ID A0A3Q2I2C0_HORSE Unreviewed; 1471 AA.
AC A0A3Q2I2C0;
DT 10-APR-2019, integrated into UniProtKB/TrEMBL.
DT 13-SEP-2023, sequence version 2.
DT 27-MAR-2024, entry version 21.
DE RecName: Full=Sushi domain-containing protein {ECO:0000259|PROSITE:PS50923};
GN Name=LOC100057298 {ECO:0000313|Ensembl:ENSECAP00000041928.2};
OS Equus caballus (Horse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Perissodactyla; Equidae; Equus.
OX NCBI_TaxID=9796 {ECO:0000313|Ensembl:ENSECAP00000041928.2, ECO:0000313|Proteomes:UP000002281};
RN [1] {ECO:0000313|Ensembl:ENSECAP00000041928.2, ECO:0000313|Proteomes:UP000002281}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Thoroughbred {ECO:0000313|Ensembl:ENSECAP00000041928.2,
RC ECO:0000313|Proteomes:UP000002281};
RX PubMed=19892987; DOI=10.1126/science.1178158;
RG Broad Institute Genome Sequencing Platform;
RG Broad Institute Whole Genome Assembly Team;
RA Wade C.M., Giulotto E., Sigurdsson S., Zoli M., Gnerre S., Imsland F.,
RA Lear T.L., Adelson D.L., Bailey E., Bellone R.R., Bloecker H., Distl O.,
RA Edgar R.C., Garber M., Leeb T., Mauceli E., MacLeod J.N., Penedo M.C.T.,
RA Raison J.M., Sharpe T., Vogel J., Andersson L., Antczak D.F., Biagi T.,
RA Binns M.M., Chowdhary B.P., Coleman S.J., Della Valle G., Fryc S.,
RA Guerin G., Hasegawa T., Hill E.W., Jurka J., Kiialainen A., Lindgren G.,
RA Liu J., Magnani E., Mickelson J.R., Murray J., Nergadze S.G., Onofrio R.,
RA Pedroni S., Piras M.F., Raudsepp T., Rocchi M., Roeed K.H., Ryder O.A.,
RA Searle S., Skow L., Swinburne J.E., Syvaenen A.C., Tozaki T., Valberg S.J.,
RA Vaudin M., White J.R., Zody M.C., Lander E.S., Lindblad-Toh K.;
RT "Genome sequence, comparative analysis, and population genetics of the
RT domestic horse.";
RL Science 326:865-867(2009).
RN [2] {ECO:0000313|Ensembl:ENSECAP00000041928.2}
RP IDENTIFICATION.
RC STRAIN=Thoroughbred {ECO:0000313|Ensembl:ENSECAP00000041928.2};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00302}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR AlphaFoldDB; A0A3Q2I2C0; -.
DR STRING; 9796.ENSECAP00000041928; -.
DR PaxDb; 9796-ENSECAP00000041928; -.
DR Ensembl; ENSECAT00000052737.2; ENSECAP00000041928.2; ENSECAG00000031055.3.
DR GeneTree; ENSGT00940000160375; -.
DR InParanoid; A0A3Q2I2C0; -.
DR OMA; WTQAVPT; -.
DR Proteomes; UP000002281; Chromosome 5.
DR Bgee; ENSECAG00000031055; Expressed in blood and 8 other cell types or tissues.
DR GO; GO:0005615; C:extracellular space; IBA:GO_Central.
DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR GO; GO:0045959; P:negative regulation of complement activation, classical pathway; IBA:GO_Central.
DR GO; GO:0002456; P:T cell mediated immunity; IBA:GO_Central.
DR CDD; cd00033; CCP; 20.
DR Gene3D; 2.10.70.10; Complement Module, domain 1; 21.
DR InterPro; IPR035976; Sushi/SCR/CCP_sf.
DR InterPro; IPR000436; Sushi_SCR_CCP_dom.
DR PANTHER; PTHR19325; COMPLEMENT COMPONENT-RELATED SUSHI DOMAIN-CONTAINING; 1.
DR PANTHER; PTHR19325:SF573; SUSHI DOMAIN-CONTAINING PROTEIN; 1.
DR Pfam; PF00084; Sushi; 20.
DR SMART; SM00032; CCP; 22.
DR SUPFAM; SSF57535; Complement control module/SCR domain; 22.
DR PROSITE; PS50923; SUSHI; 21.
PE 4: Predicted;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157, ECO:0000256|PROSITE-
KW ProRule:PRU00302}; Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000002281};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP};
KW Sushi {ECO:0000256|PROSITE-ProRule:PRU00302};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..20
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 21..1471
FT /note="Sushi domain-containing protein"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5040276105"
FT TRANSMEM 1410..1437
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 20..80
FT /note="Sushi"
FT /evidence="ECO:0000259|PROSITE:PS50923"
FT DOMAIN 81..142
FT /note="Sushi"
FT /evidence="ECO:0000259|PROSITE:PS50923"
FT DOMAIN 143..213
FT /note="Sushi"
FT /evidence="ECO:0000259|PROSITE:PS50923"
FT DOMAIN 215..272
FT /note="Sushi"
FT /evidence="ECO:0000259|PROSITE:PS50923"
FT DOMAIN 274..334
FT /note="Sushi"
FT /evidence="ECO:0000259|PROSITE:PS50923"
FT DOMAIN 335..397
FT /note="Sushi"
FT /evidence="ECO:0000259|PROSITE:PS50923"
FT DOMAIN 398..461
FT /note="Sushi"
FT /evidence="ECO:0000259|PROSITE:PS50923"
FT DOMAIN 466..526
FT /note="Sushi"
FT /evidence="ECO:0000259|PROSITE:PS50923"
FT DOMAIN 530..590
FT /note="Sushi"
FT /evidence="ECO:0000259|PROSITE:PS50923"
FT DOMAIN 591..651
FT /note="Sushi"
FT /evidence="ECO:0000259|PROSITE:PS50923"
FT DOMAIN 652..722
FT /note="Sushi"
FT /evidence="ECO:0000259|PROSITE:PS50923"
FT DOMAIN 727..785
FT /note="Sushi"
FT /evidence="ECO:0000259|PROSITE:PS50923"
FT DOMAIN 786..846
FT /note="Sushi"
FT /evidence="ECO:0000259|PROSITE:PS50923"
FT DOMAIN 903..973
FT /note="Sushi"
FT /evidence="ECO:0000259|PROSITE:PS50923"
FT DOMAIN 978..1036
FT /note="Sushi"
FT /evidence="ECO:0000259|PROSITE:PS50923"
FT DOMAIN 1037..1097
FT /note="Sushi"
FT /evidence="ECO:0000259|PROSITE:PS50923"
FT DOMAIN 1098..1152
FT /note="Sushi"
FT /evidence="ECO:0000259|PROSITE:PS50923"
FT DOMAIN 1153..1217
FT /note="Sushi"
FT /evidence="ECO:0000259|PROSITE:PS50923"
FT DOMAIN 1222..1281
FT /note="Sushi"
FT /evidence="ECO:0000259|PROSITE:PS50923"
FT DOMAIN 1285..1345
FT /note="Sushi"
FT /evidence="ECO:0000259|PROSITE:PS50923"
FT DOMAIN 1346..1406
FT /note="Sushi"
FT /evidence="ECO:0000259|PROSITE:PS50923"
FT DISULFID 22..65
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00302"
FT DISULFID 245..272
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00302"
FT DISULFID 276..319
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00302"
FT DISULFID 305..332
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00302"
FT DISULFID 532..575
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00302"
FT DISULFID 561..588
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00302"
FT DISULFID 757..784
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00302"
FT DISULFID 788..831
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00302"
FT DISULFID 817..844
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00302"
FT DISULFID 1008..1035
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00302"
FT DISULFID 1039..1082
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00302"
FT DISULFID 1068..1095
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00302"
FT DISULFID 1155..1198
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00302"
FT DISULFID 1252..1279
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00302"
FT DISULFID 1287..1330
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00302"
FT DISULFID 1316..1343
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00302"
FT DISULFID 1348..1391
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00302"
FT DISULFID 1377..1404
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00302"
SQ SEQUENCE 1471 AA; 162007 MW; 39F2A7AB4CAC9D44 CRC64;
MGAPGLLWVF LALVAPGVLG QCKFLPRYPF AKPKIQSDQS EFAVGTSWEY ECLPGFIKSS
FFTTCLETSE WSDAQQFCKR KSCMSPRELL HGSVHTPMGI VFGSTITYSC DEGYRLIGDS
SATCIISDNI VTWDSDMPFC EIIPCESPPA ISNGDFYSSS REHFYYGMVV TYECHIGQNG
KKLFDLVGEP SIYCTSKDNR IGIWSSPPPQ CITVVKCPVP EVENGIMESG FRRSFSLNDT
VMFKCKPGFT MKGSNIVWCQ PNSKWNPPLP KCFKGCLLPP DIANGSYSKM DKEFFQIGQK
VSYSCEPGYT LIGTNPVQCT SLGTWSPTAP RCEAKSCDVI PNQLLNGRVV APPSLRLGAE
VSFVCDKGYR LNGKSSSQCV VEGMKVLWNN KFPVCERIYC DPPPSIKHGW NSYPSGPIPL
NTVVRYSCPG AFRLIGERNI FCRSKDQVKG VWDKAAPICE YYNRNTICRE PVVPGGRRNK
MSKPPYRHGD SVTFTCDIHF TMKGNKSVWC QANNTWGPTP LPICESDFPL ECPSLPRISN
GHHTGETVGK FTPGLSVTYS CDPGYLLVGQ KTIKCLSSGD WSSGIPTCKE AQCKDPGPFL
NGQIAGPEKF RAGVTVDFSC KEGYRLEGPP SSQCVIVGQN ALWTKMPTCK EILCPAPPPI
LHGRHTGSSS VNVPYGSRVT YTCDSDPEKG VNFILIGKNT IYCTADSQKT GTWSGPAPRC
ELSVSGVQCP PPKILRGRIL SGQKNQYSYN DTVVFACAFG FTLKGSKGIR CNAQGTWEPP
EPVCEKECQA PPKILNGRKE DRHMIRFDPG TSIKYSCDPG YVLVGEESIH CSFEGVWTPT
APKCKVAECK PIGEQLFVKP QDQFIRSDVN SSCGEGYRLG ESVYQLCQGT IPWYVEIRLC
EEITCPPPPV IYNGIYTGIS SEDIPYGTTV TYTCNPGPEK GVKFNLIGAS TIHCISNNQK
RGIWSGPAPL CKLSLPAVQC SHVHVANGYK VSGKEAPYFY NDTVTFKCDH GFTLKGSSQI
RCKANNTWDP EIPVCEKDCQ PPSGLHHGRH TGGNRVHFVS GMTVDYTCDP GYLLVGNKSI
YCMPSGNWSP SAPRCEEAPC QPVRHQELPL DSHVVQVNTS CKDGYQLTGH AYRKCQDAEN
GVWFQKIPLC KVIQCQPPPV IDNGRLTGVM AQHFLYGNEV SYACDQGFYL LGQKSIRCIS
DSKGHGSWSG PPPQCLKSSP VTHCPNPEVR HGYKLNNTQS SYSHNDTVYV ACNPGFIMNG
SHLIRCHTNN KWVPGIPTCI KKAVSDCQPP DRIPNGNYTA TDIVRFFPGV SILYSCDEGY
LLVGEAVLVC TQEGTWSQPA PFCKEVNCSF PEHMTGMQKG LEPGKMYQYG AIVTLECEDG
YTLEGSPQSQ CQDDHGWNPP LAVCRSPSSF APLLFCGLSA GLVFLVFLIS VALCMILKHK
ERNYYTNTGH KEDIHLEAKE VYSIDPYNPA S
//
