ID A0A3Q2I648_HORSE Unreviewed; 1549 AA.
AC A0A3Q2I648;
DT 10-APR-2019, integrated into UniProtKB/TrEMBL.
DT 13-SEP-2023, sequence version 2.
DT 27-MAR-2024, entry version 24.
DE SubName: Full=Regulating synaptic membrane exocytosis 2 {ECO:0000313|Ensembl:ENSECAP00000042778.2};
GN Name=RIMS2 {ECO:0000313|VGNC:VGNC:56304};
OS Equus caballus (Horse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Perissodactyla; Equidae; Equus.
OX NCBI_TaxID=9796 {ECO:0000313|Ensembl:ENSECAP00000042778.2, ECO:0000313|Proteomes:UP000002281};
RN [1] {ECO:0000313|Ensembl:ENSECAP00000042778.2, ECO:0000313|Proteomes:UP000002281}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Thoroughbred {ECO:0000313|Ensembl:ENSECAP00000042778.2,
RC ECO:0000313|Proteomes:UP000002281};
RX PubMed=19892987; DOI=10.1126/science.1178158;
RG Broad Institute Genome Sequencing Platform;
RG Broad Institute Whole Genome Assembly Team;
RA Wade C.M., Giulotto E., Sigurdsson S., Zoli M., Gnerre S., Imsland F.,
RA Lear T.L., Adelson D.L., Bailey E., Bellone R.R., Bloecker H., Distl O.,
RA Edgar R.C., Garber M., Leeb T., Mauceli E., MacLeod J.N., Penedo M.C.T.,
RA Raison J.M., Sharpe T., Vogel J., Andersson L., Antczak D.F., Biagi T.,
RA Binns M.M., Chowdhary B.P., Coleman S.J., Della Valle G., Fryc S.,
RA Guerin G., Hasegawa T., Hill E.W., Jurka J., Kiialainen A., Lindgren G.,
RA Liu J., Magnani E., Mickelson J.R., Murray J., Nergadze S.G., Onofrio R.,
RA Pedroni S., Piras M.F., Raudsepp T., Rocchi M., Roeed K.H., Ryder O.A.,
RA Searle S., Skow L., Swinburne J.E., Syvaenen A.C., Tozaki T., Valberg S.J.,
RA Vaudin M., White J.R., Zody M.C., Lander E.S., Lindblad-Toh K.;
RT "Genome sequence, comparative analysis, and population genetics of the
RT domestic horse.";
RL Science 326:865-867(2009).
RN [2] {ECO:0000313|Ensembl:ENSECAP00000042778.2}
RP IDENTIFICATION.
RC STRAIN=Thoroughbred {ECO:0000313|Ensembl:ENSECAP00000042778.2};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR Ensembl; ENSECAT00000055456.2; ENSECAP00000042778.2; ENSECAG00000023008.4.
DR VGNC; VGNC:56304; RIMS2.
DR GeneTree; ENSGT00940000155236; -.
DR InParanoid; A0A3Q2I648; -.
DR OMA; MDRPDMR; -.
DR Proteomes; UP000002281; Chromosome 9.
DR Bgee; ENSECAG00000023008; Expressed in brainstem and 9 other cell types or tissues.
DR GO; GO:0048788; C:cytoskeleton of presynaptic active zone; IBA:GO_Central.
DR GO; GO:0042734; C:presynaptic membrane; IBA:GO_Central.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0031267; F:small GTPase binding; IEA:InterPro.
DR GO; GO:0044325; F:transmembrane transporter binding; IBA:GO_Central.
DR GO; GO:0048791; P:calcium ion-regulated exocytosis of neurotransmitter; IBA:GO_Central.
DR GO; GO:0050806; P:positive regulation of synaptic transmission; IBA:GO_Central.
DR GO; GO:0042391; P:regulation of membrane potential; IBA:GO_Central.
DR GO; GO:0048167; P:regulation of synaptic plasticity; IBA:GO_Central.
DR GO; GO:2000300; P:regulation of synaptic vesicle exocytosis; IBA:GO_Central.
DR CDD; cd04031; C2A_RIM1alpha; 1.
DR CDD; cd04028; C2B_RIM1alpha; 1.
DR CDD; cd00992; PDZ_signaling; 1.
DR Gene3D; 2.30.42.10; -; 1.
DR Gene3D; 2.60.40.150; C2 domain; 2.
DR Gene3D; 3.30.40.10; Zinc/RING finger domain, C3HC4 (zinc finger); 1.
DR InterPro; IPR000008; C2_dom.
DR InterPro; IPR035892; C2_domain_sf.
DR InterPro; IPR041282; FYVE_2.
DR InterPro; IPR001478; PDZ.
DR InterPro; IPR041489; PDZ_6.
DR InterPro; IPR036034; PDZ_sf.
DR InterPro; IPR039032; Rim-like.
DR InterPro; IPR017455; Znf_FYVE-rel.
DR InterPro; IPR011011; Znf_FYVE_PHD.
DR InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR PANTHER; PTHR12157; REGULATING SYNAPTIC MEMBRANE EXOCYTOSIS PROTEIN; 1.
DR PANTHER; PTHR12157:SF15; REGULATING SYNAPTIC MEMBRANE EXOCYTOSIS PROTEIN 2; 1.
DR Pfam; PF00168; C2; 2.
DR Pfam; PF02318; FYVE_2; 1.
DR Pfam; PF17820; PDZ_6; 1.
DR SMART; SM00239; C2; 2.
DR SMART; SM00228; PDZ; 1.
DR SUPFAM; SSF49562; C2 domain (Calcium/lipid-binding domain, CaLB); 2.
DR SUPFAM; SSF57903; FYVE/PHD zinc finger; 1.
DR SUPFAM; SSF50156; PDZ domain-like; 1.
DR PROSITE; PS50004; C2; 2.
DR PROSITE; PS50106; PDZ; 1.
DR PROSITE; PS50178; ZF_FYVE; 1.
PE 4: Predicted;
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Reference proteome {ECO:0000313|Proteomes:UP000002281};
KW Synapse {ECO:0000256|ARBA:ARBA00023018};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW ProRule:PRU00091}.
FT DOMAIN 12..68
FT /note="FYVE-type"
FT /evidence="ECO:0000259|PROSITE:PS50178"
FT DOMAIN 516..602
FT /note="PDZ"
FT /evidence="ECO:0000259|PROSITE:PS50106"
FT DOMAIN 653..776
FT /note="C2"
FT /evidence="ECO:0000259|PROSITE:PS50004"
FT DOMAIN 1395..1513
FT /note="C2"
FT /evidence="ECO:0000259|PROSITE:PS50004"
FT REGION 80..462
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 610..640
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 789..820
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 876..1230
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1306..1326
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 93..111
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 137..152
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 154..184
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 199..260
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 277..301
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 308..338
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 339..360
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 368..405
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 433..448
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 614..640
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 801..820
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 878..905
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 906..960
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 961..1005
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1022..1069
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1078..1096
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1101..1138
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1140..1230
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1549 AA; 174981 MW; 5106E8F23A060288 CRC64;
MGEESQQQQE QKGDAPTCGI CHKTKFADGC GHNCSYCQTK FCARCGGRVS LRSNKVMWVC
NLCRKQQEIL TKSGAWFYNS GSNTPQQPDQ KVLRGLRNEE APQEKKAKLH EQAQFQGPSG
DLSVPAVEKS RSHGLTRQDS IKNGSGVTHQ IASDIASDRK RSPSVSRDQN RRYDQREERE
EYSQYATSDS AMPRSPSDYA DRRSQHEPQF YEESDNINYR DSNRRSHRHS KEYIADDEDV
ESRDEYERQR REEEYQARYR SDPNLARYPV KPQPYEEQMR IHAEVSRARH ERRHSDVSLA
NAELEDSRIS MLRMERPSRQ RSISERRAAL ENQRSYSMER TREAQGPSSY PQRTTNHSPP
TPRRSPIPID RPDLRRTDSL RKQHHLDPSS AVRKTKREKM ETMLRNDSLS SDQSESVRPP
PPKPHKSKKG GKMRQVSLSS SEEELASTPE YTSCDDVEIE SESVSEKGDM DYNWLDHTSW
HSSEASPMSL HPVTWQPSKD GDRLIGRILL NKRLKDGSVP RDSGAMLGLK VVGGKMTESG
RLCAFITKVK KGSLADTVGH LRPGDEVLEW NGRPLQGATF EEVYNIILES KPEPQVELVV
SRPIGDIPRI PDSTHAQLES SSSSFESQKM DRPSISVTSP MSPGMLRDVP QFLSGQLSIK
LWFDKVGHQL IVTILGAKDL PSREDGRPRN PYVKIYFLPD RSDKNKRRTK TVKKTLEPKW
NQTFIYSPVH RREFRERMLE ITLWDQARVR EEESEFLGEI LIELETALLD DEPHWYKLQT
HDVSSLPLPH PSPYMPRRQL HGESPTRRLQ RSKRISDSEV SDYDCDDGIG VVSDYRHNGR
DLQSSTLSVP EQVMSSNHCS LSGSPHRVDV IGRTRSWSPS VPPPQSRNVE QGLRGTRSAT
GHYNTISRMD RHRVMDDHYS PDRDRDCEAA DRQPYHRSRS TEQRPLLERT TTRSRSTERP
DTNLMRSMPS LMTGRSAPPS PALSRSHPRT GSVQTSPSST PVAGRRGRQL PQLPPKGTLE
RNNGVKEIEP YEDVNEETGH VEEQGGEKQG EEVKAGAMDI EERNRQMKIN KYKQVAGSDS
RLEQDYHSKY RSGWDPHRGA DNISTKSSDS DVSDISAVSR TSSASRFSST SYMSVQSERP
RGNKKIRPKG IAEGGKEGDQ HEEIVHEEEE VKEERTNENG EEKEITKTCN KERSRESGDE
GKTQDVPEQG KEKEQWDKKD LQRRFSQDDD SVFTSKMQSR QMGISGKNMT KSTSISGDMC
SLEKNDGSQS DTAVGALGSS GKKRRSSIGA KMVAIVGLSR KSRSASQLSQ TEAGGKKLRS
TVQRSTETGL AVEMRNWMTR QASRESTDGS MNSYSSEGNL IFPGVRLASD SQFSDFLDGL
GPAQLVGRQT LATPAMGDIQ VGMMDKKGQL EVEIIRARGL VVKPGSKTLP APYVKVYLLD
NGVCIAKKKT KVARKTLEPL YQQLLSFEES PQGKVLQIIV WGDYGRMDHK SFMGVAQILL
DELELSNMVI GWFKLFPPSS LVDPTLAPLT RRASQSSLES STGPSYSRS
//
