ID A0A3Q2I9S7_HORSE Unreviewed; 453 AA.
AC A0A3Q2I9S7;
DT 10-APR-2019, integrated into UniProtKB/TrEMBL.
DT 13-SEP-2023, sequence version 3.
DT 27-MAR-2024, entry version 17.
DE SubName: Full=Immunoglobulin heavy constant mu {ECO:0000313|Ensembl:ENSECAP00000042575.3};
GN Name=IGHM {ECO:0000313|Ensembl:ENSECAP00000042575.3};
OS Equus caballus (Horse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Perissodactyla; Equidae; Equus.
OX NCBI_TaxID=9796 {ECO:0000313|Ensembl:ENSECAP00000042575.3, ECO:0000313|Proteomes:UP000002281};
RN [1] {ECO:0000313|Ensembl:ENSECAP00000042575.3, ECO:0000313|Proteomes:UP000002281}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Thoroughbred {ECO:0000313|Ensembl:ENSECAP00000042575.3,
RC ECO:0000313|Proteomes:UP000002281};
RX PubMed=19892987; DOI=10.1126/science.1178158;
RG Broad Institute Genome Sequencing Platform;
RG Broad Institute Whole Genome Assembly Team;
RA Wade C.M., Giulotto E., Sigurdsson S., Zoli M., Gnerre S., Imsland F.,
RA Lear T.L., Adelson D.L., Bailey E., Bellone R.R., Bloecker H., Distl O.,
RA Edgar R.C., Garber M., Leeb T., Mauceli E., MacLeod J.N., Penedo M.C.T.,
RA Raison J.M., Sharpe T., Vogel J., Andersson L., Antczak D.F., Biagi T.,
RA Binns M.M., Chowdhary B.P., Coleman S.J., Della Valle G., Fryc S.,
RA Guerin G., Hasegawa T., Hill E.W., Jurka J., Kiialainen A., Lindgren G.,
RA Liu J., Magnani E., Mickelson J.R., Murray J., Nergadze S.G., Onofrio R.,
RA Pedroni S., Piras M.F., Raudsepp T., Rocchi M., Roeed K.H., Ryder O.A.,
RA Searle S., Skow L., Swinburne J.E., Syvaenen A.C., Tozaki T., Valberg S.J.,
RA Vaudin M., White J.R., Zody M.C., Lander E.S., Lindblad-Toh K.;
RT "Genome sequence, comparative analysis, and population genetics of the
RT domestic horse.";
RL Science 326:865-867(2009).
RN [2] {ECO:0000313|Ensembl:ENSECAP00000042575.3}
RP IDENTIFICATION.
RC STRAIN=Thoroughbred {ECO:0000313|Ensembl:ENSECAP00000042575.3};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR AlphaFoldDB; A0A3Q2I9S7; -.
DR Ensembl; ENSECAT00000052499.3; ENSECAP00000042575.3; ENSECAG00000000548.4.
DR GeneTree; ENSGT00940000161491; -.
DR Proteomes; UP000002281; Chromosome 24.
DR Bgee; ENSECAG00000003774; Expressed in bone marrow and 18 other cell types or tissues.
DR ExpressionAtlas; A0A3Q2I9S7; baseline.
DR CDD; cd21817; IgC1_CH1_IgEG; 1.
DR CDD; cd05768; IgC1_CH3_IgAGD_CH4_IgAEM; 1.
DR Gene3D; 2.60.40.10; Immunoglobulins; 3.
DR InterPro; IPR007110; Ig-like_dom.
DR InterPro; IPR036179; Ig-like_dom_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR003597; Ig_C1-set.
DR PANTHER; PTHR23411:SF39; IMMUNOGLOBULIN HEAVY CONSTANT GAMMA 1-RELATED; 1.
DR PANTHER; PTHR23411; TAPASIN; 1.
DR Pfam; PF07654; C1-set; 3.
DR SMART; SM00407; IGc1; 3.
DR SUPFAM; SSF48726; Immunoglobulin; 4.
DR PROSITE; PS50835; IG_LIKE; 3.
PE 1: Evidence at protein level;
KW Immunoglobulin domain {ECO:0000256|ARBA:ARBA00023319};
KW Proteomics identification {ECO:0007829|PeptideAtlas:A0A3Q2I9S7};
KW Reference proteome {ECO:0000313|Proteomes:UP000002281}.
FT DOMAIN 34..127
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 154..253
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 262..360
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
SQ SEQUENCE 453 AA; 49908 MW; DC38DA8F30FE1D1A CRC64;
MVTIVGVAIP TCDYFGYWGQ GTLVTVSSAS TTAPKVFALA PGCGTTSDST VALGCLVSGY
FPEPVKVSWN SGSLTSGVHT FPSVLQSSGF YSLSSMVTVP ASTWTSETYI CNVVHAASNF
KVDKRIEPIP NNHQKVCDMS KCPKCPAPEL LGGPSVFIFP PNPKDTLMIT RTPEVTCVVV
DVSQENPDVK FNWYMDGVEV RTATTRPKEE QFNSTYRVVS VLRIQHQDWL SGKEFKCKVN
NQALPQPIER TITKTKGRSQ EPQVYVLAPH PDELSKSKVS VTCLVKDFYP PEINIEWQSN
GQPELETKYS TTQAQQDSDG SYFLYSKLSV DRNRWQQGTT FTCGVMHEAV ENHYTQKNVS
HSPELALDES CAETQDGELD GLWTTISIFI TLFLLSVCYS ATVTLFKVGQ AVPTSSIRCH
HAVPQCPHHV FTLSHTVPTS SPCCLITLPK LSH
//
