ID A0A3Q2IAZ4_HORSE Unreviewed; 2363 AA.
AC A0A3Q2IAZ4;
DT 10-APR-2019, integrated into UniProtKB/TrEMBL.
DT 13-SEP-2023, sequence version 2.
DT 24-JAN-2024, entry version 20.
DE SubName: Full=Tetratricopeptide repeat domain 28 {ECO:0000313|Ensembl:ENSECAP00000045250.2};
GN Name=TTC28 {ECO:0000313|Ensembl:ENSECAP00000045250.2,
GN ECO:0000313|VGNC:VGNC:24621};
OS Equus caballus (Horse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Perissodactyla; Equidae; Equus.
OX NCBI_TaxID=9796 {ECO:0000313|Ensembl:ENSECAP00000045250.2, ECO:0000313|Proteomes:UP000002281};
RN [1] {ECO:0000313|Ensembl:ENSECAP00000045250.2, ECO:0000313|Proteomes:UP000002281}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Thoroughbred {ECO:0000313|Ensembl:ENSECAP00000045250.2,
RC ECO:0000313|Proteomes:UP000002281};
RX PubMed=19892987; DOI=10.1126/science.1178158;
RG Broad Institute Genome Sequencing Platform;
RG Broad Institute Whole Genome Assembly Team;
RA Wade C.M., Giulotto E., Sigurdsson S., Zoli M., Gnerre S., Imsland F.,
RA Lear T.L., Adelson D.L., Bailey E., Bellone R.R., Bloecker H., Distl O.,
RA Edgar R.C., Garber M., Leeb T., Mauceli E., MacLeod J.N., Penedo M.C.T.,
RA Raison J.M., Sharpe T., Vogel J., Andersson L., Antczak D.F., Biagi T.,
RA Binns M.M., Chowdhary B.P., Coleman S.J., Della Valle G., Fryc S.,
RA Guerin G., Hasegawa T., Hill E.W., Jurka J., Kiialainen A., Lindgren G.,
RA Liu J., Magnani E., Mickelson J.R., Murray J., Nergadze S.G., Onofrio R.,
RA Pedroni S., Piras M.F., Raudsepp T., Rocchi M., Roeed K.H., Ryder O.A.,
RA Searle S., Skow L., Swinburne J.E., Syvaenen A.C., Tozaki T., Valberg S.J.,
RA Vaudin M., White J.R., Zody M.C., Lander E.S., Lindblad-Toh K.;
RT "Genome sequence, comparative analysis, and population genetics of the
RT domestic horse.";
RL Science 326:865-867(2009).
RN [2] {ECO:0000313|Ensembl:ENSECAP00000045250.2}
RP IDENTIFICATION.
RC STRAIN=Thoroughbred {ECO:0000313|Ensembl:ENSECAP00000045250.2};
RG Ensembl;
RL Submitted (JUL-2023) to UniProtKB.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR Ensembl; ENSECAT00000048780.2; ENSECAP00000045250.2; ENSECAG00000001164.4.
DR VGNC; VGNC:24621; TTC28.
DR GeneTree; ENSGT00940000156428; -.
DR Proteomes; UP000002281; Chromosome 8.
DR Bgee; ENSECAG00000001164; Expressed in articular cartilage of joint and 24 other cell types or tissues.
DR ExpressionAtlas; A0A3Q2IAZ4; baseline.
DR Gene3D; 1.25.40.10; Tetratricopeptide repeat domain; 5.
DR InterPro; IPR024983; CHAT_dom.
DR InterPro; IPR011990; TPR-like_helical_dom_sf.
DR InterPro; IPR019734; TPR_repeat.
DR PANTHER; PTHR10098; RAPSYN-RELATED; 1.
DR PANTHER; PTHR10098:SF106; TETRATRICOPEPTIDE REPEAT PROTEIN 28; 1.
DR Pfam; PF12770; CHAT; 1.
DR Pfam; PF13424; TPR_12; 9.
DR Pfam; PF13176; TPR_7; 3.
DR SMART; SM00028; TPR; 23.
DR SUPFAM; SSF48452; TPR-like; 6.
DR PROSITE; PS50005; TPR; 12.
DR PROSITE; PS50293; TPR_REGION; 1.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Reference proteome {ECO:0000313|Proteomes:UP000002281};
KW TPR repeat {ECO:0000256|PROSITE-ProRule:PRU00339}.
FT REPEAT 8..41
FT /note="TPR"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00339"
FT REPEAT 196..229
FT /note="TPR"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00339"
FT REPEAT 236..269
FT /note="TPR"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00339"
FT REPEAT 276..309
FT /note="TPR"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00339"
FT REPEAT 396..429
FT /note="TPR"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00339"
FT REPEAT 476..509
FT /note="TPR"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00339"
FT REPEAT 516..549
FT /note="TPR"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00339"
FT REPEAT 636..669
FT /note="TPR"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00339"
FT REPEAT 759..792
FT /note="TPR"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00339"
FT REPEAT 839..872
FT /note="TPR"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00339"
FT REPEAT 879..912
FT /note="TPR"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00339"
FT REPEAT 959..992
FT /note="TPR"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00339"
FT DOMAIN 1273..1595
FT /note="CHAT"
FT /evidence="ECO:0000259|Pfam:PF12770"
FT REGION 1886..1939
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1957..2221
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2329..2349
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 852..879
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 1973..2030
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2063..2110
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2122..2168
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2177..2216
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 2363 AA; 258284 MW; 3060B06182744774 CRC64;
MMKWQPRKKA YFRQGVALQY LGRHADALAA FASGLAQDPK SLQLLVGMVE AAMKSPMRDS
LEPTYQQLQK MKLDKSPFVV VSVVGQELLT AGHHGASVVV LEAALKIGTC SLKLRGSVFS
ALSSAYWSLG NTEKSTGYMQ QDLDVAKTLG DQTGECRAHG NLGSAFFSKG NYREALTNHR
HQLVLAMKLK DREAASSALS SLGHVYTAIG DYPNALASHK QCVLLAKQSK DELSEARELG
NMGAVYIAMG DFENAVQCHE QHLKIAKDLG NKREEARAYS NLGSAYHYRR NFDKAMSYHN
YVLELAQELM EKAIEMRAYA GLGHAARCMQ DLERAKQYHE QQLGIAEDLK DRAAEGRASS
NLGIIHQMKG DYDTALKLHK THLCIAQELS DYAAQGRAYG NMGNAYNALG MYDQAVKYHR
QELQISMEVN DRASQASTHG NLAVAYQALG AHDRALQHYQ NHLNIARELR DIQSEARALS
NLGNFHCSRG EYVQAAPYYE QYLRLAPDLQ DMEGEGKVCH NLGYAHYCLG HYQEAVRYYE
QDLALAKDLH DKLSQAKAYC NLGLAFKALL NFNKAEECQK YLLSLAQSLN NSQAKFRALG
NLGDIFICKK DINGAIKFYE QQLGLAHHVK DRRLEASAYA ALGTAYRMIQ KYDKALGYHT
QELEVYQELS DLPGECRAHG HLAAVYMALG KYTMAFKCYE EQLDLGQKLK DPSLEAQVYG
NMGITKMNMN VMEEAIGYFE QQLAMLQQLS GNESVLDRGR AYGNLGDCYE ALGDYEEAIK
YYEQYLSVAQ SLNRMQDQAK AYRGLGNGHR AMGSLQQALV CFEKRLVVAH ELGEAFNKAQ
AYGELGSLHS QLGNYEQAIS CLERQLNIAR EMKDRALESD AACGLGGVYQ QMGEYDTALQ
YHQLDLQIAE ETNNPTCQGR AYGNLGLTYE SLGTFERAVV YQEQHLSIAA QMNDLVAKTV
SYSSLGRTHH ALQNYSQAVM YLQEGLRLAE QLGRREDEAK IRHGLGLSLW ASGNLEEAQR
QLYRASALFE TIRHEAQLST DYKLSLFDLQ TSSYQALQRV LVSLGHHDEA LAVAERGRTR
AFADLLVERQ TGQQDSDPYS PVTIDQILEM VNGQRGLVLY YSLAAGYLYS WLLAPGAGIL
KFHEHYLGDN TVENSSDFQA GSNATLPTAT SSALEQHVTS VREALGVESY YSRACASSET
ESEAGDIMDQ QFEEMNNKLN SVTDPTGFLR MVRRNNLFNR SCQSMTSLVS NTMSPIKDGT
SSLPRRQSSF ARPPLRALYD LLIAPMEGGL MHSSGPVGRH RQLILVLEGE LYLIPFALLK
GSSSNEYLYE RFALIAVPSL RSLSPQSKSH LRKNPPAYSS STSMAAVIGN PKLPSAVMDR
WLWGPMPSAE EEAYMVSELL GCQPLVGSVA TKERVMSALT QAECVHFATH ISWKLSALVL
TPSVDGNPAS SKSSFGHPYT IPESLRVQDD ASDGESISDC PPLQELLLTA ADVLDLRLPV
KLVVLGSSQE SSSRVTADGV IALTRAFLAA GAQCVLVSLW PVPVAASKMF LHAFYSSLLN
GLKASAALGE AMKVVQSSKA FSNPANWAGF LLIGSDVKLN SPSSLIGQAL TEILQHPERA
RDALRVLLHL VEKSLQRIQN GQRNAMYTSQ QSVENKVGGI PGWQALLTAV GFRLDPPASG
LPAAVFFPTS DPGDRLQQCS STIQSLLGLP NPALQALCKL ITASETGEQL ISRAVKNMVG
MLHQVLVQLQ AGEKEQDFAS APIQVSISVQ LWRLPGCHEF LAALGFDLCE VGQEEVILKT
GKQANRRTMH FALQALLALF DSTELPKRLS LDSSSSLESL ASAQSVSNAL PLGYQHPPFS
PTGADSIASD AISVYSLSSI ASSMSFVSKP EGGSEGGGPR GRQDYDRAKN AYPQRATLPR
SPLSPQTRPA GSKDEEEYEG FSIISTEPLA AYQENRKTRF SPDHKQSRVG TAGGVKVSVS
SKGSISTPNS PVKMTLIPSP NSPFQKVGKL ASSDTGESDQ SSTETDSTVK SQEESNPKLD
PQELAQKILE ETQSHLIAVE RLQRGGSQTS KSSNPEDGIS MPNSAAVFRA SETSAFSRPA
LSHQKSQPSP VTVKPKPPAR SSSLPKVSSG YSSPTTSEAS IKDSPSQHSG RPSPGSDSQT
SLTEQPLFKL KYPSSPYSAH ISKSPRNMSP SSGHQSPAGS APSPALSYSS AGSARSSPAD
APDIDKLKMA AIDEKVQAVH NLKMFWQSTP QHSTGPMKIF RGTPGTMTSK RDVLSLLNLS
PRHNKKEEGV DKLELKELSL QQHGETPHKA PPNGHWRTET TTLSTLPLPA GPPAAAPTRP
LRLPSGNGYK FLSPGRFFPS SKC
//