ID A0A3Q2I5L3_HORSE Unreviewed; 857 AA.
AC A0A3Q2I5L3;
DT 10-APR-2019, integrated into UniProtKB/TrEMBL.
DT 10-APR-2019, sequence version 1.
DT 27-MAR-2024, entry version 26.
DE SubName: Full=Transient receptor potential cation channel subfamily V member 4 {ECO:0000313|Ensembl:ENSECAP00000043311.1};
GN Name=TRPV4 {ECO:0000313|VGNC:VGNC:24567};
OS Equus caballus (Horse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Perissodactyla; Equidae; Equus.
OX NCBI_TaxID=9796 {ECO:0000313|Ensembl:ENSECAP00000043311.1, ECO:0000313|Proteomes:UP000002281};
RN [1] {ECO:0000313|Ensembl:ENSECAP00000043311.1, ECO:0000313|Proteomes:UP000002281}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Thoroughbred {ECO:0000313|Ensembl:ENSECAP00000043311.1,
RC ECO:0000313|Proteomes:UP000002281};
RX PubMed=19892987; DOI=10.1126/science.1178158;
RG Broad Institute Genome Sequencing Platform;
RG Broad Institute Whole Genome Assembly Team;
RA Wade C.M., Giulotto E., Sigurdsson S., Zoli M., Gnerre S., Imsland F.,
RA Lear T.L., Adelson D.L., Bailey E., Bellone R.R., Bloecker H., Distl O.,
RA Edgar R.C., Garber M., Leeb T., Mauceli E., MacLeod J.N., Penedo M.C.T.,
RA Raison J.M., Sharpe T., Vogel J., Andersson L., Antczak D.F., Biagi T.,
RA Binns M.M., Chowdhary B.P., Coleman S.J., Della Valle G., Fryc S.,
RA Guerin G., Hasegawa T., Hill E.W., Jurka J., Kiialainen A., Lindgren G.,
RA Liu J., Magnani E., Mickelson J.R., Murray J., Nergadze S.G., Onofrio R.,
RA Pedroni S., Piras M.F., Raudsepp T., Rocchi M., Roeed K.H., Ryder O.A.,
RA Searle S., Skow L., Swinburne J.E., Syvaenen A.C., Tozaki T., Valberg S.J.,
RA Vaudin M., White J.R., Zody M.C., Lander E.S., Lindblad-Toh K.;
RT "Genome sequence, comparative analysis, and population genetics of the
RT domestic horse.";
RL Science 326:865-867(2009).
RN [2] {ECO:0000313|Ensembl:ENSECAP00000043311.1}
RP IDENTIFICATION.
RC STRAIN=Thoroughbred {ECO:0000313|Ensembl:ENSECAP00000043311.1};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
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DR AlphaFoldDB; A0A3Q2I5L3; -.
DR STRING; 9796.ENSECAP00000043311; -.
DR PaxDb; 9796-ENSECAP00000043311; -.
DR Ensembl; ENSECAT00000032240.2; ENSECAP00000043311.1; ENSECAG00000011734.4.
DR VGNC; VGNC:24567; TRPV4.
DR GeneTree; ENSGT00940000158615; -.
DR OMA; KVCNQDQ; -.
DR Proteomes; UP000002281; Chromosome 8.
DR Bgee; ENSECAG00000011734; Expressed in articular cartilage of joint and 12 other cell types or tissues.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005216; F:monoatomic ion channel activity; IEA:InterPro.
DR Gene3D; 1.10.287.70; -; 1.
DR Gene3D; 1.25.40.20; Ankyrin repeat-containing domain; 1.
DR InterPro; IPR002110; Ankyrin_rpt.
DR InterPro; IPR036770; Ankyrin_rpt-contain_sf.
DR InterPro; IPR005821; Ion_trans_dom.
DR InterPro; IPR024862; TRPV.
DR InterPro; IPR008347; TrpV1-4.
DR InterPro; IPR008348; TrpV4.
DR NCBIfam; TIGR00870; trp; 1.
DR PANTHER; PTHR10582:SF4; TRANSIENT RECEPTOR POTENTIAL CATION CHANNEL SUBFAMILY V MEMBER 4; 1.
DR PANTHER; PTHR10582; TRANSIENT RECEPTOR POTENTIAL ION CHANNEL PROTEIN; 1.
DR Pfam; PF00023; Ank; 1.
DR Pfam; PF00520; Ion_trans; 1.
DR PRINTS; PR01768; TRPVRECEPTOR.
DR PRINTS; PR01769; VRL2RECEPTOR.
DR SMART; SM00248; ANK; 3.
DR SUPFAM; SSF48403; Ankyrin repeat; 1.
DR PROSITE; PS50297; ANK_REP_REGION; 1.
DR PROSITE; PS50088; ANK_REPEAT; 1.
PE 4: Predicted;
KW ANK repeat {ECO:0000256|PROSITE-ProRule:PRU00023};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000002281};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 452..474
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 494..512
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 532..553
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 559..579
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 600..622
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 679..703
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT REPEAT 220..252
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT DOMAIN 461..715
FT /note="Ion transport"
FT /evidence="ECO:0000259|Pfam:PF00520"
FT REGION 1..68
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 833..857
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 857 AA; 95979 MW; 30E63EC0123F2E00 CRC64;
MADPSEGPRT GSGEMAEAPG DESGIPGGEA FPLSSLANLF EGEDGSPSHS PNDTGRPAGP
SDGRPNLRMK FQGAFRKGVP NPIDLLESTL YESSVVPGPK KAPMDSLFDY GTYRHHPSDN
KRWRKKVIDL PWPQSPLPLQ PHLLSVMVHP LLPLSPLSLP PSACTSLPAE PSTGKTCLPK
ALLNLSHGHN NTIPVLLDIA ERTGNMREFI NSPFRDIYYR GQTALHIAIE RRCKHYVELL
VAQGADVHAQ ARGRFFQPKD EGGYFYFGEL PLSLAACTNQ PHIVNYLTEN PHKKADMRRQ
DSRGNTVLHA LVAIADNTRE NTKFVTKMYD LLLLKCARLF PDSNLEAVLN NDGLSPLMMA
AKTGKIGVFQ HIIRREVTDE DTRHLSRKFK DWAYGPVYSS LYDLSSLDTC GEEASVLEIL
VYNSKIENRH EMLAVEPINE LLRDKWRKFG AVSFYINVVS YLCAMVIFTL TAYYQPLEGT
PPYPYRTTVD YLRLAGEIIT LFTGVLFFFT NVSAWPPTPP ACPASLSPLP PLVVSAALSF
IYSVLVIVSA ALYLAGIEAY LAVMVFALVL GWMNALYFTR GLKLTGTYSI MIQKILFKDL
FRFLLVYLLF MIGYASALVS LLNPCANMKV CNEDHTNCTV PTYPSCRDSE TFSTFLLDLF
KLTIGMGDLE MLSSTKYPVV FIILLVTYII LTFVLLLNML IALMGETVGQ VSKESKHIWK
LQWATTILDI ERSFPVFLRK AFRSGEMVTV GKSSDGTPDR RWCFRVDEVN WSHWNQNLGI
INEDPGKNES YQYYGFSHTV GRLRRDRWSS VVPRVVELNK NSNPDEVVVP LDNMGNPSCD
GHQQSYPPKW RTDDAPL
//
