ID A0A3Q2IAJ0_HORSE Unreviewed; 940 AA.
AC A0A3Q2IAJ0;
DT 10-APR-2019, integrated into UniProtKB/TrEMBL.
DT 13-SEP-2023, sequence version 2.
DT 27-MAR-2024, entry version 20.
DE SubName: Full=RAB44, member RAS onco family {ECO:0000313|Ensembl:ENSECAP00000045261.2};
GN Name=RAB44 {ECO:0000313|Ensembl:ENSECAP00000045261.2,
GN ECO:0000313|VGNC:VGNC:51999};
OS Equus caballus (Horse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Perissodactyla; Equidae; Equus.
OX NCBI_TaxID=9796 {ECO:0000313|Ensembl:ENSECAP00000045261.2, ECO:0000313|Proteomes:UP000002281};
RN [1] {ECO:0000313|Ensembl:ENSECAP00000045261.2, ECO:0000313|Proteomes:UP000002281}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Thoroughbred {ECO:0000313|Ensembl:ENSECAP00000045261.2,
RC ECO:0000313|Proteomes:UP000002281};
RX PubMed=19892987; DOI=10.1126/science.1178158;
RG Broad Institute Genome Sequencing Platform;
RG Broad Institute Whole Genome Assembly Team;
RA Wade C.M., Giulotto E., Sigurdsson S., Zoli M., Gnerre S., Imsland F.,
RA Lear T.L., Adelson D.L., Bailey E., Bellone R.R., Bloecker H., Distl O.,
RA Edgar R.C., Garber M., Leeb T., Mauceli E., MacLeod J.N., Penedo M.C.T.,
RA Raison J.M., Sharpe T., Vogel J., Andersson L., Antczak D.F., Biagi T.,
RA Binns M.M., Chowdhary B.P., Coleman S.J., Della Valle G., Fryc S.,
RA Guerin G., Hasegawa T., Hill E.W., Jurka J., Kiialainen A., Lindgren G.,
RA Liu J., Magnani E., Mickelson J.R., Murray J., Nergadze S.G., Onofrio R.,
RA Pedroni S., Piras M.F., Raudsepp T., Rocchi M., Roeed K.H., Ryder O.A.,
RA Searle S., Skow L., Swinburne J.E., Syvaenen A.C., Tozaki T., Valberg S.J.,
RA Vaudin M., White J.R., Zody M.C., Lander E.S., Lindblad-Toh K.;
RT "Genome sequence, comparative analysis, and population genetics of the
RT domestic horse.";
RL Science 326:865-867(2009).
RN [2] {ECO:0000313|Ensembl:ENSECAP00000045261.2}
RP IDENTIFICATION.
RC STRAIN=Thoroughbred {ECO:0000313|Ensembl:ENSECAP00000045261.2};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR AlphaFoldDB; A0A3Q2IAJ0; -.
DR STRING; 9796.ENSECAP00000045261; -.
DR PaxDb; 9796-ENSECAP00000045261; -.
DR Ensembl; ENSECAT00000055356.3; ENSECAP00000045261.2; ENSECAG00000000519.4.
DR VGNC; VGNC:51999; RAB44.
DR GeneTree; ENSGT00940000160379; -.
DR InParanoid; A0A3Q2IAJ0; -.
DR OMA; SEMIFDW; -.
DR Proteomes; UP000002281; Chromosome 20.
DR Bgee; ENSECAG00000000519; Expressed in bone marrow and 11 other cell types or tissues.
DR GO; GO:0005525; F:GTP binding; IEA:InterPro.
DR GO; GO:0003924; F:GTPase activity; IEA:InterPro.
DR GO; GO:0016192; P:vesicle-mediated transport; IBA:GO_Central.
DR CDD; cd00154; Rab; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR InterPro; IPR011992; EF-hand-dom_pair.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR005225; Small_GTP-bd_dom.
DR InterPro; IPR001806; Small_GTPase.
DR NCBIfam; TIGR00231; small_GTP; 1.
DR PANTHER; PTHR47977; RAS-RELATED PROTEIN RAB; 1.
DR PANTHER; PTHR47977:SF72; RAS-RELATED PROTEIN RAB-44; 1.
DR Pfam; PF00071; Ras; 1.
DR PRINTS; PR00449; RASTRNSFRMNG.
DR SMART; SM00175; RAB; 1.
DR SMART; SM00173; RAS; 1.
DR SMART; SM00174; RHO; 1.
DR SUPFAM; SSF47473; EF-hand; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS51419; RAB; 1.
PE 4: Predicted;
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000002281}.
FT REGION 1..39
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 112..138
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 279..300
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 315..493
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 506..719
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 736..778
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 315..331
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 372..393
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 404..420
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 510..525
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 597..613
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 636..651
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 673..705
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 741..761
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 940 AA; 102383 MW; D03FB6360A475F71 CRC64;
MESERVPRKG RKLGSSRRRQ IRELADGQDA PVAPETESWS SQAAAELQGF FKDCGAKERG
FVTREDLAVA KFSFLGSEEE PGMIFDWVDV ERKGRLSLEE FSSGLQNIFG SSPRTHRLRR
RRPLTSQQRS LASSLPALEE ADPEEKAAFF AFMQQLGAGH LLPEQAEIWQ LWGKLRQEEP
QLAGNLEGFL AKMSSRLQEA RADKEALELS LRKRDSDHHR EVQQLYEEME QQIRREKQQL
QAESDSRDLA LSSQMQEALE AKEREVQRLT EDQRELEAQL RHLSSSHQAA SSENQQLREA
ERDLAGQLEE VRGQLQVTQG RLNTARSRVS WQMEEDPSGP KAGEEKPPDP QAVSSEGSPL
PGLFGDNDDW DQLLGSFSSP PQKYLQLSWS PPLTPRSPAG PQTPRGVRQI SISEPQALLF
GQEPSSDPDG APRSPPGVPS RAKEGEGGDP DGQDISPEQP VQPHSLEPKE ESGPGPEDHF
LWGLPGTPTG ESGAVVAAAL KVLIPLEDGP PPRVNSPPPS PPAGPSEQFH ASFLDDRGPG
PGPVPATPPR QREVLCQDPY TTGSGPELGS PGAEALTPGL PEPSQGLEPA GEAPAEELEQ
GELRPDAQEG CPRGLREAHG QVLAADGLPA LRHQSLEEGP RAEERKEADG GGQAGSSEQP
AEAHGLKPGR SELPQQDPPP APLPYATPQA QAPGRPSPPR GSPPRGAQPG DAAGPQEPTK
TLPTAEELEV PPTIVHAEGE QGPSQRREPR AQSRLEDPGM DSREAGLTPS PGDPVASEPL
ANPDYIFHVV FLGDSNVGKT SFLYLLHHNS FATGLTATVG VDFRVKNLLV DGKCFALQFW
DTAGQERYHS VTRQLLRKAD GVVLMYDVTS QESFAHIRYW LDCLQELGVS FGECSAALGH
NILEPMVNLA RSLKMQEDRL MGSLVKVAPE RPPKRAFCCF
//
