ID A0A3Q2I3S4_HORSE Unreviewed; 906 AA.
AC A0A3Q2I3S4;
DT 10-APR-2019, integrated into UniProtKB/TrEMBL.
DT 13-SEP-2023, sequence version 2.
DT 27-MAR-2024, entry version 23.
DE SubName: Full=Synaptosome associated protein 91 {ECO:0000313|Ensembl:ENSECAP00000042539.2};
GN Name=SNAP91 {ECO:0000313|Ensembl:ENSECAP00000042539.2,
GN ECO:0000313|VGNC:VGNC:23377};
OS Equus caballus (Horse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Perissodactyla; Equidae; Equus.
OX NCBI_TaxID=9796 {ECO:0000313|Ensembl:ENSECAP00000042539.2, ECO:0000313|Proteomes:UP000002281};
RN [1] {ECO:0000313|Ensembl:ENSECAP00000042539.2, ECO:0000313|Proteomes:UP000002281}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Thoroughbred {ECO:0000313|Ensembl:ENSECAP00000042539.2,
RC ECO:0000313|Proteomes:UP000002281};
RX PubMed=19892987; DOI=10.1126/science.1178158;
RG Broad Institute Genome Sequencing Platform;
RG Broad Institute Whole Genome Assembly Team;
RA Wade C.M., Giulotto E., Sigurdsson S., Zoli M., Gnerre S., Imsland F.,
RA Lear T.L., Adelson D.L., Bailey E., Bellone R.R., Bloecker H., Distl O.,
RA Edgar R.C., Garber M., Leeb T., Mauceli E., MacLeod J.N., Penedo M.C.T.,
RA Raison J.M., Sharpe T., Vogel J., Andersson L., Antczak D.F., Biagi T.,
RA Binns M.M., Chowdhary B.P., Coleman S.J., Della Valle G., Fryc S.,
RA Guerin G., Hasegawa T., Hill E.W., Jurka J., Kiialainen A., Lindgren G.,
RA Liu J., Magnani E., Mickelson J.R., Murray J., Nergadze S.G., Onofrio R.,
RA Pedroni S., Piras M.F., Raudsepp T., Rocchi M., Roeed K.H., Ryder O.A.,
RA Searle S., Skow L., Swinburne J.E., Syvaenen A.C., Tozaki T., Valberg S.J.,
RA Vaudin M., White J.R., Zody M.C., Lander E.S., Lindblad-Toh K.;
RT "Genome sequence, comparative analysis, and population genetics of the
RT domestic horse.";
RL Science 326:865-867(2009).
RN [2] {ECO:0000313|Ensembl:ENSECAP00000042539.2}
RP IDENTIFICATION.
RC STRAIN=Thoroughbred {ECO:0000313|Ensembl:ENSECAP00000042539.2};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the PICALM/SNAP91 family.
CC {ECO:0000256|ARBA:ARBA00008011}.
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DR AlphaFoldDB; A0A3Q2I3S4; -.
DR Ensembl; ENSECAT00000036992.2; ENSECAP00000042539.2; ENSECAG00000006998.4.
DR VGNC; VGNC:23377; SNAP91.
DR GeneTree; ENSGT00950000183068; -.
DR Proteomes; UP000002281; Chromosome 10.
DR Bgee; ENSECAG00000006998; Expressed in prefrontal cortex and 16 other cell types or tissues.
DR ExpressionAtlas; A0A3Q2I3S4; baseline.
DR GO; GO:0030136; C:clathrin-coated vesicle; IEA:InterPro.
DR GO; GO:0005545; F:1-phosphatidylinositol binding; IEA:InterPro.
DR GO; GO:0030276; F:clathrin binding; IEA:InterPro.
DR GO; GO:0048268; P:clathrin coat assembly; IEA:InterPro.
DR GO; GO:0072583; P:clathrin-dependent endocytosis; IEA:InterPro.
DR CDD; cd16985; ANTH_N_AP180; 1.
DR Gene3D; 1.25.40.90; -; 1.
DR Gene3D; 1.20.58.150; ANTH domain; 1.
DR InterPro; IPR011417; ANTH_dom.
DR InterPro; IPR014712; ANTH_dom_sf.
DR InterPro; IPR045192; AP180-like.
DR InterPro; IPR013809; ENTH.
DR InterPro; IPR008942; ENTH_VHS.
DR PANTHER; PTHR22951; CLATHRIN ASSEMBLY PROTEIN; 1.
DR PANTHER; PTHR22951:SF4; CLATHRIN COAT ASSEMBLY PROTEIN AP180; 1.
DR Pfam; PF07651; ANTH; 1.
DR SMART; SM00273; ENTH; 1.
DR SUPFAM; SSF48464; ENTH/VHS domain; 1.
DR SUPFAM; SSF89009; GAT-like domain; 1.
DR PROSITE; PS50942; ENTH; 1.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000002281}.
FT DOMAIN 14..145
FT /note="ENTH"
FT /evidence="ECO:0000259|PROSITE:PS50942"
FT REGION 285..325
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 393..427
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 448..533
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 788..822
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 863..906
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 285..323
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 906 AA; 92325 MW; 3ED7DC8E4DE34E73 CRC64;
MSGQTLTDRI AAAQYSVTGS AVARAVCKAT THEVMGPKKK HLDYLIQATN ETNVNIPQMA
DTLFERATNS SWVVVFKALV TTHHLMVHGN ERFIQYLASR NTLFNLSNFL DKSGSHGYDM
STFIRRYSRY LNEKAFSYRQ MAFDFARVKK GADGVMRTMA PEKLLKSMPI LQGQIDALLE
FDVHPNELTN GVINAAFMLL FKDLIKLFAC YNDGVINLLE KFFEMKKGQC KDALEIYKRF
LTRMTRVSEF LKVAEQVGID KGDIPDLTQA PSSLMETLEQ HLNTLEGKKP GNNEGSGAPS
PLSKSSPATT VTSPNSTPAK TIDTSPPVDL FATASAAVPV SASKPSSDLL DLQPDFSSAG
AAAAAAPAPA PPSGGATAWG DLLGEDSLAA LSSVPSEAQI SDPFAPEPSP PTTAAEIATA
SASASTTTTV TAVTAEVDLF GDAFAASPGE APAAPEGAAA PAPPTPVAAA LDACSGNDPF
APSEGSAEAA PELDLFAMKP PETSVPVVTP TASTAPPVPA TAPSPAPAVA AATAATTAAT
TAATTTATTS ATTTTAPPAL DIFGDLFDSA PEVAAAPKPD AAPSIDLFGT DAFSSPPQGA
SPVPESSLTA DLLSVDAFAA PSPAATASPA KVDSSGVIDL FGDAFGSSAS EPQPAPQAAS
SSSASADLLA GFGGSFMAPS PSPVTPAQNN LLQPNFEAAF GTTPSTSSSS SFDPSVFDGL
GDLLMPTVAP AGQPAPISVA PPSPAMAASK ALGSDLDSSL ASLVGNLGIS GTTSKKGDLQ
WNAGEKKLTG GANWQPKVAP ATWSAGVPPS APLQGTVPPT SSVPPVAGAP PVGQPGAGFG
MPPAGTGMPM MPQQPVMFAQ PMMRPPFGAT AVPGTQLSPS PTPATQSPKK PPAKDPLADL
NIKDFL
//
