ID A0A3Q2IFR6_HORSE Unreviewed; 346 AA.
AC A0A3Q2IFR6;
DT 10-APR-2019, integrated into UniProtKB/TrEMBL.
DT 13-SEP-2023, sequence version 2.
DT 27-MAR-2024, entry version 18.
DE SubName: Full=Enoyl-CoA delta isomerase 2 {ECO:0000313|Ensembl:ENSECAP00000044542.2};
GN Name=ECI2 {ECO:0000313|Ensembl:ENSECAP00000044542.2,
GN ECO:0000313|VGNC:VGNC:17408};
OS Equus caballus (Horse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Perissodactyla; Equidae; Equus.
OX NCBI_TaxID=9796 {ECO:0000313|Ensembl:ENSECAP00000044542.2, ECO:0000313|Proteomes:UP000002281};
RN [1] {ECO:0000313|Ensembl:ENSECAP00000044542.2, ECO:0000313|Proteomes:UP000002281}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Thoroughbred {ECO:0000313|Ensembl:ENSECAP00000044542.2,
RC ECO:0000313|Proteomes:UP000002281};
RX PubMed=19892987; DOI=10.1126/science.1178158;
RG Broad Institute Genome Sequencing Platform;
RG Broad Institute Whole Genome Assembly Team;
RA Wade C.M., Giulotto E., Sigurdsson S., Zoli M., Gnerre S., Imsland F.,
RA Lear T.L., Adelson D.L., Bailey E., Bellone R.R., Bloecker H., Distl O.,
RA Edgar R.C., Garber M., Leeb T., Mauceli E., MacLeod J.N., Penedo M.C.T.,
RA Raison J.M., Sharpe T., Vogel J., Andersson L., Antczak D.F., Biagi T.,
RA Binns M.M., Chowdhary B.P., Coleman S.J., Della Valle G., Fryc S.,
RA Guerin G., Hasegawa T., Hill E.W., Jurka J., Kiialainen A., Lindgren G.,
RA Liu J., Magnani E., Mickelson J.R., Murray J., Nergadze S.G., Onofrio R.,
RA Pedroni S., Piras M.F., Raudsepp T., Rocchi M., Roeed K.H., Ryder O.A.,
RA Searle S., Skow L., Swinburne J.E., Syvaenen A.C., Tozaki T., Valberg S.J.,
RA Vaudin M., White J.R., Zody M.C., Lander E.S., Lindblad-Toh K.;
RT "Genome sequence, comparative analysis, and population genetics of the
RT domestic horse.";
RL Science 326:865-867(2009).
RN [2] {ECO:0000313|Ensembl:ENSECAP00000044542.2}
RP IDENTIFICATION.
RC STRAIN=Thoroughbred {ECO:0000313|Ensembl:ENSECAP00000044542.2};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR AlphaFoldDB; A0A3Q2IFR6; -.
DR Ensembl; ENSECAT00000055412.2; ENSECAP00000044542.2; ENSECAG00000000313.4.
DR VGNC; VGNC:17408; ECI2.
DR GeneTree; ENSGT00940000155105; -.
DR Proteomes; UP000002281; Chromosome 20.
DR Bgee; ENSECAG00000000313; Expressed in adult mammalian kidney and 23 other cell types or tissues.
DR GO; GO:0005777; C:peroxisome; IEA:UniProt.
DR GO; GO:0004165; F:delta(3)-delta(2)-enoyl-CoA isomerase activity; IEA:UniProt.
DR GO; GO:0000062; F:fatty-acyl-CoA binding; IEA:InterPro.
DR CDD; cd06558; crotonase-like; 1.
DR Gene3D; 1.20.80.10; -; 1.
DR Gene3D; 1.10.12.10; Lyase 2-enoyl-coa Hydratase, Chain A, domain 2; 1.
DR InterPro; IPR000582; Acyl-CoA-binding_protein.
DR InterPro; IPR035984; Acyl-CoA-binding_sf.
DR InterPro; IPR029045; ClpP/crotonase-like_dom_sf.
DR InterPro; IPR001753; Enoyl-CoA_hydra/iso.
DR InterPro; IPR014748; Enoyl-CoA_hydra_C.
DR InterPro; IPR014352; FERM/acyl-CoA-bd_prot_sf.
DR PANTHER; PTHR43684; -; 1.
DR PANTHER; PTHR43684:SF1; ENOYL-COA DELTA ISOMERASE 2; 1.
DR Pfam; PF00887; ACBP; 1.
DR Pfam; PF00378; ECH_1; 1.
DR SUPFAM; SSF47027; Acyl-CoA binding protein; 1.
DR SUPFAM; SSF52096; ClpP/crotonase; 1.
DR PROSITE; PS51228; ACB_2; 1.
PE 1: Evidence at protein level;
KW Proteomics identification {ECO:0007829|PeptideAtlas:A0A3Q2IFR6};
KW Reference proteome {ECO:0000313|Proteomes:UP000002281}.
FT DOMAIN 1..76
FT /note="ACB"
FT /evidence="ECO:0000259|PROSITE:PS51228"
SQ SEQUENCE 346 AA; 38202 MW; 94BC966D1BE1E787 CRC64;
MKERARGKLR PSSVPCDSVW EGKATEGPCN MPKPGIYDLI RKAKWEAWNT LGNLPKETAR
QNYVDLVSSL CSSSESSSQG KPGADREQLR YETLVVTSED GITKIMLNRP SKKNAVNLQM
YQEIVLALKA ASQDDSTITV LTGNGDYYSS GNDLTNFTNT SPGEIQEKAK NSLILVREFV
GCFIDFPKPL IAVVNGPAVG IAVTLLGLFD IVYASDRATF HTPFSRLGLH PEGCSSYTFP
KIMGPTKATE MLIFGKKLTA EEACAQGLVT EVFPDRTFQK EVWTRLKAYA KLPSNVLRIS
KQVIRNREKE KLHSVNVEEN SVLQGTVLSD EAVNAVMNFL SKRAKL
//
