ID A0A3Q2I7N2_HORSE Unreviewed; 997 AA.
AC A0A3Q2I7N2;
DT 10-APR-2019, integrated into UniProtKB/TrEMBL.
DT 13-SEP-2023, sequence version 3.
DT 27-MAR-2024, entry version 26.
DE RecName: Full=ferroxidase {ECO:0000256|ARBA:ARBA00013107};
DE EC=1.16.3.1 {ECO:0000256|ARBA:ARBA00013107};
GN Name=CPHL1 {ECO:0000313|Ensembl:ENSECAP00000043985.3,
GN ECO:0000313|VGNC:VGNC:108997};
OS Equus caballus (Horse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Perissodactyla; Equidae; Equus.
OX NCBI_TaxID=9796 {ECO:0000313|Ensembl:ENSECAP00000043985.3, ECO:0000313|Proteomes:UP000002281};
RN [1] {ECO:0000313|Ensembl:ENSECAP00000043985.3, ECO:0000313|Proteomes:UP000002281}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Thoroughbred {ECO:0000313|Ensembl:ENSECAP00000043985.3,
RC ECO:0000313|Proteomes:UP000002281};
RX PubMed=19892987; DOI=10.1126/science.1178158;
RG Broad Institute Genome Sequencing Platform;
RG Broad Institute Whole Genome Assembly Team;
RA Wade C.M., Giulotto E., Sigurdsson S., Zoli M., Gnerre S., Imsland F.,
RA Lear T.L., Adelson D.L., Bailey E., Bellone R.R., Bloecker H., Distl O.,
RA Edgar R.C., Garber M., Leeb T., Mauceli E., MacLeod J.N., Penedo M.C.T.,
RA Raison J.M., Sharpe T., Vogel J., Andersson L., Antczak D.F., Biagi T.,
RA Binns M.M., Chowdhary B.P., Coleman S.J., Della Valle G., Fryc S.,
RA Guerin G., Hasegawa T., Hill E.W., Jurka J., Kiialainen A., Lindgren G.,
RA Liu J., Magnani E., Mickelson J.R., Murray J., Nergadze S.G., Onofrio R.,
RA Pedroni S., Piras M.F., Raudsepp T., Rocchi M., Roeed K.H., Ryder O.A.,
RA Searle S., Skow L., Swinburne J.E., Syvaenen A.C., Tozaki T., Valberg S.J.,
RA Vaudin M., White J.R., Zody M.C., Lander E.S., Lindblad-Toh K.;
RT "Genome sequence, comparative analysis, and population genetics of the
RT domestic horse.";
RL Science 326:865-867(2009).
RN [2] {ECO:0000313|Ensembl:ENSECAP00000043985.3}
RP IDENTIFICATION.
RC STRAIN=Thoroughbred {ECO:0000313|Ensembl:ENSECAP00000043985.3};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=4 Fe(2+) + 4 H(+) + O2 = 4 Fe(3+) + 2 H2O;
CC Xref=Rhea:RHEA:11148, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378,
CC ChEBI:CHEBI:15379, ChEBI:CHEBI:29033, ChEBI:CHEBI:29034; EC=1.16.3.1;
CC Evidence={ECO:0000256|ARBA:ARBA00001830};
CC -!- SIMILARITY: Belongs to the multicopper oxidase family.
CC {ECO:0000256|ARBA:ARBA00010609}.
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DR AlphaFoldDB; A0A3Q2I7N2; -.
DR STRING; 9796.ENSECAP00000043985; -.
DR PaxDb; 9796-ENSECAP00000043985; -.
DR Ensembl; ENSECAT00000054138.3; ENSECAP00000043985.3; ENSECAG00000040185.3.
DR VGNC; VGNC:108997; CPHL1.
DR GeneTree; ENSGT00940000165295; -.
DR InParanoid; A0A3Q2I7N2; -.
DR Proteomes; UP000002281; Chromosome 16.
DR Bgee; ENSECAG00000040185; Expressed in articular cartilage of joint and 10 other cell types or tissues.
DR ExpressionAtlas; A0A3Q2I7N2; baseline.
DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR GO; GO:0005507; F:copper ion binding; IEA:InterPro.
DR GO; GO:0016491; F:oxidoreductase activity; IBA:GO_Central.
DR GO; GO:0006825; P:copper ion transport; IEA:UniProtKB-KW.
DR GO; GO:0006826; P:iron ion transport; IBA:GO_Central.
DR Gene3D; 2.60.40.420; Cupredoxins - blue copper proteins; 5.
DR InterPro; IPR011707; Cu-oxidase-like_N.
DR InterPro; IPR001117; Cu-oxidase_2nd.
DR InterPro; IPR011706; Cu-oxidase_C.
DR InterPro; IPR033138; Cu_oxidase_CS.
DR InterPro; IPR002355; Cu_oxidase_Cu_BS.
DR InterPro; IPR008972; Cupredoxin.
DR PANTHER; PTHR46806:SF7; COAGULATION FACTOR VIII; 1.
DR PANTHER; PTHR46806; F5/8 TYPE C DOMAIN-CONTAINING PROTEIN; 1.
DR Pfam; PF00394; Cu-oxidase; 1.
DR Pfam; PF07731; Cu-oxidase_2; 1.
DR Pfam; PF07732; Cu-oxidase_3; 3.
DR SUPFAM; SSF49503; Cupredoxins; 6.
DR PROSITE; PS00079; MULTICOPPER_OXIDASE1; 1.
DR PROSITE; PS00080; MULTICOPPER_OXIDASE2; 1.
PE 3: Inferred from homology;
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Oxidoreductase {ECO:0000256|ARBA:ARBA00023002};
KW Reference proteome {ECO:0000313|Proteomes:UP000002281}.
FT DOMAIN 50..156
FT /note="Plastocyanin-like"
FT /evidence="ECO:0000259|Pfam:PF07732"
FT DOMAIN 180..298
FT /note="Plastocyanin-like"
FT /evidence="ECO:0000259|Pfam:PF00394"
FT DOMAIN 396..503
FT /note="Plastocyanin-like"
FT /evidence="ECO:0000259|Pfam:PF07732"
FT DOMAIN 750..844
FT /note="Plastocyanin-like"
FT /evidence="ECO:0000259|Pfam:PF07732"
FT DOMAIN 893..995
FT /note="Plastocyanin-like"
FT /evidence="ECO:0000259|Pfam:PF07731"
SQ SEQUENCE 997 AA; 113155 MW; E4C4058F2A5101C8 CRC64;
MFIFYRDYQS QTYLRQGRDR IGPVYKKALY FQYADDTFQA IIEKPSWLGF LGPIIKAETG
DFIYVQVKNF ASRIYGFHPH GVSYTKENEG ALYPDNTTAL QKKDDRLEPG KQYTYKWHVE
ENQGPGPNDS NCVTRIYHSH IVTPKDVASG LIGPILTCKR GTLDGDVEKN IDRSYVLLFS
TTDENSSWYI DDNIKTYTES GQVNSSDPGF QESNRMSSIN GYMYGNLPNL TMCAEDKVKW
YFVGMGDGSD MHPIYLHGQT LISRNHRKDT ITIFPASLVD AFMVAKGPGE WMLDCQVHEA
MQAFFSVRNC QKPSTDLTGT RVVRYYIAAE EISWNYAPSG IDFFTKKNLT AAGSESQPYF
EQSPTRIGGT YKKLVYREYT DASFRTQKAR AEHLGILGPV IKAEVGQIIE VTFYNNASLP
LSIHPHGLRY NKSNEGSFYR TPGGGAPPPS SHVNPGTTFV YTWEVPRDVG PTSTDPNCLT
WLYYSSVNGT RDTHSGLVGP LLVCRNGSLG DEGKQKGIDK EFYLLATIFD ENESFLLDKN
IRAFTTEPEN VDKEDPGFQN SNMMYTLNGY MYGNLPGLDM CLGDNVSWHV LSVGSVSDLH
GIYFSGNTFT SLGAREDTLA VFPHTSQTLL MTPDSTGIFD VVCMTAEHYT GGMKDKYRVR
ECLEPSPDQT QYQEEKTIYI AAEEIVWDYS PSRKWEKELH RLQGENKTNI YLDRIGMFLG
SKYKKVVYRQ YDDITFTNQT KRNEDEKHLD MLGPLIFLNP GQKLQIIFKN NASRPYSIHA
HGVKTNSSTV APTQPGEIQT YVWQVPERTG PTSKDFECIP WFYYSTVDVV KDLNSGLIGP
LIVCRRDAKA SIVHRVLHFK TFDENESWYF EENINTYALD PSQVDRNDDS FFFSNLMHAI
NGRLFGNNQG LTLHVGDEVN WYLIGMGSAF DLHTVHFHGH SFDYTDSGIY RSDVYDLPPG
VYKTVKMYPR DVGTWLFHCH VGLHIEGGME STYTVIE
//
