ID A0A3Q2IAX3_HORSE Unreviewed; 1396 AA.
AC A0A3Q2IAX3;
DT 10-APR-2019, integrated into UniProtKB/TrEMBL.
DT 13-SEP-2023, sequence version 2.
DT 27-MAR-2024, entry version 22.
DE SubName: Full=Pleckstrin homology and RhoGEF domain containing G3 {ECO:0000313|Ensembl:ENSECAP00000045230.2};
GN Name=PLEKHG3 {ECO:0000313|Ensembl:ENSECAP00000045230.2,
GN ECO:0000313|VGNC:VGNC:21568};
OS Equus caballus (Horse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Perissodactyla; Equidae; Equus.
OX NCBI_TaxID=9796 {ECO:0000313|Ensembl:ENSECAP00000045230.2, ECO:0000313|Proteomes:UP000002281};
RN [1] {ECO:0000313|Ensembl:ENSECAP00000045230.2, ECO:0000313|Proteomes:UP000002281}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Thoroughbred {ECO:0000313|Ensembl:ENSECAP00000045230.2,
RC ECO:0000313|Proteomes:UP000002281};
RX PubMed=19892987; DOI=10.1126/science.1178158;
RG Broad Institute Genome Sequencing Platform;
RG Broad Institute Whole Genome Assembly Team;
RA Wade C.M., Giulotto E., Sigurdsson S., Zoli M., Gnerre S., Imsland F.,
RA Lear T.L., Adelson D.L., Bailey E., Bellone R.R., Bloecker H., Distl O.,
RA Edgar R.C., Garber M., Leeb T., Mauceli E., MacLeod J.N., Penedo M.C.T.,
RA Raison J.M., Sharpe T., Vogel J., Andersson L., Antczak D.F., Biagi T.,
RA Binns M.M., Chowdhary B.P., Coleman S.J., Della Valle G., Fryc S.,
RA Guerin G., Hasegawa T., Hill E.W., Jurka J., Kiialainen A., Lindgren G.,
RA Liu J., Magnani E., Mickelson J.R., Murray J., Nergadze S.G., Onofrio R.,
RA Pedroni S., Piras M.F., Raudsepp T., Rocchi M., Roeed K.H., Ryder O.A.,
RA Searle S., Skow L., Swinburne J.E., Syvaenen A.C., Tozaki T., Valberg S.J.,
RA Vaudin M., White J.R., Zody M.C., Lander E.S., Lindblad-Toh K.;
RT "Genome sequence, comparative analysis, and population genetics of the
RT domestic horse.";
RL Science 326:865-867(2009).
RN [2] {ECO:0000313|Ensembl:ENSECAP00000045230.2}
RP IDENTIFICATION.
RC STRAIN=Thoroughbred {ECO:0000313|Ensembl:ENSECAP00000045230.2};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR STRING; 9796.ENSECAP00000045230; -.
DR PaxDb; 9796-ENSECAP00000045230; -.
DR Ensembl; ENSECAT00000043605.2; ENSECAP00000045230.2; ENSECAG00000006117.4.
DR VGNC; VGNC:21568; PLEKHG3.
DR GeneTree; ENSGT00940000156521; -.
DR InParanoid; A0A3Q2IAX3; -.
DR OMA; IVKMWER; -.
DR Proteomes; UP000002281; Chromosome 24.
DR Bgee; ENSECAG00000006117; Expressed in leukocyte and 23 other cell types or tissues.
DR GO; GO:0003779; F:actin binding; IEA:Ensembl.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IBA:GO_Central.
DR GO; GO:0031267; F:small GTPase binding; IBA:GO_Central.
DR GO; GO:0030334; P:regulation of cell migration; IEA:Ensembl.
DR GO; GO:2000114; P:regulation of establishment of cell polarity; IBA:GO_Central.
DR CDD; cd13243; PH_PLEKHG1_G2_G3; 1.
DR CDD; cd00160; RhoGEF; 1.
DR Gene3D; 1.20.900.10; Dbl homology (DH) domain; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR InterPro; IPR035899; DBL_dom_sf.
DR InterPro; IPR000219; DH-domain.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR001849; PH_domain.
DR InterPro; IPR043324; PH_PLEKHG1_G2_G3.
DR PANTHER; PTHR45924; FI17866P1; 1.
DR PANTHER; PTHR45924:SF4; PLECKSTRIN HOMOLOGY DOMAIN-CONTAINING FAMILY G MEMBER 3; 1.
DR Pfam; PF00169; PH; 1.
DR Pfam; PF00621; RhoGEF; 1.
DR SMART; SM00233; PH; 1.
DR SMART; SM00325; RhoGEF; 1.
DR SUPFAM; SSF48065; DBL homology domain (DH-domain); 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR PROSITE; PS50010; DH_2; 1.
DR PROSITE; PS50003; PH_DOMAIN; 1.
PE 4: Predicted;
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000002281}.
FT DOMAIN 171..350
FT /note="DH"
FT /evidence="ECO:0000259|PROSITE:PS50010"
FT DOMAIN 374..472
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT REGION 68..152
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 507..623
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 657..726
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 757..778
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 795..888
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 936..956
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1001..1020
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1133..1220
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1237..1285
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1326..1385
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 85..114
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 134..152
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 524..541
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 573..589
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 596..610
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 795..825
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1184..1217
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1360..1374
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1396 AA; 152917 MW; 9DEF40CE1F3A52E8 CRC64;
MVWMLEKVPF HGAIGVQGQA GQDVLRVPAA APSLRTRSRA VIRAEAWLWG KGLASPFTAV
SLEMSQNLTG VPEPGSDARM PVSASLRQDG SQERPVSLSS STSSSGSSRD SRGAMEEPNA
SEAAAENGAG SPRGRHPPNS NNNSSGWLNR RGPLSPFNSR AAAAPAHKLS YLGRVVREIV
ETERMYVQDL RSIVEDYLLK IIDTPGLLKP EQVSALFGNI ENIYALNSQL LRDLDSCNSD
PVAVASCFVE RSQEFDIYTQ YCNNYPNSVA ALTECMRDKQ QAKFFRDRQE LLQHSLPLGS
YLLKPVQRIL KYHLLLQEIA KHFDEEEDGF EVVEDAIDTM TCVAWYINDM KRRHEHAVRL
QEIQSLLINW KGPDLTIYGE LVLEGTFRVH RVRNERTFFL FDKALLITKK RGDHFVYKGH
IPCSSLMLIE STRDSLCFTV THYKHSKQQY SIQAKTVEEK RSWTHHIKRL ILENHHTTIP
QKAKEAILEM DSYYPNRYRH SPERLKKAWS SQDEVSTHMQ QGRRQSEPTR HLLRQLSEKA
RAAGMKHAGS AGTLLDFGQP AHPRGLQPEA EGAAQEEQEE EEEEEQAFQV SLEDLAGHEG
SEKGARPEPP GSEEEEEESL AVAEQVADFA SSLLAALHCW HYRANALLFS RGAMAKGRRE
SEGSKSCRSP SGRSPTRAEK RMSFESASSL PEVEPDPESG TEQEVFATVE GPSTEEMPSD
SESPEVLDAQ LDVHQELLGL DHPGGIVDFV VAESTEDLKA LSSEEEEEEP ESLLPPSVLD
QASVIAERFV SSFSRRSSLA LEDSKSSGFG TPRLTSRSSS VLSLEGSEKG LARGGSTSDP
LGSQLPQEVD TTVGAAMESG PSVNGTQPPS PGCPVEPDKS SCKKKESMLS TRDRLLLDKI
KSYYENAEHH DAGFSIRRRE SLSYIPKGLV RNSVSRFNSL PKPDPEPVAP LGHKRQAGSR
PASWALFDLP GPGEAGAGEP APITDAEFRP SSEIVKIWEG MESSGGSPRK GPGQGQANGF
DLHEPLFILE EHELGAITEE SATASPESVS PTERPSPAHL ARELKELVKE LSNGTQGELV
APLHPRIVQL SHVMDSRVSE RVKNKVYQLA RQYSLRIKSK SVTARPPLQW EKAAATVPRL
QEEAGAPSGG SGRRKPVLSL LNPEQPTTGQ EPSPPKPCSA GETSPRRFSC SPSAASPRTP
SSGVRPSSRS PLSPFNTETF HWPDVRELCS KYASYDESLQ AEGSRPRGPP VYRSRSVPES
IVEPPLPGRA GRCSSLSSQR ARAGLEAAQL QPPGALPPGG PAAEGALYVT ADLTLDNNRR
VIVMEKGPLP QPPVGLEDGG GHGPSLPAAR VGQGQDFQES AEYRPKEEGP RDPADPSQQG
RVRNLREKFQ ALNSVG
//
