ID A0A3Q2IA98_HORSE Unreviewed; 907 AA.
AC A0A3Q2IA98;
DT 10-APR-2019, integrated into UniProtKB/TrEMBL.
DT 13-SEP-2023, sequence version 2.
DT 27-MAR-2024, entry version 23.
DE SubName: Full=Adhesion G protein-coupled receptor F1 {ECO:0000313|Ensembl:ENSECAP00000042751.2};
GN Name=ADGRF1 {ECO:0000313|VGNC:VGNC:15103};
OS Equus caballus (Horse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Perissodactyla; Equidae; Equus.
OX NCBI_TaxID=9796 {ECO:0000313|Ensembl:ENSECAP00000042751.2, ECO:0000313|Proteomes:UP000002281};
RN [1] {ECO:0000313|Ensembl:ENSECAP00000042751.2, ECO:0000313|Proteomes:UP000002281}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Thoroughbred {ECO:0000313|Ensembl:ENSECAP00000042751.2,
RC ECO:0000313|Proteomes:UP000002281};
RX PubMed=19892987; DOI=10.1126/science.1178158;
RG Broad Institute Genome Sequencing Platform;
RG Broad Institute Whole Genome Assembly Team;
RA Wade C.M., Giulotto E., Sigurdsson S., Zoli M., Gnerre S., Imsland F.,
RA Lear T.L., Adelson D.L., Bailey E., Bellone R.R., Bloecker H., Distl O.,
RA Edgar R.C., Garber M., Leeb T., Mauceli E., MacLeod J.N., Penedo M.C.T.,
RA Raison J.M., Sharpe T., Vogel J., Andersson L., Antczak D.F., Biagi T.,
RA Binns M.M., Chowdhary B.P., Coleman S.J., Della Valle G., Fryc S.,
RA Guerin G., Hasegawa T., Hill E.W., Jurka J., Kiialainen A., Lindgren G.,
RA Liu J., Magnani E., Mickelson J.R., Murray J., Nergadze S.G., Onofrio R.,
RA Pedroni S., Piras M.F., Raudsepp T., Rocchi M., Roeed K.H., Ryder O.A.,
RA Searle S., Skow L., Swinburne J.E., Syvaenen A.C., Tozaki T., Valberg S.J.,
RA Vaudin M., White J.R., Zody M.C., Lander E.S., Lindblad-Toh K.;
RT "Genome sequence, comparative analysis, and population genetics of the
RT domestic horse.";
RL Science 326:865-867(2009).
RN [2] {ECO:0000313|Ensembl:ENSECAP00000042751.2}
RP IDENTIFICATION.
RC STRAIN=Thoroughbred {ECO:0000313|Ensembl:ENSECAP00000042751.2};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004651};
CC Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 2 family.
CC Adhesion G-protein coupled receptor (ADGR) subfamily.
CC {ECO:0000256|ARBA:ARBA00007343}.
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DR AlphaFoldDB; A0A3Q2IA98; -.
DR Ensembl; ENSECAT00000064372.2; ENSECAP00000042751.2; ENSECAG00000011113.3.
DR VGNC; VGNC:15103; ADGRF1.
DR GeneTree; ENSGT00940000161228; -.
DR OrthoDB; 3876300at2759; -.
DR Proteomes; UP000002281; Chromosome 20.
DR Bgee; ENSECAG00000011113; Expressed in adult mammalian kidney and 6 other cell types or tissues.
DR ExpressionAtlas; A0A3Q2IA98; baseline.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0004930; F:G protein-coupled receptor activity; IEA:InterPro.
DR GO; GO:0007166; P:cell surface receptor signaling pathway; IEA:InterPro.
DR Gene3D; 1.25.40.610; -; 1.
DR Gene3D; 2.60.220.50; -; 1.
DR Gene3D; 1.20.1070.10; Rhodopsin 7-helix transmembrane proteins; 1.
DR InterPro; IPR046338; GAIN_dom_sf.
DR InterPro; IPR017981; GPCR_2-like_7TM.
DR InterPro; IPR008078; GPCR_2_Ig-hepta-like_rcpt.
DR InterPro; IPR000832; GPCR_2_secretin-like.
DR InterPro; IPR000203; GPS.
DR InterPro; IPR000082; SEA_dom.
DR PANTHER; PTHR45813:SF3; ADHESION G-PROTEIN COUPLED RECEPTOR F1; 1.
DR PANTHER; PTHR45813; EF-HAND DOMAIN-CONTAINING PROTEIN; 1.
DR Pfam; PF00002; 7tm_2; 1.
DR Pfam; PF01825; GPS; 1.
DR Pfam; PF01390; SEA; 1.
DR PRINTS; PR00249; GPCRSECRETIN.
DR PRINTS; PR01695; IGHEPTARCPTR.
DR SMART; SM00303; GPS; 1.
DR PROSITE; PS50261; G_PROTEIN_RECEP_F2_4; 1.
DR PROSITE; PS50221; GPS; 1.
DR PROSITE; PS50024; SEA; 1.
PE 3: Inferred from homology;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000002281};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 604..628
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 640..664
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 684..704
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 716..737
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 761..784
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 810..829
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 835..858
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 165..273
FT /note="SEA"
FT /evidence="ECO:0000259|PROSITE:PS50024"
FT DOMAIN 602..859
FT /note="G-protein coupled receptors family 2 profile 2"
FT /evidence="ECO:0000259|PROSITE:PS50261"
FT REGION 885..907
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 907 AA; 101064 MW; 6F331FC5F79589C4 CRC64;
MRGEESAVQE KERDLLNMRV RVFWLVSIFA IAESRGGFLE RRDGIKTKRE LTVNEKKPQG
AVQEYELLLQ VAYGDSKEKR DLKSFLKLLN PPSLWSNGPM TIIRAKATTY CYNKNGFLRC
ACEDDYTWFP PSCLDPQKCY LHTAGSYQSC DCHLNNLTQS INFCERTKVW GTFKINETFT
KDLLNSSSAT HSRYTAGIEL QLKEAYKRIP GFESVRVTQF RDGSILAGYE VVGSSSTAEL
LSAIEQVAEE AKAGLHQLFP LEDDSFRVFG KVQCNSIGFG FGSTNDEYTL PCSSGYTGSI
TARCQPSGWQ VLRETCVLSQ LEELKKNFSV IADNATEAAV SSVVRSLSVV IQQSQSTTAG
NLASVVSILG NVSSLSTARH FRVSNSTMED IIRIADHILN SSSVTNWTVL LREEKHASSQ
LLETLENISM LVPPTALPLN FSREFINWKG IPGSEIQLEK GYNYQTEMLP QNISIPIRGH
VLIGSDQFQR SLPETVISMA SLTMGNILPI TQNGNAQVNG PVISTVIQNY TINEIFLIFS
KIESNLSQPR CVFWDFSHLR WNNAGCHLVN ETPDTVMCRC THLTSFSMLM ASFVPPAIIP
VVKWITFVGL GISIGSLILC LIIEALFWKQ VKKSQTSHTR HICMVNIALC LLIADVWFIV
AATVDTTVNP SGVCIAAVFF THLFYLSLFF WMLMLGILLA YRIIFVFHHM AMPSMMAVGF
CLGYGCPLII SVITIAVTQP SDSYKSKDVC WLNWAEGSKP LLAFGVPALT IVAVNLVVVL
LVLTKLWRPA VGERLSQDYK ATIVRMGKSL LILTPLLGLT WGFGIGIMVD RQNPAWHVIF
ASLNAFQGFF ILCFGILLDG KLRQLLFNKL SPLSSWKHAS KQKSSDLSAQ HKFAKPFNPL
QHKGKLQ
//
