ID A0A3Q2IJK3_HORSE Unreviewed; 1122 AA.
AC A0A3Q2IJK3;
DT 10-APR-2019, integrated into UniProtKB/TrEMBL.
DT 13-SEP-2023, sequence version 2.
DT 24-JAN-2024, entry version 20.
DE SubName: Full=ALF transcription elongation factor 1 {ECO:0000313|Ensembl:ENSECAP00000045778.2};
GN Name=AFF1 {ECO:0000313|Ensembl:ENSECAP00000045778.2,
GN ECO:0000313|VGNC:VGNC:15144};
OS Equus caballus (Horse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Perissodactyla; Equidae; Equus.
OX NCBI_TaxID=9796 {ECO:0000313|Ensembl:ENSECAP00000045778.2, ECO:0000313|Proteomes:UP000002281};
RN [1] {ECO:0000313|Ensembl:ENSECAP00000045778.2, ECO:0000313|Proteomes:UP000002281}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Thoroughbred {ECO:0000313|Ensembl:ENSECAP00000045778.2,
RC ECO:0000313|Proteomes:UP000002281};
RX PubMed=19892987; DOI=10.1126/science.1178158;
RG Broad Institute Genome Sequencing Platform;
RG Broad Institute Whole Genome Assembly Team;
RA Wade C.M., Giulotto E., Sigurdsson S., Zoli M., Gnerre S., Imsland F.,
RA Lear T.L., Adelson D.L., Bailey E., Bellone R.R., Bloecker H., Distl O.,
RA Edgar R.C., Garber M., Leeb T., Mauceli E., MacLeod J.N., Penedo M.C.T.,
RA Raison J.M., Sharpe T., Vogel J., Andersson L., Antczak D.F., Biagi T.,
RA Binns M.M., Chowdhary B.P., Coleman S.J., Della Valle G., Fryc S.,
RA Guerin G., Hasegawa T., Hill E.W., Jurka J., Kiialainen A., Lindgren G.,
RA Liu J., Magnani E., Mickelson J.R., Murray J., Nergadze S.G., Onofrio R.,
RA Pedroni S., Piras M.F., Raudsepp T., Rocchi M., Roeed K.H., Ryder O.A.,
RA Searle S., Skow L., Swinburne J.E., Syvaenen A.C., Tozaki T., Valberg S.J.,
RA Vaudin M., White J.R., Zody M.C., Lander E.S., Lindblad-Toh K.;
RT "Genome sequence, comparative analysis, and population genetics of the
RT domestic horse.";
RL Science 326:865-867(2009).
RN [2] {ECO:0000313|Ensembl:ENSECAP00000045778.2}
RP IDENTIFICATION.
RC STRAIN=Thoroughbred {ECO:0000313|Ensembl:ENSECAP00000045778.2};
RG Ensembl;
RL Submitted (JUL-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the AF4 family. {ECO:0000256|ARBA:ARBA00007354}.
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DR AlphaFoldDB; A0A3Q2IJK3; -.
DR Ensembl; ENSECAT00000041317.2; ENSECAP00000045778.2; ENSECAG00000003619.4.
DR VGNC; VGNC:15144; AFF1.
DR GeneTree; ENSGT00950000182974; -.
DR Proteomes; UP000002281; Chromosome 3.
DR Bgee; ENSECAG00000003619; Expressed in oviduct epithelium and 23 other cell types or tissues.
DR ExpressionAtlas; A0A3Q2IJK3; baseline.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-KW.
DR GO; GO:0010468; P:regulation of gene expression; IEA:InterPro.
DR Gene3D; 6.10.250.2670; -; 1.
DR InterPro; IPR007797; AF4/FMR2.
DR InterPro; IPR043640; AF4/FMR2_CHD.
DR InterPro; IPR043639; AF4_int.
DR PANTHER; PTHR10528; AF4/FMR2 FAMILY MEMBER; 1.
DR PANTHER; PTHR10528:SF6; AF4/FMR2 FAMILY MEMBER 1; 1.
DR Pfam; PF05110; AF-4; 1.
DR Pfam; PF18875; AF4_int; 1.
DR Pfam; PF18876; AFF4_CHD; 1.
PE 3: Inferred from homology;
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000002281}.
FT DOMAIN 974..1122
FT /note="AF4/FMR2 C-terminal homology"
FT /evidence="ECO:0000259|Pfam:PF18876"
FT REGION 26..60
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 79..168
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 207..330
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 382..982
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 79..93
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 109..132
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 221..249
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 283..298
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 386..440
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 473..500
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 598..622
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 654..676
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 748..766
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 804..856
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 888..904
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 933..953
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1122 AA; 121368 MW; D204DA815335B174 CRC64;
MAFTERVNSS GNSLYNEDRN LLRIREKERR NQEAHQEKEA FPEKIPLFGE PYKTEKGDEL
SSRIQNMLGN YEEVKELLST KSHPHRLDAS ENRLGKPRYP LFPEKGSSIP SHSFHTSVHH
QPVNTPASGP LPVGNISHNP KMAQPRMEPM PSLHVKSYGA PDSQHLPQDR LGQEAYGSTH
HKKGDRRADG DHCASMADLA PERELSPLLS SLPSPVPPLS PIHSSQQALP RTQGSTKVHS
SNNNNKGYCP AKSPKDLAVK VRDKDPPPDG LVAVASLGVA PPQPPSQTFP PPPLPSKSIA
MQQKPTAYVR PMDGQDQAPS ESPELKPLPE DYRQQTFEKT DLKVPAKAKL TKLKMPSQSV
EQTYSNEAHC VEEILKEMTH SWPPPLTAIH TPSTAEPSKF PFPTKDSQHI SSATQNQKQY
DTSSKTHTNS QQGTSMLEDD LQLSDSEDSD GEQTPEKPPS TSAPPSAPQS LPAAAASAHS
SSAESESTSD SDSSSDSESE SSSSDSEENE PLEAPAPEPE PPTTNKWQLD NWLTKVSQPA
APPEAPGGTE PPPRHLDGKG QGGEGGGLAG REHSDSKDPP PKSSSRAPRV PSEGPHAGKR
SSQKSPAHQE PPQRQTVGTK QPKKAGKASG PAEPRAGLQV ESEPGAPPRG PAEQPAKDKP
RVKTKGRPRA ADAGEPPEPA EPRPAVPAAG ERRKHRSGPA GPPKAPSGPE PPKDRVEARS
PEHFALVPLA QSQGPPRGGG RTSGCRRAVV VQEERRKDKD KLPVPLRDTR LLSPLRDTPA
PQSLVVKITL ELLSRVPPPP GKGSRPKKPE DRQAPPEKKL DAERRSSDNS SKLAKKRKGE
AERDHDSKKV RLEKEIKSQS SSSSSHKESS KTKTPRPSSE PSKKEMLPPQ LVSSSSSSSQ
KPAKPAQKRP RREAEPSGQD PPKSASSAKG SHKDSSVPKH RKVEGKGSES STEHKGSSGD
IANPFPVPSL PNGNSKPGKP QMKFDKQQAD FYMKEAKKLK IKAETTTDKV GKAFKYAEAA
LSLIECGIAM ESEGPAAKSA YSVYSETVDL INFVLSLKSF SDVTTPLPGK IFAVLCMRCQ
SILNMAMFRC KKDTAIKYSR TLNEHFKISS KVAQAPSPCV AR
//