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Database: UniProt
Entry: A0A3Q2IJK3_HORSE
LinkDB: A0A3Q2IJK3_HORSE
Original site: A0A3Q2IJK3_HORSE 
ID   A0A3Q2IJK3_HORSE        Unreviewed;      1122 AA.
AC   A0A3Q2IJK3;
DT   10-APR-2019, integrated into UniProtKB/TrEMBL.
DT   13-SEP-2023, sequence version 2.
DT   24-JAN-2024, entry version 20.
DE   SubName: Full=ALF transcription elongation factor 1 {ECO:0000313|Ensembl:ENSECAP00000045778.2};
GN   Name=AFF1 {ECO:0000313|Ensembl:ENSECAP00000045778.2,
GN   ECO:0000313|VGNC:VGNC:15144};
OS   Equus caballus (Horse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Perissodactyla; Equidae; Equus.
OX   NCBI_TaxID=9796 {ECO:0000313|Ensembl:ENSECAP00000045778.2, ECO:0000313|Proteomes:UP000002281};
RN   [1] {ECO:0000313|Ensembl:ENSECAP00000045778.2, ECO:0000313|Proteomes:UP000002281}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Thoroughbred {ECO:0000313|Ensembl:ENSECAP00000045778.2,
RC   ECO:0000313|Proteomes:UP000002281};
RX   PubMed=19892987; DOI=10.1126/science.1178158;
RG   Broad Institute Genome Sequencing Platform;
RG   Broad Institute Whole Genome Assembly Team;
RA   Wade C.M., Giulotto E., Sigurdsson S., Zoli M., Gnerre S., Imsland F.,
RA   Lear T.L., Adelson D.L., Bailey E., Bellone R.R., Bloecker H., Distl O.,
RA   Edgar R.C., Garber M., Leeb T., Mauceli E., MacLeod J.N., Penedo M.C.T.,
RA   Raison J.M., Sharpe T., Vogel J., Andersson L., Antczak D.F., Biagi T.,
RA   Binns M.M., Chowdhary B.P., Coleman S.J., Della Valle G., Fryc S.,
RA   Guerin G., Hasegawa T., Hill E.W., Jurka J., Kiialainen A., Lindgren G.,
RA   Liu J., Magnani E., Mickelson J.R., Murray J., Nergadze S.G., Onofrio R.,
RA   Pedroni S., Piras M.F., Raudsepp T., Rocchi M., Roeed K.H., Ryder O.A.,
RA   Searle S., Skow L., Swinburne J.E., Syvaenen A.C., Tozaki T., Valberg S.J.,
RA   Vaudin M., White J.R., Zody M.C., Lander E.S., Lindblad-Toh K.;
RT   "Genome sequence, comparative analysis, and population genetics of the
RT   domestic horse.";
RL   Science 326:865-867(2009).
RN   [2] {ECO:0000313|Ensembl:ENSECAP00000045778.2}
RP   IDENTIFICATION.
RC   STRAIN=Thoroughbred {ECO:0000313|Ensembl:ENSECAP00000045778.2};
RG   Ensembl;
RL   Submitted (JUL-2023) to UniProtKB.
CC   -!- SIMILARITY: Belongs to the AF4 family. {ECO:0000256|ARBA:ARBA00007354}.
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DR   AlphaFoldDB; A0A3Q2IJK3; -.
DR   Ensembl; ENSECAT00000041317.2; ENSECAP00000045778.2; ENSECAG00000003619.4.
DR   VGNC; VGNC:15144; AFF1.
DR   GeneTree; ENSGT00950000182974; -.
DR   Proteomes; UP000002281; Chromosome 3.
DR   Bgee; ENSECAG00000003619; Expressed in oviduct epithelium and 23 other cell types or tissues.
DR   ExpressionAtlas; A0A3Q2IJK3; baseline.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-KW.
DR   GO; GO:0010468; P:regulation of gene expression; IEA:InterPro.
DR   Gene3D; 6.10.250.2670; -; 1.
DR   InterPro; IPR007797; AF4/FMR2.
DR   InterPro; IPR043640; AF4/FMR2_CHD.
DR   InterPro; IPR043639; AF4_int.
DR   PANTHER; PTHR10528; AF4/FMR2 FAMILY MEMBER; 1.
DR   PANTHER; PTHR10528:SF6; AF4/FMR2 FAMILY MEMBER 1; 1.
DR   Pfam; PF05110; AF-4; 1.
DR   Pfam; PF18875; AF4_int; 1.
DR   Pfam; PF18876; AFF4_CHD; 1.
PE   3: Inferred from homology;
KW   Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW   Reference proteome {ECO:0000313|Proteomes:UP000002281}.
FT   DOMAIN          974..1122
FT                   /note="AF4/FMR2 C-terminal homology"
FT                   /evidence="ECO:0000259|Pfam:PF18876"
FT   REGION          26..60
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          79..168
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          207..330
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          382..982
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        79..93
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        109..132
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        221..249
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        283..298
FT                   /note="Pro residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        386..440
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        473..500
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        598..622
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        654..676
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        748..766
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        804..856
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        888..904
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        933..953
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1122 AA;  121368 MW;  D204DA815335B174 CRC64;
     MAFTERVNSS GNSLYNEDRN LLRIREKERR NQEAHQEKEA FPEKIPLFGE PYKTEKGDEL
     SSRIQNMLGN YEEVKELLST KSHPHRLDAS ENRLGKPRYP LFPEKGSSIP SHSFHTSVHH
     QPVNTPASGP LPVGNISHNP KMAQPRMEPM PSLHVKSYGA PDSQHLPQDR LGQEAYGSTH
     HKKGDRRADG DHCASMADLA PERELSPLLS SLPSPVPPLS PIHSSQQALP RTQGSTKVHS
     SNNNNKGYCP AKSPKDLAVK VRDKDPPPDG LVAVASLGVA PPQPPSQTFP PPPLPSKSIA
     MQQKPTAYVR PMDGQDQAPS ESPELKPLPE DYRQQTFEKT DLKVPAKAKL TKLKMPSQSV
     EQTYSNEAHC VEEILKEMTH SWPPPLTAIH TPSTAEPSKF PFPTKDSQHI SSATQNQKQY
     DTSSKTHTNS QQGTSMLEDD LQLSDSEDSD GEQTPEKPPS TSAPPSAPQS LPAAAASAHS
     SSAESESTSD SDSSSDSESE SSSSDSEENE PLEAPAPEPE PPTTNKWQLD NWLTKVSQPA
     APPEAPGGTE PPPRHLDGKG QGGEGGGLAG REHSDSKDPP PKSSSRAPRV PSEGPHAGKR
     SSQKSPAHQE PPQRQTVGTK QPKKAGKASG PAEPRAGLQV ESEPGAPPRG PAEQPAKDKP
     RVKTKGRPRA ADAGEPPEPA EPRPAVPAAG ERRKHRSGPA GPPKAPSGPE PPKDRVEARS
     PEHFALVPLA QSQGPPRGGG RTSGCRRAVV VQEERRKDKD KLPVPLRDTR LLSPLRDTPA
     PQSLVVKITL ELLSRVPPPP GKGSRPKKPE DRQAPPEKKL DAERRSSDNS SKLAKKRKGE
     AERDHDSKKV RLEKEIKSQS SSSSSHKESS KTKTPRPSSE PSKKEMLPPQ LVSSSSSSSQ
     KPAKPAQKRP RREAEPSGQD PPKSASSAKG SHKDSSVPKH RKVEGKGSES STEHKGSSGD
     IANPFPVPSL PNGNSKPGKP QMKFDKQQAD FYMKEAKKLK IKAETTTDKV GKAFKYAEAA
     LSLIECGIAM ESEGPAAKSA YSVYSETVDL INFVLSLKSF SDVTTPLPGK IFAVLCMRCQ
     SILNMAMFRC KKDTAIKYSR TLNEHFKISS KVAQAPSPCV AR
//
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