurka J., Kiialainen A., Lindgren G.,
RA Liu J., Magnani E., Mickelson J.R., Murray J., Nergadze S.G., Onofrio R.,
RA Pedroni S., Piras M.F., Raudsepp T., Rocchi M., Roeed K.H., Ryder O.A.,
RA Searle S., Skow L., Swinburne J.E., Syvaenen A.C., Tozaki T., Valberg S.J.,
RA Vaudin M., White J.R., Zody M.C., Lander E.S., Lindblad-Toh K.;
RT "Genome sequence, comparative analysis, and population genetics of the
RT domestic horse.";
RL Science 326:865-867(2009).
RN [2] {ECO:0000313|Ensembl:ENSECAP00000041923.2}
RP IDENTIFICATION.
RC STRAIN=Thoroughbred {ECO:0000313|Ensembl:ENSECAP00000041923.2};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00196}.
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DR AlphaFoldDB; A0A3Q2I2B2; -.
DR Ensembl; ENSECAT00000059772.3; ENSECAP00000041923.2; ENSECAG00000011180.4.
DR VGNC; VGNC:16274; CD6.
DR GeneTree; ENSGT00940000161029; -.
DR Proteomes; UP000002281; Chromosome 12.
DR Bgee; ENSECAG00000011180; Expressed in leukocyte and 17 other cell types or tissues.
DR ExpressionAtlas; A0A3Q2I2B2; baseline.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR Gene3D; 3.10.250.10; SRCR-like domain; 3.
DR InterPro; IPR001190; SRCR.
DR InterPro; IPR017448; SRCR-like_dom.
DR InterPro; IPR036772; SRCR-like_dom_sf.
DR PANTHER; PTHR19331; SCAVENGER RECEPTOR DOMAIN-CONTAINING; 1.
DR PANTHER; PTHR19331:SF477; T-CELL DIFFERENTIATION ANTIGEN CD6; 1.
DR Pfam; PF00530; SRCR; 3.
DR PRINTS; PR00258; SPERACTRCPTR.
DR SMART; SM00202; SR; 3.
DR SUPFAM; SSF56487; SRCR-like; 3.
DR PROSITE; PS50287; SRCR_2; 3.
PE 4: Predicted;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157, ECO:0000256|PROSITE-
KW ProRule:PRU00196}; Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000002281};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 385..410
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 30..141
FT /note="SRCR"
FT /evidence="ECO:0000259|PROSITE:PS50287"
FT DOMAIN 146..245
FT /note="SRCR"
FT /evidence="ECO:0000259|PROSITE:PS50287"
FT DOMAIN 250..347
FT /note="SRCR"
FT /evidence="ECO:0000259|PROSITE:PS50287"
FT REGION 1..22
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 82..105
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 450..479
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 517..565
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 578..654
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 450..466
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 544..565
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 590..618
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 619..634
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT DISULFID 215..225
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00196"
FT DISULFID 316..326
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00196"
SQ SEQUENCE 654 AA; 69909 MW; 37846DFEAEBCBDC2 CRC64;
MSDPSPTPSG LPNTSSAQSQ TLEPGALLRV RLANGSSRCS GTVEVRLGAA WEPVCGAPWD
RRAAEAVCRA LGCGRPGATV QPATLPPELP PGPAAGNASG APNATQAPAP AVLCNGTEWR
LCEVVEGACS RDARPAQVTC SENPELRLVD GGSPCAGRVE MLEDGQWGSV CDDTWDLEDA
HVVCRQLSCG WAIQALPGLH FAPGQGPIHR DQVNCSGAES YLQDCPGQPG HGYCGHKEDA
GVVCSEHQSW RLTGGTDSCE GQVEVHFRGV WNTVCDSEWY SEEATVLCRA LGCGTAAARV
PKGLPHSLSG RMYYSCEGTE PTLSDCFWRF NNSNLCRQSQ AARVLCSGSR SLLNLSSSEA
PTSVQPLTVE SSVMVNTEDW ESRELMLLIL CIVLGVLLLG SFITIAFIFL KVKGKYALPV
MANHEHLPTT TPAGINSYQD VPVTISTKEV PNLPVQVQNP PPEDSDSSLD SDYEPYDFSA
QPPVALTTFY NSQRHRPTDE EIQQSRFQMP PLEEGLEEMH ASQVPPANSG HCIADAPSLG
PQHHPRTKSG SSTSSGEGYC NNPSGRLPLW NPQAFSAEKT PFLEPPPNLE LAGSQTTFSA
GRSADDSSST SSGEWYQNFQ PPPQPPPKEQ LEYPAPPSPQ SESTSEDYDD IGAA
//
