ID A0A3Q2IBF8_HORSE Unreviewed; 1515 AA.
AC A0A3Q2IBF8;
DT 10-APR-2019, integrated into UniProtKB/TrEMBL.
DT 13-SEP-2023, sequence version 3.
DT 27-MAR-2024, entry version 22.
DE SubName: Full=Shroom family member 2 {ECO:0000313|Ensembl:ENSECAP00000045455.3};
GN Name=SHROOM2 {ECO:0000313|Ensembl:ENSECAP00000045455.3,
GN ECO:0000313|VGNC:VGNC:55534};
OS Equus caballus (Horse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Perissodactyla; Equidae; Equus.
OX NCBI_TaxID=9796 {ECO:0000313|Ensembl:ENSECAP00000045455.3, ECO:0000313|Proteomes:UP000002281};
RN [1] {ECO:0000313|Ensembl:ENSECAP00000045455.3, ECO:0000313|Proteomes:UP000002281}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Thoroughbred {ECO:0000313|Ensembl:ENSECAP00000045455.3,
RC ECO:0000313|Proteomes:UP000002281};
RX PubMed=19892987; DOI=10.1126/science.1178158;
RG Broad Institute Genome Sequencing Platform;
RG Broad Institute Whole Genome Assembly Team;
RA Wade C.M., Giulotto E., Sigurdsson S., Zoli M., Gnerre S., Imsland F.,
RA Lear T.L., Adelson D.L., Bailey E., Bellone R.R., Bloecker H., Distl O.,
RA Edgar R.C., Garber M., Leeb T., Mauceli E., MacLeod J.N., Penedo M.C.T.,
RA Raison J.M., Sharpe T., Vogel J., Andersson L., Antczak D.F., Biagi T.,
RA Binns M.M., Chowdhary B.P., Coleman S.J., Della Valle G., Fryc S.,
RA Guerin G., Hasegawa T., Hill E.W., Jurka J., Kiialainen A., Lindgren G.,
RA Liu J., Magnani E., Mickelson J.R., Murray J., Nergadze S.G., Onofrio R.,
RA Pedroni S., Piras M.F., Raudsepp T., Rocchi M., Roeed K.H., Ryder O.A.,
RA Searle S., Skow L., Swinburne J.E., Syvaenen A.C., Tozaki T., Valberg S.J.,
RA Vaudin M., White J.R., Zody M.C., Lander E.S., Lindblad-Toh K.;
RT "Genome sequence, comparative analysis, and population genetics of the
RT domestic horse.";
RL Science 326:865-867(2009).
RN [2] {ECO:0000313|Ensembl:ENSECAP00000045455.3}
RP IDENTIFICATION.
RC STRAIN=Thoroughbred {ECO:0000313|Ensembl:ENSECAP00000045455.3};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton
CC {ECO:0000256|ARBA:ARBA00004245}.
CC -!- SIMILARITY: Belongs to the shroom family.
CC {ECO:0000256|ARBA:ARBA00006469}.
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DR Ensembl; ENSECAT00000050189.3; ENSECAP00000045455.3; ENSECAG00000012150.4.
DR VGNC; VGNC:55534; SHROOM2.
DR GeneTree; ENSGT00940000155212; -.
DR Proteomes; UP000002281; Chromosome X.
DR Bgee; ENSECAG00000012150; Expressed in prefrontal cortex and 17 other cell types or tissues.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR GO; GO:0005874; C:microtubule; IEA:UniProtKB-KW.
DR GO; GO:0051015; F:actin filament binding; IEA:InterPro.
DR CDD; cd00992; PDZ_signaling; 1.
DR Gene3D; 2.30.42.10; -; 1.
DR Gene3D; 6.10.250.3120; -; 1.
DR InterPro; IPR014800; ASD1_dom.
DR InterPro; IPR014799; ASD2_dom.
DR InterPro; IPR001478; PDZ.
DR InterPro; IPR036034; PDZ_sf.
DR InterPro; IPR027685; Shroom_fam.
DR PANTHER; PTHR15012; APICAL PROTEIN/SHROOM-RELATED; 1.
DR PANTHER; PTHR15012:SF8; PROTEIN SHROOM2; 1.
DR Pfam; PF08688; ASD1; 1.
DR Pfam; PF08687; ASD2; 1.
DR SUPFAM; SSF50156; PDZ domain-like; 1.
DR PROSITE; PS51306; ASD1; 1.
DR PROSITE; PS51307; ASD2; 1.
DR PROSITE; PS50106; PDZ; 1.
PE 3: Inferred from homology;
KW Actin-binding {ECO:0000256|PROSITE-ProRule:PRU00637};
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Microtubule {ECO:0000256|ARBA:ARBA00022701};
KW Reference proteome {ECO:0000313|Proteomes:UP000002281}.
FT DOMAIN 1..59
FT /note="PDZ"
FT /evidence="ECO:0000259|PROSITE:PS50106"
FT DOMAIN 622..710
FT /note="ASD1"
FT /evidence="ECO:0000259|PROSITE:PS51306"
FT DOMAIN 1216..1510
FT /note="ASD2"
FT /evidence="ECO:0000259|PROSITE:PS51307"
FT REGION 148..185
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 200..371
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 413..439
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 452..618
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 634..727
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 741..773
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 785..1008
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1025..1103
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1121..1157
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1174..1199
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1263..1288
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 1304..1360
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 265..279
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 319..333
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 414..439
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 538..552
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 687..714
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 758..773
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 828..858
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 872..914
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 958..972
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1263..1284
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1515 AA; 166068 MW; 49B5674B05408393 CRC64;
MCTYERIEEG SKAAAVDKLL AGDEIVGIND IGLSGFRQEA ICLVKGSHKT LKLVVKRRNE
LSWRPHSWHA TKFSESHPET SASQFSTSVY PSWHGRHHAS SSSHDLSGTW EQTNLQRTSD
HFSSLGSVDS LDHPCQPYSS GCLSAAKSNS SIDRLGGPNQ RDSAYGSFST SSSTPDHTLP
KADASSTENI LYKVGLWEAS KPGSSRQGQA AGDPQGLEDR LGYFPPRVLC DSSKSPRPDD
SPEPKVASSG RSSFGPVWYV PDKKKAPSSP PPPPPPLRSD SFAATKSHEK AQGPPFSEVA
DTQHFPGLTW AQPRSDWRPE PGDQQRRLAH PTDGRRPGGS VWAPDAPCEW PASDHEAPSM
LQASLSSTDV RCPQPSYGYQ HLRQYSDESP FLYEGPSATT SPRKQLHVAL TGGFQDDSPT
QVRWPSAADQ KGDSSGQSRF CAPMRQCLQG GTRAAPLRGA GWHPATQPPG PKPRGGLSLL
EGSRGAPVRA SGDPEGRSPG VMERAGLKKA MTGLPWADGE SSKISPRQTP MLHLLAQEGT
RRPEDSQEGD PERPPPLDAQ GGKPTRRSDR FATTLRNEIQ MRRAKLQKSK STVTLAGTSE
GEEEAAGAGP EGSFPGTYKD HLQEAQARVL RATSFKRRDL DPSPADHYTG LPDHSTDPDP
VPRSWEVSLA KPPSSAGGMP HVPRIGGRRR FTVEQKLKSY SEPEKMHEVG LSGDHRPPQH
PGTSQETMGT FADRWKFFEE TSRPVQQRPG QRQALCGLSK EKLERPRTGG HVCEDAEPCF
QKRAHTTSFG ENADGHRTAG KLGKSEPPQR LGTFAEYQAS WREQRNALEA RSSGRYHSAD
DILDAGLDQH ERPQYIHERS RSSPSTDLYK QEASVEPRRQ AEDPGEHKEL SPTVRAEEGR
LTPRQADAQC REDSPGDQRN LSQVSELPHV PGAPEAPCEG RGRAGTLPRD YRYSEDKAPA
TPPPPLGPGP TAPAQALRPV SARRPGPQRP LRGPTGPAAG PRSRPRPLAS PVALEVCVAR
LSLSCSPSAS AEEPSSAQPA DGPKAAAEHD RQDVDERAAC PFPSQCRPLP PAAMDTSRSP
SPQFAPQKLT DKPPLLIQDE NSTRIERVID NNTTVKMVPI KIVHSESQPE KESRQGLARA
TELPELPSGL ERDQIKTLST SEQCYSRFCV YSRQGPEAEP QPPGALAPAA KDSQASPPGL
SYVKAKERTA EDLKSEELAR EIVGKDKSLA DILDPGVKIK TAMDLMEGIF PKDEHLLEEA
QQRRKLLPKI PSPRTAEEKK EEPSVPAAVS LATSSTYYST SAPKAELLIK MKDLREQQES
EESSGSDLDH DLSVKKQELI ESISRKLHVL REARESLLED IQANSVLGDE VEAIAKDVCK
PNEFDKFRMF IGDLDKVVNL LLSLSGRLAR VENALNNLDD STSPGDRQSL LEKQRVLIQQ
HEDAKELKEN LDRRERIVFD ILASYLSEES LADYEHFVKM KSALIIEQRE LEDKIHLGEE
QLKCLFDSLQ PERGK
//
