ID A0A3Q2IAE8_HORSE Unreviewed; 1938 AA.
AC A0A3Q2IAE8;
DT 10-APR-2019, integrated into UniProtKB/TrEMBL.
DT 13-SEP-2023, sequence version 3.
DT 27-MAR-2024, entry version 23.
DE SubName: Full=DS cell adhesion molecule like 1 {ECO:0000313|Ensembl:ENSECAP00000044499.3};
GN Name=DSCAML1 {ECO:0000313|Ensembl:ENSECAP00000044499.3,
GN ECO:0000313|VGNC:VGNC:59156};
OS Equus caballus (Horse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Perissodactyla; Equidae; Equus.
OX NCBI_TaxID=9796 {ECO:0000313|Ensembl:ENSECAP00000044499.3, ECO:0000313|Proteomes:UP000002281};
RN [1] {ECO:0000313|Ensembl:ENSECAP00000044499.3, ECO:0000313|Proteomes:UP000002281}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Thoroughbred {ECO:0000313|Ensembl:ENSECAP00000044499.3,
RC ECO:0000313|Proteomes:UP000002281};
RX PubMed=19892987; DOI=10.1126/science.1178158;
RG Broad Institute Genome Sequencing Platform;
RG Broad Institute Whole Genome Assembly Team;
RA Wade C.M., Giulotto E., Sigurdsson S., Zoli M., Gnerre S., Imsland F.,
RA Lear T.L., Adelson D.L., Bailey E., Bellone R.R., Bloecker H., Distl O.,
RA Edgar R.C., Garber M., Leeb T., Mauceli E., MacLeod J.N., Penedo M.C.T.,
RA Raison J.M., Sharpe T., Vogel J., Andersson L., Antczak D.F., Biagi T.,
RA Binns M.M., Chowdhary B.P., Coleman S.J., Della Valle G., Fryc S.,
RA Guerin G., Hasegawa T., Hill E.W., Jurka J., Kiialainen A., Lindgren G.,
RA Liu J., Magnani E., Mickelson J.R., Murray J., Nergadze S.G., Onofrio R.,
RA Pedroni S., Piras M.F., Raudsepp T., Rocchi M., Roeed K.H., Ryder O.A.,
RA Searle S., Skow L., Swinburne J.E., Syvaenen A.C., Tozaki T., Valberg S.J.,
RA Vaudin M., White J.R., Zody M.C., Lander E.S., Lindblad-Toh K.;
RT "Genome sequence, comparative analysis, and population genetics of the
RT domestic horse.";
RL Science 326:865-867(2009).
RN [2] {ECO:0000313|Ensembl:ENSECAP00000044499.3}
RP IDENTIFICATION.
RC STRAIN=Thoroughbred {ECO:0000313|Ensembl:ENSECAP00000044499.3};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Synapse {ECO:0000256|ARBA:ARBA00034103}.
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DR STRING; 9796.ENSECAP00000044499; -.
DR PaxDb; 9796-ENSECAP00000044499; -.
DR Ensembl; ENSECAT00000064959.3; ENSECAP00000044499.3; ENSECAG00000009829.4.
DR VGNC; VGNC:59156; DSCAML1.
DR GeneTree; ENSGT00940000155354; -.
DR InParanoid; A0A3Q2IAE8; -.
DR OMA; GHTMELP; -.
DR Proteomes; UP000002281; Chromosome 7.
DR Bgee; ENSECAG00000009829; Expressed in retina and 8 other cell types or tissues.
DR GO; GO:0030424; C:axon; IBA:GO_Central.
DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR GO; GO:0045202; C:synapse; IEA:UniProtKB-SubCell.
DR GO; GO:0098632; F:cell-cell adhesion mediator activity; IBA:GO_Central.
DR GO; GO:0007411; P:axon guidance; IBA:GO_Central.
DR GO; GO:0070593; P:dendrite self-avoidance; IBA:GO_Central.
DR GO; GO:0007156; P:homophilic cell adhesion via plasma membrane adhesion molecules; IBA:GO_Central.
DR CDD; cd00063; FN3; 6.
DR CDD; cd00096; Ig; 1.
DR CDD; cd05734; Ig_DSCAM; 1.
DR CDD; cd05735; Ig_DSCAM; 1.
DR Gene3D; 2.60.40.10; Immunoglobulins; 15.
DR InterPro; IPR003961; FN3_dom.
DR InterPro; IPR036116; FN3_sf.
DR InterPro; IPR007110; Ig-like_dom.
DR InterPro; IPR036179; Ig-like_dom_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR013098; Ig_I-set.
DR InterPro; IPR003599; Ig_sub.
DR InterPro; IPR003598; Ig_sub2.
DR InterPro; IPR013106; Ig_V-set.
DR PANTHER; PTHR10075; BASIGIN RELATED; 1.
DR PANTHER; PTHR10075:SF72; DOWN SYNDROME CELL ADHESION MOLECULE-LIKE PROTEIN 1; 1.
DR Pfam; PF00041; fn3; 5.
DR Pfam; PF07679; I-set; 4.
DR Pfam; PF13927; Ig_3; 4.
DR SMART; SM00060; FN3; 6.
DR SMART; SM00409; IG; 9.
DR SMART; SM00408; IGc2; 8.
DR SMART; SM00406; IGv; 2.
DR SUPFAM; SSF49265; Fibronectin type III; 3.
DR SUPFAM; SSF48726; Immunoglobulin; 9.
DR PROSITE; PS50853; FN3; 6.
DR PROSITE; PS50835; IG_LIKE; 9.
PE 4: Predicted;
KW Immunoglobulin domain {ECO:0000256|ARBA:ARBA00023319};
KW Neurogenesis {ECO:0000256|ARBA:ARBA00022902};
KW Reference proteome {ECO:0000313|Proteomes:UP000002281};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Synapse {ECO:0000256|ARBA:ARBA00023018}.
FT DOMAIN 1..81
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 90..174
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 178..260
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 272..365
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 370..450
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 460..549
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 554..648
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 652..749
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 751..848
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 853..952
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 957..1053
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 1057..1152
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 1142..1241
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 1247..1341
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 1342..1442
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT REGION 1487..1540
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1600..1626
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1658..1688
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1725..1748
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1832..1938
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1507..1530
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1611..1626
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1864..1896
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1910..1938
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1938 AA; 211454 MW; ABFF740EA8A155F4 CRC64;
MRGNVAVFKC LIPSSVQEYV SVVSWEKDTV SIIPENRFFI TSHGGLYISD VQKEDALSTY
RCITKHKYSG ETRQSNGARL SVTDPAESIP TILDGFHSQE VWAGHTVELP CTASGYPIPA
IRWLKDGRPL PADSRWTKHI TGLTISDLRT EDSGTYICEV TNTFGSAEAT GTLTVIDPLH
VTLTPKKLKT GIGSTVILSC ALMGSTEFTI RWYRNTELVL PDEAISIRGL SNETLLITSA
QKSHSGAYQC FATRKAQTAQ DFAIIVLEDG TPRIVSSFSE KVVNPGEQFS LMCAAKGAPP
PTVTWALDDE PILRDGSHRT NQYTMSDGTT ISHMNVTGPQ IRDGGVYRCT ARNSVGSAEY
QARINVRGPP SIRAMRNITA VAGRDTLINC RVIGYPYYSI KWYKDALLLP DNHRQVVFEN
GTLKLTDVQK GMDEGEYLCS VLIQPQLSIS QSVHVAVKVP PLIQPFEFPP ASIGQLLYIP
CVVSSGDMPI RITWRKDGQV IISGSGVTIE SKEFMSSLQI SSVSLKHNGN YTCIASNAAA
TVSRERQLIV RVPPRFVVQP NNQDGIYGKA GVLNCSVDGY PPPKVMWKHA KGSGNPQQYH
PVPLTGRIQI LPNSSLLIRH VLEEDIGYYL CQASNGVGTD ISKSMFLTVK IPAMITSHPN
TTIAIKGHAK ELNCTARGER PIIIRWEKGD TVIDPDRVMR YAITTKDNGD EVVSTLKLKP
ADRGDSVFFS CHAINSYGED RGLIQLTVQE PPDPPELEIR EVKARSMNLR WTQRFDGNSI
ITGFDIEYKN KSDSWDFKQS TRNISPTINQ ANIVDLHPAS VYSIRMYSFN KIGRSEPSKE
LTISTEEAAP DGPPMDVTLQ PVTSQSIQVT WKAPKKELQN GVIRGYQIGY RENSPGSNGQ
YSIVEMKATG DSEVYTLDNL KKFAQYGVVV QAFNRAGTGP SSSEINATTL EDVPSQPPEN
VRALSITSDV AVISWSEPPR STLNGVLKGY RVIFWSLYVD GEWGEMQNIT TTRERVELRG
MEKFTNYSVQ VLAYTQAGDG VRSSVLYIQT KEDVPGPPAG IKAVPSSASS VVVSWLPPTK
PNGVIRKYTI FCSSPGSGQP APSEYETSPE QLFYRIAHLN RGQQYLLWVA AVTSAGRGNS
SEKVTIEPAG KAPAKIISFG GTVTTPWMKD VRLPCNSVGD PAPAVKWTKD SEDSAIPVSM
DGHRLIHTNG TLLLRAVKAE DSGYYTCTAT NTGGFDTIIV NLLVQVPPDQ PRLTVSKTSA
SSITLTWIPG DNGGSSIRGF VLQYSVDNSE EWKDVFISSS ERSFKLDSLK CGTWYKVKLA
AKNSVGSGRI SEIIEAKTHG REPSFSKDQH LFTHINSTHA RLNLQGWNNG GCPITAIVLE
YRPKGTWAWQ GLRANSSGEV FLTELREATW YELRMRACNS AGCGNETAQF ATLDYDGSTI
PPIKSAQGEG DDVKKLFTIG CPVILATLGV ALLFIVRKKR KEKRLKRLRE NRLLRPHCPE
KNPPPTSMAA ESPTSSPSPH SKNNRSFDTP VKGPPQGPRL HIDIPRVQLL IEDKEGIKQL
GDDKATIPVT DAEFSQAVNP QSFCTGVSLH HPALIQSSGP LIDMSDIRPG TNPVSRKNVK
SAHSTRNRYS SQWTLTKCQA STPARTLTSD WRTVGSQHGV TVTESDSYSA SLSQDTDKGR
NSMVSTESAS STYEELARAY EHAKLEEQLQ HAKFEITECF ISDSSSDQMT TGTNENADSM
TSMSTPSEPG ICRFTSSPPK PQDADRGKNV AVPIPHRANK SDYCNLPLYA KSEAFFRKAD
GREPCPVVPP REASIRNLAR TYHTQARHLT LDPASKPLGL PHPGAPAAAS TATLPQRTLA
MPAPPAGTAP PAPGPTPAEP PAAPSAAPPA PSTEPPRAGG PHTKMGGSRD SLLEMSTSGV
GRSQKQGAGA YSKSYTLV
//
