ID A0A3Q2I451_HORSE Unreviewed; 1178 AA.
AC A0A3Q2I451;
DT 10-APR-2019, integrated into UniProtKB/TrEMBL.
DT 13-SEP-2023, sequence version 3.
DT 27-MAR-2024, entry version 22.
DE SubName: Full=Integrin subunit alpha 7 {ECO:0000313|Ensembl:ENSECAP00000042573.3};
GN Name=ITGA7 {ECO:0000313|Ensembl:ENSECAP00000042573.3,
GN ECO:0000313|VGNC:VGNC:19168};
OS Equus caballus (Horse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Perissodactyla; Equidae; Equus.
OX NCBI_TaxID=9796 {ECO:0000313|Ensembl:ENSECAP00000042573.3, ECO:0000313|Proteomes:UP000002281};
RN [1] {ECO:0000313|Ensembl:ENSECAP00000042573.3, ECO:0000313|Proteomes:UP000002281}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Thoroughbred {ECO:0000313|Ensembl:ENSECAP00000042573.3,
RC ECO:0000313|Proteomes:UP000002281};
RX PubMed=19892987; DOI=10.1126/science.1178158;
RG Broad Institute Genome Sequencing Platform;
RG Broad Institute Whole Genome Assembly Team;
RA Wade C.M., Giulotto E., Sigurdsson S., Zoli M., Gnerre S., Imsland F.,
RA Lear T.L., Adelson D.L., Bailey E., Bellone R.R., Bloecker H., Distl O.,
RA Edgar R.C., Garber M., Leeb T., Mauceli E., MacLeod J.N., Penedo M.C.T.,
RA Raison J.M., Sharpe T., Vogel J., Andersson L., Antczak D.F., Biagi T.,
RA Binns M.M., Chowdhary B.P., Coleman S.J., Della Valle G., Fryc S.,
RA Guerin G., Hasegawa T., Hill E.W., Jurka J., Kiialainen A., Lindgren G.,
RA Liu J., Magnani E., Mickelson J.R., Murray J., Nergadze S.G., Onofrio R.,
RA Pedroni S., Piras M.F., Raudsepp T., Rocchi M., Roeed K.H., Ryder O.A.,
RA Searle S., Skow L., Swinburne J.E., Syvaenen A.C., Tozaki T., Valberg S.J.,
RA Vaudin M., White J.R., Zody M.C., Lander E.S., Lindblad-Toh K.;
RT "Genome sequence, comparative analysis, and population genetics of the
RT domestic horse.";
RL Science 326:865-867(2009).
RN [2] {ECO:0000313|Ensembl:ENSECAP00000042573.3}
RP IDENTIFICATION.
RC STRAIN=Thoroughbred {ECO:0000313|Ensembl:ENSECAP00000042573.3};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004479,
CC ECO:0000256|RuleBase:RU003762}; Single-pass type I membrane protein
CC {ECO:0000256|ARBA:ARBA00004479, ECO:0000256|RuleBase:RU003762}.
CC -!- SIMILARITY: Belongs to the integrin alpha chain family.
CC {ECO:0000256|ARBA:ARBA00008054, ECO:0000256|RuleBase:RU003762}.
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DR AlphaFoldDB; A0A3Q2I451; -.
DR Ensembl; ENSECAT00000042104.3; ENSECAP00000042573.3; ENSECAG00000011735.4.
DR VGNC; VGNC:19168; ITGA7.
DR GeneTree; ENSGT00940000159891; -.
DR Proteomes; UP000002281; Chromosome 6.
DR Bgee; ENSECAG00000011735; Expressed in chorionic villus and 23 other cell types or tissues.
DR GO; GO:0008305; C:integrin complex; IEA:InterPro.
DR GO; GO:0007155; P:cell adhesion; IEA:UniProtKB-KW.
DR GO; GO:0007229; P:integrin-mediated signaling pathway; IEA:UniProtKB-KW.
DR Gene3D; 1.20.5.930; Bicelle-embedded integrin alpha(iib) transmembrane segment; 1.
DR Gene3D; 2.130.10.130; Integrin alpha, N-terminal; 1.
DR Gene3D; 2.60.40.1460; Integrin domains. Chain A, domain 2; 1.
DR Gene3D; 2.60.40.1510; ntegrin, alpha v. Chain A, domain 3; 1.
DR Gene3D; 2.60.40.1530; ntegrin, alpha v. Chain A, domain 4; 1.
DR InterPro; IPR013517; FG-GAP.
DR InterPro; IPR013519; Int_alpha_beta-p.
DR InterPro; IPR000413; Integrin_alpha.
DR InterPro; IPR013649; Integrin_alpha_Ig-like_1.
DR InterPro; IPR048285; Integrin_alpha_Ig-like_2.
DR InterPro; IPR048286; Integrin_alpha_Ig-like_3.
DR InterPro; IPR028994; Integrin_alpha_N.
DR InterPro; IPR032695; Integrin_dom_sf.
DR PANTHER; PTHR23220; INTEGRIN ALPHA; 1.
DR PANTHER; PTHR23220:SF90; INTEGRIN ALPHA-7; 1.
DR Pfam; PF01839; FG-GAP; 2.
DR Pfam; PF08441; Integrin_A_Ig_1; 1.
DR Pfam; PF20805; Integrin_A_Ig_2; 1.
DR Pfam; PF20806; Integrin_A_Ig_3; 1.
DR PRINTS; PR01185; INTEGRINA.
DR SMART; SM00191; Int_alpha; 5.
DR SUPFAM; SSF69318; Integrin alpha N-terminal domain; 1.
DR SUPFAM; SSF69179; Integrin domains; 3.
DR PROSITE; PS51470; FG_GAP; 5.
PE 3: Inferred from homology;
KW Cell adhesion {ECO:0000256|ARBA:ARBA00022889,
KW ECO:0000256|RuleBase:RU003762};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Integrin {ECO:0000256|ARBA:ARBA00023037, ECO:0000256|RuleBase:RU003762};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU003762};
KW Receptor {ECO:0000256|ARBA:ARBA00023170, ECO:0000256|RuleBase:RU003762};
KW Reference proteome {ECO:0000313|Proteomes:UP000002281};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Signal {ECO:0000256|ARBA:ARBA00022729};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU003762};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|RuleBase:RU003762}.
FT TRANSMEM 1081..1103
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU003762"
FT REPEAT 78..146
FT /note="FG-GAP"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00803"
FT REPEAT 228..281
FT /note="FG-GAP"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00803"
FT REPEAT 349..410
FT /note="FG-GAP"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00803"
FT REPEAT 411..466
FT /note="FG-GAP"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00803"
FT REPEAT 470..529
FT /note="FG-GAP"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00803"
FT DOMAIN 514..678
FT /note="Integrin alpha first immunoglubulin-like"
FT /evidence="ECO:0000259|Pfam:PF08441"
FT DOMAIN 680..844
FT /note="Integrin alpha second immunoglobulin-like"
FT /evidence="ECO:0000259|Pfam:PF20805"
FT DOMAIN 850..1068
FT /note="Integrin alpha third immunoglobulin-like"
FT /evidence="ECO:0000259|Pfam:PF20806"
FT REGION 949..981
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 949..968
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1178 AA; 128550 MW; 36D5BEACAD550BF2 CRC64;
MGRPLKHLED SETRDHRPAW GDLGLPARAN FLALVGSARG VRPMAGTSGR DPWGALGICY
LLGSLLAGLL SPRAVAFNLD VMGALLKEGE PDSLFGFSVA LHRQLQPRPQ SWLLVGAPQA
LALPGQQANR TGGLFACPLS LEETDCYRVD IDRGADVQKE SKENQWLGVS VRSQGPGGKI
VTCAHRYEAR QRVDQMLETR DVIGRCFVLS QDLAIRDELD GGEWKFCEGR PQGHEQFGFC
QQGTAAAFSP DSHYLLFGAP GTYNWKGLLF VTNIDSSDPD QLVYKTLDPA DRLPGPAGDL
ALNSYLGFSI DSGKGLVRAE ELSFVAGAPR ANHTGAVVIL RKDSASRLVP EVTLFGERLT
SGFGYSLAVA DLNNDGWTDL VVGAPYFFER QEELGGAVYV YLNQGGHWAE VSPLRLCGSP
DSMFGISLAV LGDLNQDGFP DIAVGAPFDG HGKVFIYHGS SLGVVVKPSQ VLEGEAVGIK
SFGYSLSGGL DVDGNHYPDL LVGSLADTAV LFRARPVLHV SHEVFIAPRT IDLEQPNCAG
GHSVCVDLRV CFSYIAAPSS YSPIVALDYV LDGDTDRRLR GQVPRVTFLS RGPDDPKHQA
SGTVWLKHQH DRVCGDTLFQ LQENVKDKLR AIVVTLSYSL QTPRLRRQAL DQGLPPVAPI
LSAHQPSSQR AEIHFLKQGC GEDKICQSNL QLVHARFCAR VSDTEFQPLP MDADGTTALF
ALSGQPVIGL ELKVTNLPSD PAQPQADGDD AHEAQLLVTL PASLHYSGVR ALDPVEKPLC
LSNENASHVE CELGNPMKRG AQVTFYLILS TSGITIETTE LEVELLLATI SEQELHPVSA
RARVFIELPL SITGVAIPQQ LFFSGVVRGE SAMQSERDVG SKVKYEVTVS NQGQSLNTLG
SAFLNIMWPH EIANGKWLLY PMRVELEGGQ GPGQKGLCSP RPNILHLDVD SRDRRRRELE
RPEQQEPREP PEPSTSWWPV SSAEKKKNVT LDCARGTANC VVFSCPLYSF DRAAVLHVWG
RLWNSTFLEE YSAVKSLEVI VRANITVKSS IKNLLLRDAS TVIPVMVYLD PVAVVAEGVP
WWVILLAVLA GLLVLALLVL LLWKAITAIT RGQILSQMPQ LDHAELCTSL GLCGEFHHDL
LPGPITDQTH PFVDMSHQWP RPLEQHPNCW NLARPRGD
//