ID A0A3Q2I8X6_HORSE Unreviewed; 1631 AA.
AC A0A3Q2I8X6;
DT 10-APR-2019, integrated into UniProtKB/TrEMBL.
DT 13-SEP-2023, sequence version 2.
DT 27-MAR-2024, entry version 24.
DE SubName: Full=Eukaryotic translation initiation factor 4 gamma 3 {ECO:0000313|Ensembl:ENSECAP00000043879.2};
GN Name=EIF4G3 {ECO:0000313|VGNC:VGNC:17508};
OS Equus caballus (Horse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Perissodactyla; Equidae; Equus.
OX NCBI_TaxID=9796 {ECO:0000313|Ensembl:ENSECAP00000043879.2, ECO:0000313|Proteomes:UP000002281};
RN [1] {ECO:0000313|Ensembl:ENSECAP00000043879.2, ECO:0000313|Proteomes:UP000002281}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Thoroughbred {ECO:0000313|Ensembl:ENSECAP00000043879.2,
RC ECO:0000313|Proteomes:UP000002281};
RX PubMed=19892987; DOI=10.1126/science.1178158;
RG Broad Institute Genome Sequencing Platform;
RG Broad Institute Whole Genome Assembly Team;
RA Wade C.M., Giulotto E., Sigurdsson S., Zoli M., Gnerre S., Imsland F.,
RA Lear T.L., Adelson D.L., Bailey E., Bellone R.R., Bloecker H., Distl O.,
RA Edgar R.C., Garber M., Leeb T., Mauceli E., MacLeod J.N., Penedo M.C.T.,
RA Raison J.M., Sharpe T., Vogel J., Andersson L., Antczak D.F., Biagi T.,
RA Binns M.M., Chowdhary B.P., Coleman S.J., Della Valle G., Fryc S.,
RA Guerin G., Hasegawa T., Hill E.W., Jurka J., Kiialainen A., Lindgren G.,
RA Liu J., Magnani E., Mickelson J.R., Murray J., Nergadze S.G., Onofrio R.,
RA Pedroni S., Piras M.F., Raudsepp T., Rocchi M., Roeed K.H., Ryder O.A.,
RA Searle S., Skow L., Swinburne J.E., Syvaenen A.C., Tozaki T., Valberg S.J.,
RA Vaudin M., White J.R., Zody M.C., Lander E.S., Lindblad-Toh K.;
RT "Genome sequence, comparative analysis, and population genetics of the
RT domestic horse.";
RL Science 326:865-867(2009).
RN [2] {ECO:0000313|Ensembl:ENSECAP00000043879.2}
RP IDENTIFICATION.
RC STRAIN=Thoroughbred {ECO:0000313|Ensembl:ENSECAP00000043879.2};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the eukaryotic initiation factor 4G family.
CC {ECO:0000256|ARBA:ARBA00005775}.
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DR Ensembl; ENSECAT00000044039.3; ENSECAP00000043879.2; ENSECAG00000011147.4.
DR VGNC; VGNC:17508; EIF4G3.
DR GeneTree; ENSGT00940000156454; -.
DR Proteomes; UP000002281; Chromosome 2.
DR Bgee; ENSECAG00000011147; Expressed in prefrontal cortex and 23 other cell types or tissues.
DR ExpressionAtlas; A0A3Q2I8X6; baseline.
DR GO; GO:0003723; F:RNA binding; IEA:InterPro.
DR GO; GO:0003743; F:translation initiation factor activity; IEA:UniProtKB-KW.
DR CDD; cd11559; W2_eIF4G1_like; 1.
DR Gene3D; 1.25.40.180; -; 3.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR045208; IF4G.
DR InterPro; IPR003891; Initiation_fac_eIF4g_MI.
DR InterPro; IPR003890; MIF4G-like_typ-3.
DR InterPro; IPR003307; W2_domain.
DR PANTHER; PTHR23253; EUKARYOTIC TRANSLATION INITIATION FACTOR 4 GAMMA; 1.
DR PANTHER; PTHR23253:SF23; EUKARYOTIC TRANSLATION INITIATION FACTOR 4 GAMMA 3; 1.
DR Pfam; PF02847; MA3; 1.
DR Pfam; PF02854; MIF4G; 1.
DR Pfam; PF02020; W2; 1.
DR SMART; SM00515; eIF5C; 1.
DR SMART; SM00544; MA3; 1.
DR SMART; SM00543; MIF4G; 1.
DR SUPFAM; SSF48371; ARM repeat; 3.
DR PROSITE; PS51366; MI; 1.
DR PROSITE; PS51363; W2; 1.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000002281}.
FT DOMAIN 1267..1389
FT /note="MI"
FT /evidence="ECO:0000259|PROSITE:PS51366"
FT DOMAIN 1462..1631
FT /note="W2"
FT /evidence="ECO:0000259|PROSITE:PS51363"
FT REGION 172..235
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 253..321
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 349..371
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 532..664
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 731..756
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1062..1087
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1117..1136
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1141..1269
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 181..197
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 216..232
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 353..371
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 553..621
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1141..1172
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1187..1207
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1233..1247
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1631 AA; 181815 MW; 0BEF4CF5FAE3E4E8 CRC64;
MNSQPQTRSP PSRTVPIHCT DNWKRRKVLE QTPVYRSLAG RGWIKYCIGG FRPIQFFQRP
QIQPPRATIP NSSPSIRPGA QTPTAVYQAN QHIMMVNHLP MPYPVPQGPQ YCIPQYRHSG
PPYVGPPQQY PVQPPGPGPF YPGPGPGDFP NAYGTPFYPS QPVYQSAPII VPTQQQPPPA
KREKKTIRIR DPNQGGKDIT EEIMSGGGSR NPTPPIGRPT STPTPPQQLP SQVPEHSPVV
YGTVESAHLA ASTPVTAASD QKQEEKPKPD PVLKSPSPVL RLVLSGEKKE QAGQTSETTA
VESIPELPLP PSPTTVSPLA RSTIASPTSA ALSSQPILTT AIDDRCELSS SKEDTIPVPS
PASCTETSDP SPTDIIDDDI CKKSCSVAPN DSPLIVSTNL INEMNGVSEK LPATESIVEI
VKQEVLPLTL ELEILQSPPE EMKVECVPAP ITRSTVPSFS PSPPTPPVSP PLTPVIIAAA
TTNVNTASAP TAVQRVLEED ENIRTCLSED APEIQNKIEV EADEQMEEIV DSQNLSSRKS
PVPAQTAITA PKMWKKPKDR TRTTEEVLEA ESEPKAEEEL SGDKVLDSEQ DKMSQGFHPE
RDPSDLKKVK ALEENGEEAE PVRNGAESVS EGEGIDANSG STDSSGDGVP FPFKPESWKP
ADTEGKKQYD REFLLDFQFM PACIQKPEGL PPISDVVLDK INQPKLPMRT LDPRILPRGP
DFTPAFADFG RQTPGGRGVP LLNVGPRRSQ PSQRREPRKI ITVPVKEDVH LKKAENAWKP
SQKRDIQAED PENIKTQELF RKVRSILNKL TPQMFNQLMK QVSGLTVDTE ERLKGVIDLV
FEKAIDEPSF SVAYANMCRC LVTLKVPMAD KPGNTVNFRK LLLNRCQKEF EKDKADDDVF
EKKQKELEAA SAPEERTRLH DELEEAKDRA RRRSIGNIKF IGELFKLKML TEAIMHDCVV
KLLKNHDEES LECLCRLLTT IGKDLDFEKA KPRMDQYFNQ MEKIVKERKT SSRIRFMLQD
VIDLRLCNWV SRRADQGPKT IEQIHKEAKI EEQEEQRKVQ QLMTKEKRRP GVQRVDEGGW
NTVQGAKNSR VLDPSKFLKI TKPTIDEKIQ LVPKAQLGSW GKGSSGGAKA SETDALRSSA
SSLNRFSALQ PPAPSGSASS TPLEFDSRRT LTSRGSMGRE KNDKPLPSAT TRPNTFMRGS
SSKDLLDNQS QEEQRREMLE TVKQLTGGMD VERSSTEADR SKTRESVAKS EIPATSASDK
PTLSEEEMER KSKSIIDEFL HINDFKEAMQ CVEELNAQGL LHVFVRMGVE STLERSQITR
DHMGQLLYQL VQSEKLSKQD FFKGFSETLE LADDMAIDIP HIWLYLAELV TPMLKEGGIS
MRELIIEFSK PLLPVGRAGI LLSEILHLLC KQMSHKKVGA VWREADLSWK DFLPEGEDVH
SFLLEQKLDF IESDSSCSSE ALSKKELSAE ELYKRLEKLI IEDKANDEQI FDWVEANLDE
SQMSSPTFLR ALMTAVCKAA IIADCSAFRV DTAVIKQRVP ILLKYLDSDT EKELQALYAL
QASIVKLDQP ANLLRMFFDC LYDEEVISED AFYKWESSKD PAEQNGKGVA LKSVTAFFTW
LREAEEESED N
//
