ID A0A3Q2IAS2_HORSE Unreviewed; 544 AA.
AC A0A3Q2IAS2;
DT 10-APR-2019, integrated into UniProtKB/TrEMBL.
DT 13-SEP-2023, sequence version 2.
DT 27-MAR-2024, entry version 27.
DE SubName: Full=Single Ig and TIR domain containing {ECO:0000313|Ensembl:ENSECAP00000045361.2};
GN Name=SIGIRR {ECO:0000313|VGNC:VGNC:58242};
OS Equus caballus (Horse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Perissodactyla; Equidae; Equus.
OX NCBI_TaxID=9796 {ECO:0000313|Ensembl:ENSECAP00000045361.2, ECO:0000313|Proteomes:UP000002281};
RN [1] {ECO:0000313|Ensembl:ENSECAP00000045361.2, ECO:0000313|Proteomes:UP000002281}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Thoroughbred {ECO:0000313|Ensembl:ENSECAP00000045361.2,
RC ECO:0000313|Proteomes:UP000002281};
RX PubMed=19892987; DOI=10.1126/science.1178158;
RG Broad Institute Genome Sequencing Platform;
RG Broad Institute Whole Genome Assembly Team;
RA Wade C.M., Giulotto E., Sigurdsson S., Zoli M., Gnerre S., Imsland F.,
RA Lear T.L., Adelson D.L., Bailey E., Bellone R.R., Bloecker H., Distl O.,
RA Edgar R.C., Garber M., Leeb T., Mauceli E., MacLeod J.N., Penedo M.C.T.,
RA Raison J.M., Sharpe T., Vogel J., Andersson L., Antczak D.F., Biagi T.,
RA Binns M.M., Chowdhary B.P., Coleman S.J., Della Valle G., Fryc S.,
RA Guerin G., Hasegawa T., Hill E.W., Jurka J., Kiialainen A., Lindgren G.,
RA Liu J., Magnani E., Mickelson J.R., Murray J., Nergadze S.G., Onofrio R.,
RA Pedroni S., Piras M.F., Raudsepp T., Rocchi M., Roeed K.H., Ryder O.A.,
RA Searle S., Skow L., Swinburne J.E., Syvaenen A.C., Tozaki T., Valberg S.J.,
RA Vaudin M., White J.R., Zody M.C., Lander E.S., Lindblad-Toh K.;
RT "Genome sequence, comparative analysis, and population genetics of the
RT domestic horse.";
RL Science 326:865-867(2009).
RN [2] {ECO:0000313|Ensembl:ENSECAP00000045361.2}
RP IDENTIFICATION.
RC STRAIN=Thoroughbred {ECO:0000313|Ensembl:ENSECAP00000045361.2};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the interleukin-1 receptor family.
CC {ECO:0000256|ARBA:ARBA00009752}.
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DR AlphaFoldDB; A0A3Q2IAS2; -.
DR Ensembl; ENSECAT00000064185.2; ENSECAP00000045361.2; ENSECAG00000022225.4.
DR VGNC; VGNC:58242; SIGIRR.
DR GeneTree; ENSGT01090000259985; -.
DR OrthoDB; 5349166at2759; -.
DR Proteomes; UP000002281; Chromosome 12.
DR Bgee; ENSECAG00000022225; Expressed in leukocyte and 21 other cell types or tissues.
DR ExpressionAtlas; A0A3Q2IAS2; baseline.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0006953; P:acute-phase response; IEA:Ensembl.
DR GO; GO:0032682; P:negative regulation of chemokine production; IEA:Ensembl.
DR GO; GO:0001960; P:negative regulation of cytokine-mediated signaling pathway; IEA:Ensembl.
DR GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR CDD; cd00096; Ig; 1.
DR Gene3D; 2.60.40.10; Immunoglobulins; 1.
DR Gene3D; 3.40.50.10140; Toll/interleukin-1 receptor homology (TIR) domain; 1.
DR InterPro; IPR007110; Ig-like_dom.
DR InterPro; IPR036179; Ig-like_dom_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR015621; IL-1_rcpt_fam.
DR InterPro; IPR000157; TIR_dom.
DR InterPro; IPR035897; Toll_tir_struct_dom_sf.
DR PANTHER; PTHR11890; INTERLEUKIN-1 RECEPTOR FAMILY MEMBER; 1.
DR PANTHER; PTHR11890:SF19; SINGLE IG IL-1-RELATED RECEPTOR; 1.
DR Pfam; PF01582; TIR; 1.
DR PRINTS; PR01537; INTRLKN1R1F.
DR SMART; SM00255; TIR; 1.
DR SUPFAM; SSF48726; Immunoglobulin; 1.
DR SUPFAM; SSF52200; Toll/Interleukin receptor TIR domain; 1.
DR PROSITE; PS50835; IG_LIKE; 1.
DR PROSITE; PS50104; TIR; 1.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000002281};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 253..274
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 143..243
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 297..441
FT /note="TIR"
FT /evidence="ECO:0000259|PROSITE:PS50104"
FT REGION 473..515
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 473..488
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 544 AA; 60362 MW; E3DC483054DAF28F CRC64;
MTSVTDIPPR RKKPEPGDFV PSHSAPLLHV CLHPHPLTPF PPEACPRSLA WRRGGPQHVW
DVCAHMCVPV RVRGDGRLCV RHWRPRQPAT HPGTLTDWSQ GQRVSPAQPL GYRLARPSCP
VEPGVAPRGG PGQTMAGVCD RAPDFLSPSG NQVLWPALGS VVTLNCTAWV VSGPHCPLPS
VQWLKDGLVL GNESHYDLHE DSWIKSNLSE VLASSVLGIN LTSTDDYGAF TCSIQNASSS
SFTLRRAGSA GHVAAVLASL LVLLALLLAA LLYVKCRLNV LLWYQDAYGE VEMNDGKLYD
AYVSYSDSPE DRKFVNFILK PQLERRRGYK LFLDDRDLLP HAEPSADLLV NLSRCRRLVV
VLSDAFLRRA WCSHSFREGL CRLLELTRRP IFITFEGPRR DPAHPALRLL RQHRHLVTLL
LWRPGSVTPS SDFWKELQLA LPRKVQYRTT EGDPQTRLQD DKDPMLIVRG RVPEGRTLDP
DLDPDPEGDL GVRGPIFGEP SAPPQASGVS LGEARGSEVD ISDLGSRNYS ARTDFYCLVS
EDDV
//
