ID A0A3Q2I423_HORSE Unreviewed; 2659 AA.
AC A0A3Q2I423;
DT 10-APR-2019, integrated into UniProtKB/TrEMBL.
DT 10-APR-2019, sequence version 1.
DT 27-MAR-2024, entry version 19.
DE SubName: Full=Neurobeachin like 1 {ECO:0000313|Ensembl:ENSECAP00000042659.1};
GN Name=NBEAL1 {ECO:0000313|Ensembl:ENSECAP00000042659.1,
GN ECO:0000313|VGNC:VGNC:51476};
OS Equus caballus (Horse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Perissodactyla; Equidae; Equus.
OX NCBI_TaxID=9796 {ECO:0000313|Ensembl:ENSECAP00000042659.1, ECO:0000313|Proteomes:UP000002281};
RN [1] {ECO:0000313|Ensembl:ENSECAP00000042659.1, ECO:0000313|Proteomes:UP000002281}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Thoroughbred {ECO:0000313|Ensembl:ENSECAP00000042659.1,
RC ECO:0000313|Proteomes:UP000002281};
RX PubMed=19892987; DOI=10.1126/science.1178158;
RG Broad Institute Genome Sequencing Platform;
RG Broad Institute Whole Genome Assembly Team;
RA Wade C.M., Giulotto E., Sigurdsson S., Zoli M., Gnerre S., Imsland F.,
RA Lear T.L., Adelson D.L., Bailey E., Bellone R.R., Bloecker H., Distl O.,
RA Edgar R.C., Garber M., Leeb T., Mauceli E., MacLeod J.N., Penedo M.C.T.,
RA Raison J.M., Sharpe T., Vogel J., Andersson L., Antczak D.F., Biagi T.,
RA Binns M.M., Chowdhary B.P., Coleman S.J., Della Valle G., Fryc S.,
RA Guerin G., Hasegawa T., Hill E.W., Jurka J., Kiialainen A., Lindgren G.,
RA Liu J., Magnani E., Mickelson J.R., Murray J., Nergadze S.G., Onofrio R.,
RA Pedroni S., Piras M.F., Raudsepp T., Rocchi M., Roeed K.H., Ryder O.A.,
RA Searle S., Skow L., Swinburne J.E., Syvaenen A.C., Tozaki T., Valberg S.J.,
RA Vaudin M., White J.R., Zody M.C., Lander E.S., Lindblad-Toh K.;
RT "Genome sequence, comparative analysis, and population genetics of the
RT domestic horse.";
RL Science 326:865-867(2009).
RN [2] {ECO:0000313|Ensembl:ENSECAP00000042659.1}
RP IDENTIFICATION.
RC STRAIN=Thoroughbred {ECO:0000313|Ensembl:ENSECAP00000042659.1};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR Ensembl; ENSECAT00000035132.3; ENSECAP00000042659.1; ENSECAG00000020049.4.
DR VGNC; VGNC:51476; NBEAL1.
DR GeneTree; ENSGT00940000155041; -.
DR Proteomes; UP000002281; Chromosome 18.
DR Bgee; ENSECAG00000020049; Expressed in brainstem and 23 other cell types or tissues.
DR ExpressionAtlas; A0A3Q2I423; baseline.
DR CDD; cd06071; Beach; 1.
DR CDD; cd01201; PH_BEACH; 1.
DR Gene3D; 1.10.1540.10; BEACH domain; 1.
DR Gene3D; 2.130.10.10; YVTN repeat-like/Quinoprotein amine dehydrogenase; 1.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR000409; BEACH_dom.
DR InterPro; IPR036372; BEACH_dom_sf.
DR InterPro; IPR013320; ConA-like_dom_sf.
DR InterPro; IPR046851; NBCH_WD40.
DR InterPro; IPR031570; NBEA/BDCP_DUF4704.
DR InterPro; IPR023362; PH-BEACH_dom.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR InterPro; IPR036322; WD40_repeat_dom_sf.
DR InterPro; IPR001680; WD40_rpt.
DR PANTHER; PTHR13743; BEIGE/BEACH-RELATED; 1.
DR PANTHER; PTHR13743:SF115; NEUROBEACHIN-LIKE PROTEIN 1; 1.
DR Pfam; PF02138; Beach; 1.
DR Pfam; PF15787; DUF4704; 1.
DR Pfam; PF16057; DUF4800; 1.
DR Pfam; PF20426; NBCH_WD40; 1.
DR Pfam; PF14844; PH_BEACH; 1.
DR SMART; SM01026; Beach; 1.
DR SMART; SM00320; WD40; 3.
DR SUPFAM; SSF48371; ARM repeat; 1.
DR SUPFAM; SSF81837; BEACH domain; 1.
DR SUPFAM; SSF49899; Concanavalin A-like lectins/glucanases; 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR SUPFAM; SSF50978; WD40 repeat-like; 1.
DR PROSITE; PS50197; BEACH; 1.
DR PROSITE; PS51783; PH_BEACH; 1.
DR PROSITE; PS50082; WD_REPEATS_2; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000002281};
KW WD repeat {ECO:0000256|PROSITE-ProRule:PRU00221}.
FT DOMAIN 1883..1981
FT /note="BEACH-type PH"
FT /evidence="ECO:0000259|PROSITE:PS51783"
FT DOMAIN 1957..2249
FT /note="BEACH"
FT /evidence="ECO:0000259|PROSITE:PS50197"
FT REPEAT 2453..2494
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REGION 1287..1307
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1382..1419
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 2659 AA; 302635 MW; C688282C945818A3 CRC64;
MASRERLFEL WMLYCTKKDP DYLKLWLDNF VSSYEQFLDV DFEKLPTRVD DVPPGISLLP
DNILQVLRIQ LLQCVQKMAD GLEEQQQALS ILLVKFFIIL CRNLSNVEEI GTCSYINYVI
TMTTLYIQQL KSKKKEKELA DQTSIEEFVI HALAFCESLY DPYRNWRHRI SGRILSTVEK
SRQKYKPASL TVEFVPFFYQ CFQESEHLKE SLKCCLLHLF GAIIAGGQRN ALQAISPATM
EVLMRVLADC DSWEDGNPEE VGRKVELTLK CLTEVVHILL ASSSDQRQVE TSTLLENYFK
LLNSDHSALP NQRRSRQWES RFIALQIKML NTITAMLDCT DRPVLQAIFL NSNCFEHLIR
LLQNCKVFQG QLDCLAVSTI QALTAVMNKS PAAKEVFKER IGYTHMFEVL KSLGQPAVEL
LKELMNMAVE GDHTSVGILG ISNVQPLLLL IQWLPELESH DLQIFISDWL KRICCINRQS
RTTCVNANMG IRIIETLDSH SSLHRTCAEN LIALHGSLGS QSVSSEEIRR LLRLLRVDES
ECVHPYATPV TRAILTMARK QSLESALQYF NLSHSMAGIT VPSIQKWPGS AFSFNAWFCL
DQDQLTPGSA NKGGKRKQLY SFFTGSGMGF EAFITHSGTL VVAVCTKREY ATVMLPDHSF
CDSLWHNITI VHMPGKRPFG QSVVFIYDNG QQKVSAPLRF PAMNEAFVSC CIGSAGQRTT
TPPPSQIPDP PFSSPITPHR TSFGGILSSA SWGGTIEKSK LITKLISAGT QDSEWGCPTS
LEGQLGSVII FCEALQPPQV KALYLAGPNC LSPWKFQESD MADLPGNVLL HYTAKACKNS
ICLDLSANCL HGRLTGNKVV NWDIKDIINC IGGLNVLFPL LEQISHSSEG QIAEGMNEST
VSELITPVEG DWVVLTSTKA SESRLERNLI ATFILIVKHF IQRHPINQDN LIHSHGVATL
GALLQKVPST LMDVNVLMAI QLLIEQVSLE KNMQLLQQMY QYLLFDFRIW NRGDFPFRIG
HIQYLSTIIK DSRRVFRKKY GVQFLLDTLR IYYGSDCKYS ELSLDDIRTI RTSLYGLIKY
FLCKGGTHEE IQSIMGYIAA ISEEEQLFGI LDILFSLLRT SPTRGQLFLL LFEPGNADIL
YALLLNQKYS DRLREVIFKV MEQMLKCTNV YERSKQRIRL REVGYSGLGL LLSEAPVNTS
LLKNLTNQIV NADPAINFKD LLSVVYMSRR AHINVRVVIC RKILQILQSQ PDAAHQISQQ
VGWQDTLVRL FLKANFENGN TLHKHSRAVS MKDNDKNISA DDNKRNFDEK MDEEKINSFA
STNVSSDQWS LEDRRSLDSN TPLFQEDSSV GELSFKSENQ EEFWHHSPSH LSLDLSRIDS
CELSDSGGQM PDSLPSTPSP IESTKSFSVP SDKESSITSD TGFSDDFSLL ESQERCEEEL
LQLLTNILSY VMCKGLEKSD DDAWIERGQV FAALTKPGIS SELLRPSDEI KLILLQKMLE
WTVTENREAK TNPVTAENAF RLMLIVQDFL QSEGLVNPNV WTEKLLENMM QLFDGLSVWY
SESPVWVKLS QIQIQLLLGF IGRGNLQVCA MASAKLNTLL QTKVIENQDE ACYILGKLEH
VLSQSVKEQT ETYSFLIPLV RTLVSKIYEL LFMNLHLPSL PFTNGSSSFF EDFQEYCSSN
EWQVYIEKYI VPYMKQYETH TFYDGHENMA LYWKDCYEAL MVNMHKRDRE GGESKLKFQE
FFVEPFNRKA RQENLRYNNM LKQLSSQQLA ALRRWKAVQL YLTCERGPWA ERKQNPIHWK
LANVENYSRM RLKLVPNYNF KTHEEASALR DNLGVQHSQP SSDSLLLEVV KQVKVSDMEE
DKLDLPEEEI TARVNIDEKE EQDQKEKLVL SEDCELITMI DVVPGRLEIT TQHIYFYDGS
IEKEDGVGFD FKWPHSQVRE IHLRRYNLRR SALEIFHVDQ SNYFLNFKKE KWVNREISNF
DYLIQINTMA GRTYNDLAQY PVFPWILQDY TSEELDLNNP SVFRDLSKPI GVINDKNAKA
MREKYENFED PMGTIDKFHY GTHYSNSAGV MHYLIRTEPF TTLHIQLQSG RFDCADRQFH
SIPATWQALM DNPYDVKELI PEFFYFPEFL ENQNEFNLGH LQVSKELVND VILPKWAKSA
EDFIYKHRKA LESEYVSAHL HEWIDLIFGY KQRGPAAVEA LNVFYYCSYE GAVDLDALTD
EKERKALEGM INNFGQTPCQ LLKEPHPPRL SAEEAVQKQT KMDTPSLNLF QHLPELKSFF
IEGISDGIPL IKAIVPKNQS RSFMSQGSPE LLITVSMNYV IGTHGWLPYD RSISNYFTFI
RDPTVTNPKT QRSMNGPFAP GLEITSKLFI VSHDAKLLFS AGHWDNSIQV MSLTKGKVIS
HNIRHMDIVT CLATDYCGIH LISGSRDTTC MIWQITQQGG VPVGLASKPF QILYGHTDEV
LSVGISTELD MAVSGSRDGT VIIHTIQKGQ YMRTLRPPCE SSLLLTVPSL AISWEGHVVI
YSSIEEKTTL KDKNALHVFS VNGKYLRSQV LKEQVSDMCV IGEHVITGSL QGFLSIRDLH
SLNLSINPLA MRLPIHCVCV TKEHSHILVG LEDGKLIVVG VGKPAEMRSG QLTRKLWGSS
KRLSQISAGE TEYNTQDPK
//
