ID A0A3Q2ICS0_HORSE Unreviewed; 1709 AA.
AC A0A3Q2ICS0;
DT 10-APR-2019, integrated into UniProtKB/TrEMBL.
DT 13-SEP-2023, sequence version 2.
DT 27-MAR-2024, entry version 24.
DE SubName: Full=ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 2 {ECO:0000313|Ensembl:ENSECAP00000046006.2};
GN Name=ARAP2 {ECO:0000313|Ensembl:ENSECAP00000046006.2,
GN ECO:0000313|VGNC:VGNC:15440};
OS Equus caballus (Horse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Perissodactyla; Equidae; Equus.
OX NCBI_TaxID=9796 {ECO:0000313|Ensembl:ENSECAP00000046006.2, ECO:0000313|Proteomes:UP000002281};
RN [1] {ECO:0000313|Ensembl:ENSECAP00000046006.2, ECO:0000313|Proteomes:UP000002281}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Thoroughbred {ECO:0000313|Ensembl:ENSECAP00000046006.2,
RC ECO:0000313|Proteomes:UP000002281};
RX PubMed=19892987; DOI=10.1126/science.1178158;
RG Broad Institute Genome Sequencing Platform;
RG Broad Institute Whole Genome Assembly Team;
RA Wade C.M., Giulotto E., Sigurdsson S., Zoli M., Gnerre S., Imsland F.,
RA Lear T.L., Adelson D.L., Bailey E., Bellone R.R., Bloecker H., Distl O.,
RA Edgar R.C., Garber M., Leeb T., Mauceli E., MacLeod J.N., Penedo M.C.T.,
RA Raison J.M., Sharpe T., Vogel J., Andersson L., Antczak D.F., Biagi T.,
RA Binns M.M., Chowdhary B.P., Coleman S.J., Della Valle G., Fryc S.,
RA Guerin G., Hasegawa T., Hill E.W., Jurka J., Kiialainen A., Lindgren G.,
RA Liu J., Magnani E., Mickelson J.R., Murray J., Nergadze S.G., Onofrio R.,
RA Pedroni S., Piras M.F., Raudsepp T., Rocchi M., Roeed K.H., Ryder O.A.,
RA Searle S., Skow L., Swinburne J.E., Syvaenen A.C., Tozaki T., Valberg S.J.,
RA Vaudin M., White J.R., Zody M.C., Lander E.S., Lindblad-Toh K.;
RT "Genome sequence, comparative analysis, and population genetics of the
RT domestic horse.";
RL Science 326:865-867(2009).
RN [2] {ECO:0000313|Ensembl:ENSECAP00000046006.2}
RP IDENTIFICATION.
RC STRAIN=Thoroughbred {ECO:0000313|Ensembl:ENSECAP00000046006.2};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR Ensembl; ENSECAT00000037732.2; ENSECAP00000046006.2; ENSECAG00000018069.4.
DR VGNC; VGNC:15440; ARAP2.
DR GeneTree; ENSGT00940000160197; -.
DR Proteomes; UP000002281; Chromosome 3.
DR Bgee; ENSECAG00000018069; Expressed in brainstem and 21 other cell types or tissues.
DR ExpressionAtlas; A0A3Q2ICS0; baseline.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0005096; F:GTPase activator activity; IEA:UniProtKB-KW.
DR GO; GO:0005547; F:phosphatidylinositol-3,4,5-trisphosphate binding; IEA:Ensembl.
DR GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR CDD; cd08856; ArfGap_ARAP2; 1.
DR CDD; cd13253; PH1_ARAP; 1.
DR CDD; cd13254; PH2_ARAP; 1.
DR CDD; cd13256; PH3_ARAP; 1.
DR CDD; cd13257; PH4_ARAP; 1.
DR CDD; cd17227; RA_ARAP2; 1.
DR CDD; cd04385; RhoGAP_ARAP; 1.
DR CDD; cd09490; SAM_Arap1_2_3; 1.
DR Gene3D; 1.10.220.150; Arf GTPase activating protein; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 5.
DR Gene3D; 1.10.555.10; Rho GTPase activation protein; 1.
DR Gene3D; 1.10.150.50; Transcription Factor, Ets-1; 1.
DR InterPro; IPR037278; ARFGAP/RecO.
DR InterPro; IPR001164; ArfGAP_dom.
DR InterPro; IPR038508; ArfGAP_dom_sf.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR001849; PH_domain.
DR InterPro; IPR000159; RA_dom.
DR InterPro; IPR008936; Rho_GTPase_activation_prot.
DR InterPro; IPR037858; RhoGAP_ARAP.
DR InterPro; IPR000198; RhoGAP_dom.
DR InterPro; IPR001660; SAM.
DR InterPro; IPR013761; SAM/pointed_sf.
DR PANTHER; PTHR45899:SF1; ARF-GAP WITH RHO-GAP DOMAIN, ANK REPEAT AND PH DOMAIN-CONTAINING PROTEIN 2; 1.
DR PANTHER; PTHR45899; RHO GTPASE ACTIVATING PROTEIN AT 15B, ISOFORM C; 1.
DR Pfam; PF01412; ArfGap; 1.
DR Pfam; PF00169; PH; 4.
DR Pfam; PF00788; RA; 1.
DR Pfam; PF00620; RhoGAP; 1.
DR Pfam; PF07647; SAM_2; 1.
DR PRINTS; PR00405; REVINTRACTNG.
DR SMART; SM00105; ArfGap; 1.
DR SMART; SM00233; PH; 5.
DR SMART; SM00324; RhoGAP; 1.
DR SMART; SM00454; SAM; 1.
DR SUPFAM; SSF57863; ArfGap/RecO-like zinc finger; 1.
DR SUPFAM; SSF48350; GTPase activation domain, GAP; 1.
DR SUPFAM; SSF50729; PH domain-like; 5.
DR SUPFAM; SSF47769; SAM/Pointed domain; 1.
DR PROSITE; PS50115; ARFGAP; 1.
DR PROSITE; PS50003; PH_DOMAIN; 4.
DR PROSITE; PS50200; RA; 1.
DR PROSITE; PS50238; RHOGAP; 1.
DR PROSITE; PS50105; SAM_DOMAIN; 1.
PE 4: Predicted;
KW GTPase activation {ECO:0000256|ARBA:ARBA00022468};
KW Metal-binding {ECO:0000256|PROSITE-ProRule:PRU00288};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000002281};
KW Zinc {ECO:0000256|PROSITE-ProRule:PRU00288};
KW Zinc-finger {ECO:0000256|PROSITE-ProRule:PRU00288}.
FT DOMAIN 10..70
FT /note="SAM"
FT /evidence="ECO:0000259|PROSITE:PS50105"
FT DOMAIN 483..575
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT DOMAIN 588..680
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT DOMAIN 677..812
FT /note="Arf-GAP"
FT /evidence="ECO:0000259|PROSITE:PS50115"
FT DOMAIN 893..1004
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT DOMAIN 1117..1298
FT /note="Rho-GAP"
FT /evidence="ECO:0000259|PROSITE:PS50238"
FT DOMAIN 1327..1421
FT /note="Ras-associating"
FT /evidence="ECO:0000259|PROSITE:PS50200"
FT DOMAIN 1435..1538
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT REGION 428..463
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1544..1564
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1647..1675
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1690..1709
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 436..463
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1655..1670
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1694..1709
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1709 AA; 194269 MW; 027D8A62F51CDB3C CRC64;
MSSVSEVNVD IKDFLMSINL EQYLLHFREF GFNTVKDCAA INDSVLHKIG ISPTGHRRRI
LKQLQIILSK MQDIPIYANV HKTKNDETSK DCRAPSSDQN TCIELSNSGR VQTPSPTQLE
TVTRNLDQND VSVENSQSLK SDDKLSLPKH NFPIPEEEPH LHLGSFQDSL FGSENIKIGS
LITKTTADHA VVEEPVEKVD LISENVSQLT NADPECLSAF GYSLSEAAHS GSGTNGFSER
SPPSPCFQFQ GEMVVNDLYV PSSPVPAPVR SRSKLVSRPS RSFMLRHRPV PEIPGTIKGI
SGSYFRERRT VTTSTGKSVT QQNSNEENSS SIFPYGETFL FQKLENSKKK SIKNEFWTHE
ETLKGETTTG RNAFLVQSSI YDNRKEHLSE DKVEDIWIPR EDKTNFPIET ASESEYSTVE
ECFQSLRRKN SKASKSRTQK ALNSDPVNRH SYPSSSTSGN TDSSIISSTA ISPYACFYGS
SARKVKSGWL DKLCPQGKRM FQKRWVKFDG LSISYYNNEK EKYSKGIIPL SAVSTVRVQG
DNKFEVVTTQ RTFVFRVEKE EERNDWISIL LNALKSQPLS SQPQAVVAPE KCGYLELRGY
KAKIFTVLSG NSVWLCKNEQ DFKSGLGITV IPMNVANVKQ VDRTVKQSFE IITPYRSFSF
TAESEKEKQE WIEAVQQSIA ETLSDYEVAE KIWFNESNRS CADCKAPDPD WASINLCVVI
CKKCAGQHRS LGPKDSKVRS LKMDASIWSN ELIELFIVIG NKRANDFWAG NLKKDEELHM
DSPVEKRKNF ITQKYKEGRF RKTLLASLTK EELNKALCAA VVKSDVLETM ALLFSGADVM
CATGDPVHST PYLLAKKAGQ SLQMEFLHHN KFSDFPQHDV HSEGGLSQES CQSVFLCDFL
YQAPSAASKL SSEKKLLEET NKKWCVLEGG FLSYYENDKS TTPNGTININ EVICLAVHKE
DFYLNTGPIF TFEIYLPSER AFLFGAETPQ AQRKWTEAIA KHFVPFVAEN LTEADYDLIG
QLYYKDCHAL DQWRKGWFAM DKSSLRFCLQ MQEVQEDRMH LRRLQELTIS TMVQNGEKMD
VLLLVEKGRT LYIHGHTKLD FTVWHTAIEK AAGTDGNALQ DQQLSKNDVP IIVNSCIAFV
TQYGLGCKYI YQKNGDRLRV SELLENFKKD ARSFKLRAGK HQLEDVTGVL KSFLCDIDDA
LLTKELYPYW ISALDTQDDK ERIKKYGAFI RSLPGVNRAT LAAIIEHLYR VQKCSEINHM
DAHNLALVFS SCLFQTKGQT SEEVNVIEDL INNYVEIFEV KEDQVKQMDI ENSFITKWKD
TQVSQAGDLL IEVFVERKEP DCSIIIRISP VMEAEELTND ILAIKNIIPT KGDIWATFEV
IENEELERPL HYTENVLEQV LRWSSLAEPG SAYLVVKRFL TVDTIKHYNE RKALESIKDG
VLKIKEEPSK ILSGNKFQDR YFVLRDGYLF LYKDPKSSKY DRMFSLSSMK FYLGVKKKMK
PPTSWGLTAY SEKHHWHLCC DSLQSQMEWM ASIFIAQHEN DIRPPAGKER KRSITKNPKI
GGLPLIPIQH EKDAAQAQRN IENARAELER LRLSENRDGE SGDPSLKERA SIVAHCLEHK
DDKLRHRSRK HRSFNCLEDT EAAVLHGQQK GHKGLKTLRK TEDRNGKAPL DSDNKLPAKV
IEELSVVLQR SRTHPKELQG EQILQKEIK
//
