ID A0A3Q2I930_HORSE Unreviewed; 851 AA.
AC A0A3Q2I930;
DT 10-APR-2019, integrated into UniProtKB/TrEMBL.
DT 13-SEP-2023, sequence version 3.
DT 27-MAR-2024, entry version 25.
DE SubName: Full=L3MBTL histone methyl-lysine binding protein 1 {ECO:0000313|Ensembl:ENSECAP00000043944.3};
GN Name=L3MBTL1 {ECO:0000313|Ensembl:ENSECAP00000043944.3};
OS Equus caballus (Horse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Perissodactyla; Equidae; Equus.
OX NCBI_TaxID=9796 {ECO:0000313|Ensembl:ENSECAP00000043944.3, ECO:0000313|Proteomes:UP000002281};
RN [1] {ECO:0000313|Ensembl:ENSECAP00000043944.3, ECO:0000313|Proteomes:UP000002281}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Thoroughbred {ECO:0000313|Ensembl:ENSECAP00000043944.3,
RC ECO:0000313|Proteomes:UP000002281};
RX PubMed=19892987; DOI=10.1126/science.1178158;
RG Broad Institute Genome Sequencing Platform;
RG Broad Institute Whole Genome Assembly Team;
RA Wade C.M., Giulotto E., Sigurdsson S., Zoli M., Gnerre S., Imsland F.,
RA Lear T.L., Adelson D.L., Bailey E., Bellone R.R., Bloecker H., Distl O.,
RA Edgar R.C., Garber M., Leeb T., Mauceli E., MacLeod J.N., Penedo M.C.T.,
RA Raison J.M., Sharpe T., Vogel J., Andersson L., Antczak D.F., Biagi T.,
RA Binns M.M., Chowdhary B.P., Coleman S.J., Della Valle G., Fryc S.,
RA Guerin G., Hasegawa T., Hill E.W., Jurka J., Kiialainen A., Lindgren G.,
RA Liu J., Magnani E., Mickelson J.R., Murray J., Nergadze S.G., Onofrio R.,
RA Pedroni S., Piras M.F., Raudsepp T., Rocchi M., Roeed K.H., Ryder O.A.,
RA Searle S., Skow L., Swinburne J.E., Syvaenen A.C., Tozaki T., Valberg S.J.,
RA Vaudin M., White J.R., Zody M.C., Lander E.S., Lindblad-Toh K.;
RT "Genome sequence, comparative analysis, and population genetics of the
RT domestic horse.";
RL Science 326:865-867(2009).
RN [2] {ECO:0000313|Ensembl:ENSECAP00000043944.3}
RP IDENTIFICATION.
RC STRAIN=Thoroughbred {ECO:0000313|Ensembl:ENSECAP00000043944.3};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
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DR AlphaFoldDB; A0A3Q2I930; -.
DR STRING; 9796.ENSECAP00000043944; -.
DR PaxDb; 9796-ENSECAP00000043944; -.
DR Ensembl; ENSECAT00000051517.3; ENSECAP00000043944.3; ENSECAG00000008175.4.
DR GeneTree; ENSGT00940000159708; -.
DR InParanoid; A0A3Q2I930; -.
DR OMA; KECHSER; -.
DR Proteomes; UP000002281; Chromosome 22.
DR Bgee; ENSECAG00000008175; Expressed in liver and 21 other cell types or tissues.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0003682; F:chromatin binding; IBA:GO_Central.
DR GO; GO:0042393; F:histone binding; IBA:GO_Central.
DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR GO; GO:0045892; P:negative regulation of DNA-templated transcription; IBA:GO_Central.
DR CDD; cd20131; MBT_L3MBTL1_rpt1; 1.
DR CDD; cd20134; MBT_L3MBTL1_rpt2; 1.
DR CDD; cd20137; MBT_L3MBTL1_rpt3; 1.
DR Gene3D; 2.30.30.140; -; 3.
DR Gene3D; 4.10.320.30; -; 1.
DR Gene3D; 1.10.150.50; Transcription Factor, Ets-1; 1.
DR InterPro; IPR004092; Mbt.
DR InterPro; IPR047361; MBT_L3MBTL1_rpt1.
DR InterPro; IPR047362; MBT_L3MBTL1_rpt3.
DR InterPro; IPR013761; SAM/pointed_sf.
DR InterPro; IPR002515; Znf_C2H2C.
DR InterPro; IPR036060; Znf_C2H2C_sf.
DR PANTHER; PTHR12247:SF69; LETHAL(3)MALIGNANT BRAIN TUMOR-LIKE PROTEIN 1; 1.
DR PANTHER; PTHR12247; POLYCOMB GROUP PROTEIN; 1.
DR Pfam; PF02820; MBT; 3.
DR Pfam; PF01530; zf-C2HC; 1.
DR SMART; SM00561; MBT; 3.
DR SUPFAM; SSF103637; CCHHC domain; 1.
DR SUPFAM; SSF47769; SAM/Pointed domain; 1.
DR SUPFAM; SSF63748; Tudor/PWWP/MBT; 3.
DR PROSITE; PS51079; MBT; 3.
DR PROSITE; PS51802; ZF_CCHHC; 1.
PE 4: Predicted;
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000002281};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Transcription {ECO:0000256|ARBA:ARBA00023163};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW ProRule:PRU01143}.
FT REPEAT 287..387
FT /note="MBT"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00459"
FT REPEAT 395..494
FT /note="MBT"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00459"
FT REPEAT 503..598
FT /note="MBT"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00459"
FT REGION 136..287
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 206..224
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 226..259
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 263..282
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 851 AA; 93238 MW; 7176065A1E16F9C5 CRC64;
MEGHAEMEML RTLKGPSSGE VSVHLVARDS PASTATLGLS SSALDVSCFP REPIHVGAPE
RVADSVPVTA TVLPQLSAGP AASSSASTVR LLEWTEAAAP PPGSGLRFRI SEYAPLNMVG
AEQPPSPELR QEGVAEYENG EAPAGGGDAG THQPADLPQD PPEDPPQDPP EDDGTCQCQA
CGPQPGTGPD AGSSSDGCPP LYQERSVIVE NSSGQNSSCA STSELLKPMK KRKHREYQSP
SEEESEPEAM EKQEEGKDPE GQPTASTPES EEWSSSQPAS GEKKEGWSWE SYLEEQKAIT
APVSLFQDYQ TVTHNKNGFR LGMKLEGIDP QHPSMYFILS VAEVCGYRLR LHFDGYSECH
DFWINANSPD IHPAGWFEKT GHKLQPPKGY KEEEFSWSQY LRSTRAQAAP KHLFVSQSHS
PPPLGFQVGM KLEAVDRMNP SLVCVASVTD VVDSRFLVHF DNWDDTYDYW CDPSSPYIHP
VGWCQKQGKP LTPPQDYPDP DSFCWEKYLE ETGASAVPAW AFKVRPPHSF LVNMKLEAVD
RRNPALIRVA SVEDVEDHRI KLHFDGWSHA YDFWIDADHP DIHPAGWCSK TGHPLQPPLR
PREPSSASAG DCPPLSCQRL PHTRTSKYSF HHRKCPTPGC DGSGHVTGKF TAHHCLSGCP
LAERNQSRLK AELSDSEASA RKRNLSGFSL RKKPRHHGRC GGQGCRASCP PGPGQALSPC
HGPGPSLSRI GRPPKYQKIP QEDFPTLTTD VMHQSLFMSA LSAHPDRSLS VCWEQHCKLL
PGVAGISASA VTKWTIDEVF SFVQTLTGCE DQAQLFKDEA DIVKIMSVKL GPALKIYNAI
LMFKNADDTL K
//
