ID A0A3Q2I6G4_HORSE Unreviewed; 1025 AA.
AC A0A3Q2I6G4;
DT 10-APR-2019, integrated into UniProtKB/TrEMBL.
DT 13-SEP-2023, sequence version 2.
DT 27-MAR-2024, entry version 26.
DE RecName: Full=Structural maintenance of chromosomes protein 5 {ECO:0000256|ARBA:ARBA00018687};
GN Name=SMC5 {ECO:0000313|Ensembl:ENSECAP00000043495.2,
GN ECO:0000313|VGNC:VGNC:23333};
OS Equus caballus (Horse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Perissodactyla; Equidae; Equus.
OX NCBI_TaxID=9796 {ECO:0000313|Ensembl:ENSECAP00000043495.2, ECO:0000313|Proteomes:UP000002281};
RN [1] {ECO:0000313|Ensembl:ENSECAP00000043495.2, ECO:0000313|Proteomes:UP000002281}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Thoroughbred {ECO:0000313|Ensembl:ENSECAP00000043495.2,
RC ECO:0000313|Proteomes:UP000002281};
RX PubMed=19892987; DOI=10.1126/science.1178158;
RG Broad Institute Genome Sequencing Platform;
RG Broad Institute Whole Genome Assembly Team;
RA Wade C.M., Giulotto E., Sigurdsson S., Zoli M., Gnerre S., Imsland F.,
RA Lear T.L., Adelson D.L., Bailey E., Bellone R.R., Bloecker H., Distl O.,
RA Edgar R.C., Garber M., Leeb T., Mauceli E., MacLeod J.N., Penedo M.C.T.,
RA Raison J.M., Sharpe T., Vogel J., Andersson L., Antczak D.F., Biagi T.,
RA Binns M.M., Chowdhary B.P., Coleman S.J., Della Valle G., Fryc S.,
RA Guerin G., Hasegawa T., Hill E.W., Jurka J., Kiialainen A., Lindgren G.,
RA Liu J., Magnani E., Mickelson J.R., Murray J., Nergadze S.G., Onofrio R.,
RA Pedroni S., Piras M.F., Raudsepp T., Rocchi M., Roeed K.H., Ryder O.A.,
RA Searle S., Skow L., Swinburne J.E., Syvaenen A.C., Tozaki T., Valberg S.J.,
RA Vaudin M., White J.R., Zody M.C., Lander E.S., Lindblad-Toh K.;
RT "Genome sequence, comparative analysis, and population genetics of the
RT domestic horse.";
RL Science 326:865-867(2009).
RN [2] {ECO:0000313|Ensembl:ENSECAP00000043495.2}
RP IDENTIFICATION.
RC STRAIN=Thoroughbred {ECO:0000313|Ensembl:ENSECAP00000043495.2};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Chromosome {ECO:0000256|ARBA:ARBA00004286}.
CC Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC -!- SIMILARITY: Belongs to the SMC family. SMC5 subfamily.
CC {ECO:0000256|ARBA:ARBA00010171}.
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DR AlphaFoldDB; A0A3Q2I6G4; -.
DR Ensembl; ENSECAT00000060212.2; ENSECAP00000043495.2; ENSECAG00000024999.4.
DR VGNC; VGNC:23333; SMC5.
DR GeneTree; ENSGT01100000263674; -.
DR Proteomes; UP000002281; Chromosome 23.
DR Bgee; ENSECAG00000024999; Expressed in oviduct epithelium and 23 other cell types or tissues.
DR ExpressionAtlas; A0A3Q2I6G4; baseline.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0030915; C:Smc5-Smc6 complex; IEA:InterPro.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR GO; GO:0000724; P:double-strand break repair via homologous recombination; IEA:InterPro.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR003395; RecF/RecN/SMC_N.
DR InterPro; IPR027131; SMC5.
DR PANTHER; PTHR45916; STRUCTURAL MAINTENANCE OF CHROMOSOMES PROTEIN 5; 1.
DR PANTHER; PTHR45916:SF1; STRUCTURAL MAINTENANCE OF CHROMOSOMES PROTEIN 5; 1.
DR Pfam; PF02463; SMC_N; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 2.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Chromosome {ECO:0000256|ARBA:ARBA00022454};
KW Coiled coil {ECO:0000256|SAM:Coils};
KW DNA recombination {ECO:0000256|ARBA:ARBA00023172};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000002281}.
FT DOMAIN 54..1023
FT /note="RecF/RecN/SMC N-terminal"
FT /evidence="ECO:0000259|Pfam:PF02463"
FT REGION 1..47
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 237..452
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 653..711
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 891..928
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 1025 AA; 119854 MW; 81234C11BB8E19BC CRC64;
MATPSRKTST PGPLASKRPL PRDPSSEVPS KRKSSAPPAP RPLQSSGPFV EGSIVRIAME
NFLTYDVCEV APGPHLNMII GANGTGKSSI VCAICLGLAG KPAFMGRADK VGFFVKRGCS
KGMVEIELFR TSGNLVITRE IDVAKNQSFW FINKKSTTQK VVEEQVAALN IQVGNLCQFL
PQDKVGEFAK LSKIELLEAT EKSIGPPEMH RYHCELKNFR EKEKQLETSC KEKTEYLEKM
IQRNERYKQD VERFYERKRH LDLIEMLEAK RPWVEYENVR QEYEEVKLAR DRVKEEVRKL
KEGQIPMTLR IEEIEKQRHN LEARIKEKAT DIKETSQKCK QRQDVIERKD KHIEELQQAL
TVKRNEEHDR QRRISNTRKM IEDLQNELKT TENCENLQPQ IDAITNDLRR VQDEKALCEG
EIIDKRREKE TLEKEKKNVE EHIVRFDNLM NQKEDKLRQR YRDTYDAVLW LRNNRNKFKQ
RVCEPIMLTI NMKDNKNAKY VENHIPLNDL RAFVFESQED MEVFLREVRD NKKLRVNAVV
APRVSHADRA PSRSLNELKP YGFFSYLREL FDAPDPVMSY LCCQYHIHEV PVGTERTRER
IERVIQETRL KQIYTAEEKY VVKTSFYSNK VISINTSLKV AQFLTVTVDL EQRRHLEEQL
KEINKKLQAV ESDLIALHET NKRLEHKDNE LRQKKKELLE RKTKKRQLEQ KISSKLGSLK
LMEQDTCNLE EEERKASAKI KEIHVQKAKL VTELTDLIKS CTSLHIKKVD LILQNTTVIS
EKNKLESDYM AASSQLRVTE QHFIELDENR QRLLQKCKEL MKRARQVCNL GAEQTVPQEY
QTQVPTIPNG HNSSPPMAFQ DLPNTLDEID ALLTEERSRA SCFTGLNPTV VEEYTKREEE
IEQLTEELKI KKVELDQYRE SISQVKERWL NPLKELVEKI NEKFSNFFSS MQCAGEVDLH
TENEEDYDKY GIRIRVKFRS STQLHELTPH HQSGGERSVS TMLYLMALQE LNRCPFRVVD
EINQV
//
